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Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization.
Cell Signal. 2010 Apr;22(4):684-96. doi: 10.1016/j.cellsig.2009.12.003. Epub 2010 Jan 5.
Cell Signal. 2010.
PMID: 20043990
Free PMC article.
Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins.
Chu J, Zheng H, Loh HH, Law PY.
Chu J, et al.
Cell Signal. 2008 Sep;20(9):1616-24. doi: 10.1016/j.cellsig.2008.05.004. Epub 2008 May 18.
Cell Signal. 2008.
PMID: 18558479
Free PMC article.
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Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation.
Zheng H, Loh HH, Law PY.
Zheng H, et al.
Mol Pharmacol. 2008 Jan;73(1):178-90. doi: 10.1124/mol.107.039842. Epub 2007 Oct 18.
Mol Pharmacol. 2008.
PMID: 17947509
Free PMC article.
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