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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.
Nature. 2011.
PMID: 21760589
Free PMC article.
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM.
Zoncu R, et al.
Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.
Science. 2011.
PMID: 22053050
Free PMC article.
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Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.
Sheen JH, Zoncu R, Kim D, Sabatini DM.
Sheen JH, et al.
Cancer Cell. 2011 May 17;19(5):613-28. doi: 10.1016/j.ccr.2011.03.012.
Cancer Cell. 2011.
PMID: 21575862
Free PMC article.
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