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A blood-based marker of mitochondrial DNA damage in Parkinson's disease.
Qi R, Sammler E, Gonzalez-Hunt CP, Barraza I, Pena N, Rouanet JP, Naaldijk Y, Goodson S, Fuzzati M, Blandini F, Erickson KI, Weinstein AM, Lutz MW, Kwok JB, Halliday GM, Dzamko N, Padmanabhan S, Alcalay RN, Waters C, Hogarth P, Simuni T, Smith D, Marras C, Tonelli F, Alessi DR, West AB, Shiva S, Hilfiker S, Sanders LH. Qi R, et al. Sci Transl Med. 2023 Aug 30;15(711):eabo1557. doi: 10.1126/scitranslmed.abo1557. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647388 Free PMC article.
Peripheral Klotho and Parkinson's Disease.
Kakar RS, Pastor JV, Moe OW, Ambrosio F, Castaldi D, Sanders LH. Kakar RS, et al. Mov Disord. 2021 May;36(5):1274-1276. doi: 10.1002/mds.28530. Epub 2021 Feb 25. Mov Disord. 2021. PMID: 33629770 Free PMC article. No abstract available.
Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson's disease.
Sastre D, Zafar F, Torres CAM, Piper D, Kirik D, Sanders LH, Qi S, Schüle B. Sastre D, et al. bioRxiv [Preprint]. 2023 Jan 24:2023.01.24.525105. doi: 10.1101/2023.01.24.525105. bioRxiv. 2023. Update in: Sci Rep. 2023 Oct 18;13(1):17796. doi: 10.1038/s41598-023-45078-3 PMID: 36747875 Free PMC article. Updated. Preprint.