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There are gremlins in prostate cancer.
Sena LA, Brennen WN, Isaacs JT. Sena LA, et al. Nat Cancer. 2022 May;3(5):530-531. doi: 10.1038/s43018-022-00381-2. Nat Cancer. 2022. PMID: 35624340 Free PMC article.
Defining the challenges and opportunities for using patient-derived models in prostate cancer research.
Brennen WN, Le Magnen C, Karkampouna S, Anselmino N, Bock N, Choo N, Clark AK, Coleman IM, Dolgos R, Ferguson AM, Goode DL, Krutihof-de Julio M, Navone NM, Nelson PS, O'Neill E, Porter LH, Ranasinghe W, Sunada T, Williams ED, Butler LM, Corey E, van Weerden WM, Taylor RA, Risbridger GP, Lawrence MG. Brennen WN, et al. Prostate. 2024 May;84(7):623-635. doi: 10.1002/pros.24682. Epub 2024 Mar 7. Prostate. 2024. PMID: 38450798 Free article. Review.
Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer.
Brennen WN, Zhu Y, Coleman IM, Dalrymple SL, Antony L, Patel RA, Hanratty B, Chikarmane R, Meeker AK, Zheng SL, Hooper JE, Luo J, De Marzo AM, Corey E, Xu J, Yegnasubramanian S, Haffner MC, Nelson PS, Nelson WG, Isaacs WB, Isaacs JT. Brennen WN, et al. JCI Insight. 2021 Apr 22;6(8):e146827. doi: 10.1172/jci.insight.146827. JCI Insight. 2021. PMID: 33724955 Free PMC article.
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models.
Jasmine S, Mandl A, Krueger TEG, Dalrymple SL, Antony L, Dias J, Celatka CA, Tapper AE, Kleppe M, Kanayama M, Jing Y, Speranzini V, Wang YZ, Luo J, Trock BJ, Denmeade SR, Carducci MA, Mattevi A, Rienhoff HY Jr, Isaacs JT, Brennen WN. Jasmine S, et al. Prostate. 2024 Jul;84(10):909-921. doi: 10.1002/pros.24707. Epub 2024 Apr 15. Prostate. 2024. PMID: 38619005 Free PMC article.