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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.
PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775. eCollection 2014 Apr.
PLoS Negl Trop Dis. 2014.
PMID: 24743796
Free PMC article.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Koh CY, Siddaramaiah LK, Ranade RM, Nguyen J, Jian T, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG.
Koh CY, et al.
Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1684-98. doi: 10.1107/S1399004715007683. Epub 2015 Jul 31.
Acta Crystallogr D Biol Crystallogr. 2015.
PMID: 26249349
Free PMC article.
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