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Page 1
Platelet Extracellular Vesicles: Beyond the Blood.
Puhm F, Boilard E, Machlus KR. Puhm F, et al. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):87-96. doi: 10.1161/ATVBAHA.120.314644. Epub 2020 Oct 8. Arterioscler Thromb Vasc Biol. 2021. PMID: 33028092 Free PMC article. Review.
Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.
Khan AO, Rodriguez-Romera A, Reyat JS, Olijnik AA, Colombo M, Wang G, Wen WX, Sousos N, Murphy LC, Grygielska B, Perrella G, Mahony CB, Ling RE, Elliott NE, Karali CS, Stone AP, Kemble S, Cutler EA, Fielding AK, Croft AP, Bassett D, Poologasundarampillai G, Roy A, Gooding S, Rayes J, Machlus KR, Psaila B. Khan AO, et al. Cancer Discov. 2023 Feb 6;13(2):364-385. doi: 10.1158/2159-8290.CD-22-0199. Cancer Discov. 2023. PMID: 36351055 Free PMC article.
The bone marrow is the primary site of thrombopoiesis.
Asquith NL, Carminita E, Camacho V, Rodriguez-Romera A, Stegner D, Freire D, Becker IC, Machlus KR, Khan AO, Italiano JE. Asquith NL, et al. Blood. 2024 Jan 18;143(3):272-278. doi: 10.1182/blood.2023020895. Blood. 2024. PMID: 37879046
Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36.
Barrachina MN, Pernes G, Becker IC, Allaeys I, Hirsch TI, Groeneveld DJ, Khan AO, Freire D, Guo K, Carminita E, Morgan PK, Collins TJC, Mellett NA, Wei Z, Almazni I, Italiano JE, Luyendyk J, Meikle PJ, Puder M, Morgan NV, Boilard E, Murphy AJ, Machlus KR. Barrachina MN, et al. Nat Cardiovasc Res. 2023 Aug;2(8):746-763. doi: 10.1038/s44161-023-00305-y. Epub 2023 Jul 17. Nat Cardiovasc Res. 2023. PMID: 39195958
The origin of the megakaryocyte.
Machlus KR, Boilard E. Machlus KR, et al. Nat Cardiovasc Res. 2022 Jul;1(7):593-594. doi: 10.1038/s44161-022-00099-5. Nat Cardiovasc Res. 2022. PMID: 39196244 No abstract available.
Cell cycle-dependent centrosome clustering precedes proplatelet formation.
Becker IC, Wilkie AR, Nikols E, Carminita E, Roweth HG, Tilburg J, Sciaudone AR, Noetzli LJ, Fatima F, Couldwell G, Ray A, Mogilner A, Machlus KR, Italiano JE Jr. Becker IC, et al. Sci Adv. 2024 Jun 21;10(25):eadl6153. doi: 10.1126/sciadv.adl6153. Epub 2024 Jun 19. Sci Adv. 2024. PMID: 38896608 Free PMC article.
Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36.
Barrachina MN, Pernes G, Becker IC, Allaeys I, Hirsch TI, Groeneveld DJ, Khan AO, Freire D, Guo K, Carminita E, Morgan PK, Collins TJ, Mellett NA, Wei Z, Almazni I, Italiano JE, Luyendyk J, Meikle PJ, Puder M, Morgan NV, Boilard E, Murphy AJ, Machlus KR. Barrachina MN, et al. bioRxiv [Preprint]. 2023 Feb 12:2023.02.12.527706. doi: 10.1101/2023.02.12.527706. bioRxiv. 2023. PMID: 36798332 Free PMC article. Updated. Preprint.
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