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FOXO transcription factors as therapeutic targets in human diseases.
Orea-Soufi A, Paik J, Bragança J, Donlon TA, Willcox BJ, Link W. Orea-Soufi A, et al. Trends Pharmacol Sci. 2022 Dec;43(12):1070-1084. doi: 10.1016/j.tips.2022.09.010. Epub 2022 Oct 21. Trends Pharmacol Sci. 2022. PMID: 36280450 Review.
FOXO protects against age-progressive axonal degeneration.
Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J. Hwang I, et al. Aging Cell. 2018 Feb;17(1):e12701. doi: 10.1111/acel.12701. Epub 2017 Nov 26. Aging Cell. 2018. PMID: 29178390 Free PMC article.
CIC is a critical regulator of neuronal differentiation.
Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. Hwang I, et al. JCI Insight. 2020 May 7;5(9):e135826. doi: 10.1172/jci.insight.135826. JCI Insight. 2020. PMID: 32229723 Free PMC article.