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De novo metalloprotein design.
Chalkley MJ, Mann SI, DeGrado WF. Chalkley MJ, et al. Nat Rev Chem. 2022 Jan;6(1):31-50. doi: 10.1038/s41570-021-00339-5. Epub 2021 Dec 6. Nat Rev Chem. 2022. PMID: 35811759 Free PMC article.
KRAS is vulnerable to reversible switch-II pocket engagement in cells.
Vasta JD, Peacock DM, Zheng Q, Walker JA, Zhang Z, Zimprich CA, Thomas MR, Beck MT, Binkowski BF, Corona CR, Robers MB, Shokat KM. Vasta JD, et al. Nat Chem Biol. 2022 Jun;18(6):596-604. doi: 10.1038/s41589-022-00985-w. Epub 2022 Mar 21. Nat Chem Biol. 2022. PMID: 35314814 Free PMC article.
Deep learning guided design of dynamic proteins.
Guo AB, Akpinaroglu D, Kelly MJS, Kortemme T. Guo AB, et al. bioRxiv [Preprint]. 2024 Jul 19:2024.07.17.603962. doi: 10.1101/2024.07.17.603962. bioRxiv. 2024. PMID: 39071443 Free PMC article. Preprint.
18 results