RF1 NS127925/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2023	5
2024	4

1

RBFOX2 recognizes N⁶-methyladenosine to suppress transcription and block myeloid leukaemia differentiation.

Dou X, Xiao Y, Shen C, Wang K, Wu T, Liu C, Li Y, Yu X, Liu J, Dai Q, Pajdzik K, Ye C, Ge R, Gao B, Yu J, Sun S, Chen M, Chen J, He C. Dou X, et al. Nat Cell Biol. 2023 Sep;25(9):1359-1368. doi: 10.1038/s41556-023-01213-w. Epub 2023 Aug 28. Nat Cell Biol. 2023. PMID: 37640841 Free PMC article.

2

Translation dysregulation in neurodegenerative diseases: a focus on ALS.

Wang S, Sun S. Wang S, et al. Mol Neurodegener. 2023 Aug 25;18(1):58. doi: 10.1186/s13024-023-00642-3. Mol Neurodegener. 2023. PMID: 37626421 Free PMC article. Review.

3

Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS.

Wu R, Ye Y, Dong D, Zhang Z, Wang S, Li Y, Wright N, Redding-Ochoa J, Chang K, Xu S, Tu X, Zhu C, Ostrow LW, Roca X, Troncoso JC, Wu B, Sun S. Wu R, et al. Neuron. 2024 Oct 23;112(20):3434-3451.e11. doi: 10.1016/j.neuron.2024.07.025. Epub 2024 Aug 23. Neuron. 2024. PMID: 39181135

4

Globally reduced N⁶-methyladenosine (m⁶A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration.

Li Y, Dou X, Liu J, Xiao Y, Zhang Z, Hayes L, Wu R, Fu X, Ye Y, Yang B, Ostrow LW, He C, Sun S. Li Y, et al. Nat Neurosci. 2023 Aug;26(8):1328-1338. doi: 10.1038/s41593-023-01374-9. Epub 2023 Jun 26. Nat Neurosci. 2023. PMID: 37365312 Free PMC article.

5

Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD.

Latallo MJ, Wang S, Dong D, Nelson B, Livingston NM, Wu R, Zhao N, Stasevich TJ, Bassik MC, Sun S, Wu B. Latallo MJ, et al. Nat Commun. 2023 Sep 11;14(1):5581. doi: 10.1038/s41467-023-41339-x. Nat Commun. 2023. PMID: 37696852 Free PMC article.

6

DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD.

Fu X, Zhang Z, Hayes LR, Wright N, Asbury J, Li S, Ye Y, Sun S. Fu X, et al. Exp Neurol. 2024 Jun;376:114768. doi: 10.1016/j.expneurol.2024.114768. Epub 2024 Mar 29. Exp Neurol. 2024. PMID: 38556190

7

Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons.

Dong D, Zhang Z, Li Y, Latallo MJ, Wang S, Nelson B, Wu R, Krishnan G, Gao FB, Wu B, Sun S. Dong D, et al. Sci Signal. 2024 Aug 6;17(848):eadl1030. doi: 10.1126/scisignal.adl1030. Epub 2024 Aug 6. Sci Signal. 2024. PMID: 39106320 Free PMC article.

8

Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia.

Baghel MS, Burns GD, Tsapatsis M, Mallika AP, Cruz ALF, Cao T, Chen XK, Rosa I, Marx SR, Ye Y, Sun S, Li T, Wong PC. Baghel MS, et al. bioRxiv [Preprint]. 2024 Jun 29:2024.06.26.600814. doi: 10.1101/2024.06.26.600814. bioRxiv. 2024. PMID: 38979270 Free PMC article. Preprint.

9

Linking ALS mutations to the disruption of the MHC-II pathway.

Zhang Z, Sun S. Zhang Z, et al. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2315240120. doi: 10.1073/pnas.2315240120. Epub 2023 Oct 11. Proc Natl Acad Sci U S A. 2023. PMID: 37819987 Free PMC article. No abstract available.

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