Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells

Fertil Steril. 2011 Jun 30;95(8):2464-6. doi: 10.1016/j.fertnstert.2011.03.026. Epub 2011 Apr 9.

Abstract

Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Analysis of Variance
  • Autocrine Communication
  • Cell Adhesion
  • Cell Line
  • Cell Movement*
  • Cell Proliferation*
  • Coculture Techniques
  • Endometriosis / metabolism*
  • Endometriosis / pathology
  • Endometrium / metabolism*
  • Endometrium / pathology
  • Epithelial Cells / metabolism*
  • Epithelial Cells / pathology
  • Female
  • Humans
  • Macrophage Colony-Stimulating Factor / genetics
  • Macrophage Colony-Stimulating Factor / metabolism*
  • Peritoneum / metabolism
  • Peritoneum / pathology
  • RNA Interference
  • Time Factors

Substances

  • Macrophage Colony-Stimulating Factor