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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways.
Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Basile G, et al. Cell Metab. 2023 Jul 11;35(7):1242-1260.e9. doi: 10.1016/j.cmet.2023.05.007. Epub 2023 Jun 19. Cell Metab. 2023. PMID: 37339634 Free PMC article.
Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor.
Liapakis G, Karageorgos V, Andreadelis I, Holz GG, Dermitzaki E, Kordopati GG, Stylos EΚ, Spyridaki K, Poulaki S, Ntountaniotis D, Sakellaris S, Vanioti M, Kostagianni A, Marousis KD, Leonis G, Kokotos G, Venihaki M, Spyroulias GA, Tselios T, Margioris A, Tzakos AG, Mavromoustakos T. Liapakis G, et al. Amino Acids. 2020 Sep;52(9):1337-1351. doi: 10.1007/s00726-020-02895-4. Epub 2020 Sep 29. Amino Acids. 2020. PMID: 32996057 Free PMC article.
Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists.
Elgiushy HR, Abou-Taleb NA, Holz GG, Chepurny OG, Pirmettis I, Kakabakos S, Karageorgos V, Liapakis G, Albohy A, Abouzid KAM, Hammad SF. Elgiushy HR, et al. Bioorg Chem. 2021 Sep;114:105079. doi: 10.1016/j.bioorg.2021.105079. Epub 2021 Jun 10. Bioorg Chem. 2021. PMID: 34174633 Free PMC article.
Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis.
Borner T, Workinger JL, Tinsley IC, Fortin SM, Stein LM, Chepurny OG, Holz GG, Wierzba AJ, Gryko D, Nexø E, Shaulson ED, Bamezai A, Da Silva VAR, De Jonghe BC, Hayes MR, Doyle RP. Borner T, et al. Cell Rep. 2020 Jun 16;31(11):107768. doi: 10.1016/j.celrep.2020.107768. Cell Rep. 2020. PMID: 32553160 Free PMC article.
22 results