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Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure.
Speakman JR, de Jong JMA, Sinha S, Westerterp KR, Yamada Y, Sagayama H, Ainslie PN, Anderson LJ, Arab L, Bedu-Addo K, Blanc S, Bonomi AG, Bovet P, Brage S, Buchowski MS, Butte NF, Camps SGJA, Cooper JA, Cooper R, Das SK, Davies PSW, Dugas LR, Ekelund U, Entringer S, Forrester T, Fudge BW, Gillingham M, Ghosh S, Goris AH, Gurven M, Halsey LG, Hambly C, Haisma HH, Hoffman D, Hu S, Joosen AM, Kaplan JL, Katzmarzyk P, Kraus WE, Kushner RF, Leonard WR, Löf M, Martin CK, Matsiko E, Medin AC, Meijer EP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Plange-Rhule J, Plasqui G, Prentice RL, Racette SB, Raichlen DA, Ravussin E, Redman LM, Roberts SB, Rudolph MC, Sardinha LB, Schuit AJ, Silva AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wood BM, Yanovski JA, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Kurpad A, Luke AH, Pontzer H, Rodeheffer MS, Rood J, Schoeller DA, Wong WW. Speakman JR, et al. Nat Metab. 2023 Apr;5(4):579-588. doi: 10.1038/s42255-023-00782-2. Epub 2023 Apr 26. Nat Metab. 2023. PMID: 37100994 Free PMC article.
A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure.
Benevento M, Alpár A, Gundacker A, Afjehi L, Balueva K, Hevesi Z, Hanics J, Rehman S, Pollak DD, Lubec G, Wulff P, Prevot V, Horvath TL, Harkany T. Benevento M, et al. Nature. 2024 Apr;628(8009):826-834. doi: 10.1038/s41586-024-07232-3. Epub 2024 Mar 27. Nature. 2024. PMID: 38538787 Free PMC article.
CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.
Hammerschmidt P, Steculorum SM, Bandet CL, Del Río-Martín A, Steuernagel L, Kohlhaas V, Feldmann M, Varela L, Majcher A, Quatorze Correia M, Klar RFU, Bauder CA, Kaya E, Porniece M, Biglari N, Sieben A, Horvath TL, Hornemann T, Brodesser S, Brüning JC. Hammerschmidt P, et al. Nat Commun. 2023 Nov 29;14(1):7824. doi: 10.1038/s41467-023-42595-7. Nat Commun. 2023. PMID: 38016943 Free PMC article.
TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.
Xie D, Stutz B, Li F, Chen F, Lv H, Sestan-Pesa M, Catarino J, Gu J, Zhao H, Stoddard CE, Carmichael GG, Shanabrough M, Taylor HS, Liu ZW, Gao XB, Horvath TL, Huang Y. Xie D, et al. J Clin Invest. 2022 Oct 3;132(19):e162365. doi: 10.1172/JCI162365. J Clin Invest. 2022. PMID: 36189793 Free PMC article.
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids.
Endle H, Horta G, Stutz B, Muthuraman M, Tegeder I, Schreiber Y, Snodgrass IF, Gurke R, Liu ZW, Sestan-Pesa M, Radyushkin K, Streu N, Fan W, Baumgart J, Li Y, Kloss F, Groppa S, Opel N, Dannlowski U, Grabe HJ, Zipp F, Rácz B, Horvath TL, Nitsch R, Vogt J. Endle H, et al. Nat Metab. 2022 Jun;4(6):683-692. doi: 10.1038/s42255-022-00589-7. Epub 2022 Jun 27. Nat Metab. 2022. PMID: 35760867 Free PMC article.
14 results