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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.
Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, Chong LW, Evans RM, Thompson BM, McDonald JG, Hosseini M, Witztum JL, Germain RN, Glass CK. Seidman JS, et al. Immunity. 2020 Jun 16;52(6):1057-1074.e7. doi: 10.1016/j.immuni.2020.04.001. Epub 2020 May 1. Immunity. 2020. PMID: 32362324 Free PMC article.
Circular ecDNA promotes accessible chromatin and high oncogene expression.
Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. Wu S, et al. Nature. 2019 Nov;575(7784):699-703. doi: 10.1038/s41586-019-1763-5. Epub 2019 Nov 20. Nature. 2019. PMID: 31748743 Free PMC article.
Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis.
Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. Sun X, et al. Cell Metab. 2020 Jan 7;31(1):189-206.e8. doi: 10.1016/j.cmet.2019.10.014. Epub 2019 Nov 21. Cell Metab. 2020. PMID: 31761566 Free PMC article.
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.
Sakai M, Troutman TD, Seidman JS, Ouyang Z, Spann NJ, Abe Y, Ego KM, Bruni CM, Deng Z, Schlachetzki JCM, Nott A, Bennett H, Chang J, Vu BT, Pasillas MP, Link VM, Texari L, Heinz S, Thompson BM, McDonald JG, Geissmann F, Glass CK. Sakai M, et al. Immunity. 2019 Oct 15;51(4):655-670.e8. doi: 10.1016/j.immuni.2019.09.002. Epub 2019 Oct 3. Immunity. 2019. PMID: 31587991 Free PMC article.
Daedal Facets of Splice Modulator Optimization.
Chan WC, León B, Krug KA, Patel A, La Clair JJ, Burkart MD. Chan WC, et al. ACS Med Chem Lett. 2018 Oct 29;9(11):1070-1072. doi: 10.1021/acsmedchemlett.8b00456. eCollection 2018 Nov 8. ACS Med Chem Lett. 2018. PMID: 30429946 Free PMC article.
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.
Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. Cohen Katsenelson K, et al. Elife. 2019 Aug 13;8:e48609. doi: 10.7554/eLife.48609. Elife. 2019. PMID: 31408005 Free PMC article.
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