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A membrane-associated MHC-I inhibitory axis for cancer immune evasion.
Chen X, Lu Q, Zhou H, Liu J, Nadorp B, Lasry A, Sun Z, Lai B, Rona G, Zhang J, Cammer M, Wang K, Al-Santli W, Ciantra Z, Guo Q, You J, Sengupta D, Boukhris A, Zhang H, Liu C, Cresswell P, Dahia PLM, Pagano M, Aifantis I, Wang J. Chen X, et al. Cell. 2023 Aug 31;186(18):3903-3920.e21. doi: 10.1016/j.cell.2023.07.016. Epub 2023 Aug 8. Cell. 2023. PMID: 37557169 Free PMC article.
CRL4AMBRA1 is a master regulator of D-type cyclins.
Simoneschi D, Rona G, Zhou N, Jeong YT, Jiang S, Milletti G, Arbini AA, O'Sullivan A, Wang AA, Nithikasem S, Keegan S, Siu Y, Cianfanelli V, Maiani E, Nazio F, Cecconi F, Boccalatte F, Fenyö D, Jones DR, Busino L, Pagano M. Simoneschi D, et al. Nature. 2021 Apr;592(7856):789-793. doi: 10.1038/s41586-021-03445-y. Epub 2021 Apr 14. Nature. 2021. PMID: 33854235 Free PMC article.
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.
Maiani E, Milletti G, Nazio F, Holdgaard SG, Bartkova J, Rizza S, Cianfanelli V, Lorente M, Simoneschi D, Di Marco M, D'Acunzo P, Di Leo L, Rasmussen R, Montagna C, Raciti M, De Stefanis C, Gabicagogeascoa E, Rona G, Salvador N, Pupo E, Merchut-Maya JM, Daniel CJ, Carinci M, Cesarini V, O'sullivan A, Jeong YT, Bordi M, Russo F, Campello S, Gallo A, Filomeni G, Lanzetti L, Sears RC, Hamerlik P, Bartolazzi A, Hynds RE, Pearce DR, Swanton C, Pagano M, Velasco G, Papaleo E, De Zio D, Maya-Mendoza A, Locatelli F, Bartek J, Cecconi F. Maiani E, et al. Nature. 2021 Apr;592(7856):799-803. doi: 10.1038/s41586-021-03422-5. Epub 2021 Apr 14. Nature. 2021. PMID: 33854232 Free PMC article.
CDK-independent role of D-type cyclins in regulating DNA mismatch repair.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M. Rona G, et al. Mol Cell. 2024 Apr 4;84(7):1224-1242.e13. doi: 10.1016/j.molcel.2024.02.010. Epub 2024 Mar 7. Mol Cell. 2024. PMID: 38458201 Free article.
PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4.
Nguyen-Dien GT, Townsend B, Kulkarni PG, Kozul KL, Ooi SS, Eldershaw DN, Weeratunga S, Liu M, Jones MJ, Millard SS, Ng DC, Pagano M, Bonfim-Melo A, Schneider T, Komander D, Lazarou M, Collins BM, Pagan JK. Nguyen-Dien GT, et al. EMBO Rep. 2024 Aug;25(8):3324-3347. doi: 10.1038/s44319-024-00181-y. Epub 2024 Jul 11. EMBO Rep. 2024. PMID: 38992176 Free PMC article.
24 results