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Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.
Structure. 2011 May 11;19(5):675-90. doi: 10.1016/j.str.2011.02.016.
Structure. 2011.
PMID: 21565702
Free PMC article.
Price to be paid for two-metal catalysis: magnesium ions that accelerate chemistry unavoidably limit product release from a protein kinase.
Jacobsen DM, Bao ZQ, O'Brien P, Brooks CL 3rd, Young MA.
Jacobsen DM, et al.
J Am Chem Soc. 2012 Sep 19;134(37):15357-70. doi: 10.1021/ja304419t. Epub 2012 Sep 7.
J Am Chem Soc. 2012.
PMID: 22891849
Free PMC article.
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