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Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.
Zaman K, Ryu H, Hall D, O'Donovan K, Lin KI, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Zaman K, et al. J Neurosci. 1999 Nov 15;19(22):9821-30. doi: 10.1523/JNEUROSCI.19-22-09821.1999. J Neurosci. 1999. PMID: 10559391 Free PMC article.
In vitro model of oxidative stress in cortical neurons.
Ratan RR, Ryu H, Lee J, Mwidau A, Neve RL. Ratan RR, et al. Methods Enzymol. 2002;352:183-90. doi: 10.1016/s0076-6879(02)52018-8. Methods Enzymol. 2002. PMID: 12125346 No abstract available.