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Targeting BET bromodomain proteins in solid tumors.
Sahai V, Redig AJ, Collier KA, Eckerdt FD, Munshi HG. Sahai V, et al. Oncotarget. 2016 Aug 16;7(33):53997-54009. doi: 10.18632/oncotarget.9804. Oncotarget. 2016. PMID: 27283767 Free PMC article. Review.
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
Principe DR, Xiong R, Li Y, Pham TND, Kamath SD, Dubrovskyi O, Ratia K, Huang F, Zhao J, Shen Z, Thummuri D, Daohong Z, Underwood PW, Trevino J, Munshi HG, Thatcher GRJ, Rana A. Principe DR, et al. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2116764119. doi: 10.1073/pnas.2116764119. Proc Natl Acad Sci U S A. 2022. PMID: 35064087 Free PMC article.
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