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GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle.
Marcotte GR, Miller MJ, Kunz HE, Ryan ZC, Strub MD, Vanderboom PM, Heppelmann CJ, Chau S, Von Ruff ZD, Kilroe SP, McKeen AT, Dierdorff JM, Stern JI, Nath KA, Grueter CE, Lira VA, Judge AR, Rasmussen BB, Nair KS, Lanza IR, Ebert SM, Adams CM. Marcotte GR, et al. JCI Insight. 2023 Nov 22;8(22):e171772. doi: 10.1172/jci.insight.171772. JCI Insight. 2023. PMID: 37815864 Free PMC article.
The transcription regulator ATF4 is a mediator of skeletal muscle aging.
Miller MJ, Marcotte GR, Basisty N, Wehrfritz C, Ryan ZC, Strub MD, McKeen AT, Stern JI, Nath KA, Rasmussen BB, Judge AR, Schilling B, Ebert SM, Adams CM. Miller MJ, et al. Geroscience. 2023 Aug;45(4):2525-2543. doi: 10.1007/s11357-023-00772-y. Epub 2023 Apr 4. Geroscience. 2023. PMID: 37014538 Free PMC article.
An investigation of p53 in skeletal muscle aging.
Ebert SM, Dierdorff JM, Meyerholz DK, Bullard SA, Al-Zougbi A, DeLau AD, Tomcheck KC, Skopec ZP, Marcotte GR, Bodine SC, Adams CM. Ebert SM, et al. J Appl Physiol (1985). 2019 Oct 1;127(4):1075-1084. doi: 10.1152/japplphysiol.00363.2019. Epub 2019 Aug 29. J Appl Physiol (1985). 2019. PMID: 31465716 Free PMC article.
Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ.
Ebert SM, Bullard SA, Basisty N, Marcotte GR, Skopec ZP, Dierdorff JM, Al-Zougbi A, Tomcheck KC, DeLau AD, Rathmacher JA, Bodine SC, Schilling B, Adams CM. Ebert SM, et al. J Biol Chem. 2020 Feb 28;295(9):2787-2803. doi: 10.1074/jbc.RA119.012095. Epub 2020 Jan 17. J Biol Chem. 2020. PMID: 31953319 Free PMC article.