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Targeting RIPK1 for the treatment of human diseases.
Degterev A, Ofengeim D, Yuan J. Degterev A, et al. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9714-9722. doi: 10.1073/pnas.1901179116. Epub 2019 May 2. Proc Natl Acad Sci U S A. 2019. PMID: 31048504 Free PMC article. Review.
Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice.
Lule S, Wu L, Sarro-Schwartz A, Edmiston WJ 3rd, Izzy S, Songtachalert T, Ahn SH, Fernandes ND, Jin G, Chung JY, Balachandran S, Lo EH, Kaplan D, Degterev A, Whalen MJ. Lule S, et al. J Cereb Blood Flow Metab. 2021 Jul;41(7):1623-1633. doi: 10.1177/0271678X20973609. Epub 2020 Nov 19. J Cereb Blood Flow Metab. 2021. PMID: 33210566 Free PMC article.
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.
Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD. Suebsuwong C, et al. Eur J Med Chem. 2020 Aug 15;200:112417. doi: 10.1016/j.ejmech.2020.112417. Epub 2020 May 15. Eur J Med Chem. 2020. PMID: 32505849 Free PMC article.