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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA. Palomero T, et al. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6. doi: 10.1073/pnas.0606108103. Epub 2006 Nov 17. Proc Natl Acad Sci U S A. 2006. PMID: 17114293 Free PMC article.
Control of developmental regulators by Polycomb in human embryonic stem cells.
Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA. Lee TI, et al. Cell. 2006 Apr 21;125(2):301-13. doi: 10.1016/j.cell.2006.02.043. Cell. 2006. PMID: 16630818 Free PMC article.
Core transcriptional regulatory circuitry in human hepatocytes.
Odom DT, Dowell RD, Jacobsen ES, Nekludova L, Rolfe PA, Danford TW, Gifford DK, Fraenkel E, Bell GI, Young RA. Odom DT, et al. Mol Syst Biol. 2006;2:2006.0017. doi: 10.1038/msb4100059. Epub 2006 May 2. Mol Syst Biol. 2006. PMID: 16738562 Free PMC article.