R01 CA226852/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	1
2020	6
2021	7
2022	4
2023	3
2024	1

1

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair.

Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW. Demin AA, et al. Mol Cell. 2021 Jul 15;81(14):3018-3030.e5. doi: 10.1016/j.molcel.2021.05.009. Epub 2021 Jun 7. Mol Cell. 2021. PMID: 34102106 Free PMC article.

2

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.

Shao Z, Lee BJ, Zhang H, Lin X, Li C, Jiang W, Chirathivat N, Gershik S, Shen MM, Baer R, Zha S. Shao Z, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2301972120. doi: 10.1073/pnas.2301972120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487079 Free PMC article.

3

The recent advances in non-homologous end-joining through the lens of lymphocyte development.

Wang XS, Lee BJ, Zha S. Wang XS, et al. DNA Repair (Amst). 2020 Oct;94:102874. doi: 10.1016/j.dnarep.2020.102874. Epub 2020 Jun 25. DNA Repair (Amst). 2020. PMID: 32623318 Free PMC article. Review.

4

Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.

Lin X, Gupta D, Vaitsiankova A, Bhandari SK, Leung KSK, Menolfi D, Lee BJ, Russell HR, Gershik S, Huang X, Gu W, McKinnon PJ, Dantzer F, Rothenberg E, Tomkinson AE, Zha S. Lin X, et al. Mol Cell. 2024 Oct 17;84(20):3916-3931.e7. doi: 10.1016/j.molcel.2024.09.020. Epub 2024 Oct 8. Mol Cell. 2024. PMID: 39383878

5

Targeting BRCA-mutated tumors in mitosis.

Menolfi D, Zha S. Menolfi D, et al. Nat Cancer. 2021 Dec;2(12):1296-1297. doi: 10.1038/s43018-021-00293-7. Nat Cancer. 2021. PMID: 35121918 No abstract available.

6

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.

Menolfi D, Lee BJ, Zhang H, Jiang W, Bowen NE, Wang Y, Zhao J, Holmes A, Gershik S, Rabadan R, Kim B, Zha S. Menolfi D, et al. Nat Commun. 2023 Jun 19;14(1):3618. doi: 10.1038/s41467-023-39332-5. Nat Commun. 2023. PMID: 37336885 Free PMC article.

7

Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging.

Zhang H, Lin X, Zha S. Zhang H, et al. Biochem Soc Trans. 2022 Aug 31;50(4):1169-1177. doi: 10.1042/BST20220366. Biochem Soc Trans. 2022. PMID: 35959996

8

PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.

Lin X, Jiang W, Rudolph J, Lee BJ, Luger K, Zha S. Lin X, et al. Nucleic Acids Res. 2022 Apr 22;50(7):3958-3973. doi: 10.1093/nar/gkac188. Nucleic Acids Res. 2022. PMID: 35349716 Free PMC article.

9

The plié by DNA-PK: dancing on DNA.

Zha S, Shao Z, Zhu Y. Zha S, et al. Mol Cell. 2021 Feb 18;81(4):644-646. doi: 10.1016/j.molcel.2021.01.025. Mol Cell. 2021. PMID: 33606972 Free article.

10

Targeting Scaffolding Functions of Enzymes Using PROTAC Approaches.

Kim C, Wang XD, Liu Z, Zha S, Yu Y. Kim C, et al. Biochemistry. 2023 Feb 7;62(3):561-563. doi: 10.1021/acs.biochem.2c00366. Epub 2022 Jul 14. Biochemistry. 2023. PMID: 35834793 Free PMC article. No abstract available.

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