R01 GM031001-27/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

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Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.

Mast N, White MA, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. Mast N, et al. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9546-51. doi: 10.1073/pnas.0803717105. Epub 2008 Jul 9. Proc Natl Acad Sci U S A. 2008. PMID: 18621681 Free PMC article.

Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.

Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF. Schoch GA, et al. J Biol Chem. 2008 Jun 20;283(25):17227-37. doi: 10.1074/jbc.M802180200. Epub 2008 Apr 15. J Biol Chem. 2008. PMID: 18413310 Free PMC article.

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1.

White MA, Mast N, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. White MA, et al. Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):487-95. doi: 10.1107/S0907444908004046. Epub 2008 Apr 19. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18453684 Free PMC article.

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

Kartha JS, Skordos KW, Sun H, Hall C, Easterwood LM, Reilly CA, Johnson EF, Yost GS. Kartha JS, et al. Biochemistry. 2008 Sep 16;47(37):9756-70. doi: 10.1021/bi8005658. Epub 2008 Aug 22. Biochemistry. 2008. PMID: 18717595 Free PMC article.

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