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Page 1
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. Liu S, et al. Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3. Cell. 2019. PMID: 30612740 Free PMC article.
Exploring the targeting spectrum of rocaglates among eIF4A homologs.
Naineni SK, Cencic R, Robert F, Brown LE, Haque M, Scott-Talib J, Sénéchal P, Schmeing TM, Porco JA Jr, Pelletier J. Naineni SK, et al. RNA. 2023 Jun;29(6):826-835. doi: 10.1261/rna.079318.122. Epub 2023 Mar 7. RNA. 2023. PMID: 36882295 Free PMC article.
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation.
Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA Jr, Pelletier J. Itoua Maïga R, et al. Sci Rep. 2019 Feb 4;9(1):1265. doi: 10.1038/s41598-018-37666-5. Sci Rep. 2019. PMID: 30718665 Free PMC article.
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.
Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, Lecomte N, Mayer S, Stok R, Bishara H, Hamodi R, Levy-Lahad E, Golan T, Porco JA Jr, Iacobuzio-Donahue CA, Schultz N, Tuveson DA, Lyden D, Kelsen D, Scherz-Shouval R. Shaashua L, et al. Nat Commun. 2022 Oct 31;13(1):6513. doi: 10.1038/s41467-022-34081-3. Nat Commun. 2022. PMID: 36316305 Free PMC article.
The MYCN 5' UTR as a therapeutic target in neuroblastoma.
Volegova MP, Brown LE, Banerjee U, Dries R, Sharma B, Kennedy A, Porco JA Jr, George RE. Volegova MP, et al. Cell Rep. 2024 May 28;43(5):114134. doi: 10.1016/j.celrep.2024.114134. Epub 2024 Apr 23. Cell Rep. 2024. PMID: 38662542 Free PMC article.
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Nishida Y, Zhao R, Heese LE, Akiyama H, Patel S, Jaeger AM, Jacamo RO, Kojima K, Ma MCJ, Ruvolo VR, Chachad D, Devine W, Lindquist S, Davis RE, Porco JA Jr, Whitesell L, Andreeff M, Ishizawa J. Nishida Y, et al. Leukemia. 2021 Sep;35(9):2469-2481. doi: 10.1038/s41375-021-01308-z. Epub 2021 Jun 14. Leukemia. 2021. PMID: 34127794 Free PMC article. Review.
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