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Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.
J Mol Biol. 2009 Jul 10;390(2):196-207. doi: 10.1016/j.jmb.2009.04.073. Epub 2009 May 6.
J Mol Biol. 2009.
PMID: 19426743
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.
Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MR.
Rock FL, et al.
Science. 2007 Jun 22;316(5832):1759-61. doi: 10.1126/science.1142189.
Science. 2007.
PMID: 17588934
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