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Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1.
Coleman DJL, Keane P, Chin PS, Ames L, Kellaway S, Blair H, Khan N, Griffin J, Holmes E, Maytum A, Potluri S, Strate L, Koscielniak K, Raghavan M, Bushweller J, Heidenreich O, Rabbitts T, Cockerill PN, Bonifer C. Coleman DJL, et al. iScience. 2024 Mar 26;27(4):109576. doi: 10.1016/j.isci.2024.109576. eCollection 2024 Apr 19. iScience. 2024. PMID: 38638836 Free PMC article.
Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia.
Sugita M, Galetto R, Zong H, Ewing-Crystal N, Trujillo-Alonso V, Mencia-Trinchant N, Yip W, Filipe S, Lebuhotel C, Gouble A, Hassane DC, Smith J, Roboz GJ, Guzman ML. Sugita M, et al. Nat Commun. 2022 Apr 28;13(1):2227. doi: 10.1038/s41467-022-29668-9. Nat Commun. 2022. PMID: 35484102 Free PMC article.
TNF-α signaling regulates RUNX1 function in endothelial cells.
Whitmore HAB, Amarnani D, O'Hare M, Delgado-Tirado S, Gonzalez-Buendia L, An M, Pedron J, Bushweller JH, Arboleda-Velasquez JF, Kim LA. Whitmore HAB, et al. FASEB J. 2021 Feb;35(2):e21155. doi: 10.1096/fj.202001668R. Epub 2020 Nov 2. FASEB J. 2021. PMID: 33135824 Free PMC article.
Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL.
Balandrán JC, Dávila-Velderrain J, Sandoval-Cabrera A, Zamora-Herrera G, Terán-Cerqueda V, García-Stivalet LA, Limón-Flores JA, Armenta-Castro E, Rodríguez-Martínez A, Leon-Chavez BA, Vallejo-Ruiz V, Hassane DC, Pérez-Tapia SM, Ortiz-Navarrete V, Guzman ML, Pelayo R. Balandrán JC, et al. Front Immunol. 2021 Oct 19;12:746492. doi: 10.3389/fimmu.2021.746492. eCollection 2021. Front Immunol. 2021. PMID: 34737747 Free PMC article.
20 results