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A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner.
Nat Biotechnol. 2009 Dec;27(12):1186-90. doi: 10.1038/nbt.1588.
Nat Biotechnol. 2009.
PMID: 19915550
Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose.
Geething NC, To W, Spink BJ, Scholle MD, Wang CW, Yin Y, Yao Y, Schellenberger V, Cleland JL, Stemmer WP, Silverman J.
Geething NC, et al.
PLoS One. 2010 Apr 14;5(4):e10175. doi: 10.1371/journal.pone.0010175.
PLoS One. 2010.
PMID: 20418955
Free PMC article.
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