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Lysosome quality control in health and neurodegenerative diseases.
Ferrari V, Tedesco B, Cozzi M, Chierichetti M, Casarotto E, Pramaggiore P, Cornaggia L, Mohamed A, Patelli G, Piccolella M, Cristofani R, Crippa V, Galbiati M, Poletti A, Rusmini P. Ferrari V, et al. Cell Mol Biol Lett. 2024 Sep 5;29(1):116. doi: 10.1186/s11658-024-00633-2. Cell Mol Biol Lett. 2024. PMID: 39237893 Free PMC article. Review.
Multiple Roles of Transforming Growth Factor Beta in Amyotrophic Lateral Sclerosis.
Galbiati M, Crippa V, Rusmini P, Cristofani R, Messi E, Piccolella M, Tedesco B, Ferrari V, Casarotto E, Chierichetti M, Poletti A. Galbiati M, et al. Int J Mol Sci. 2020 Jun 16;21(12):4291. doi: 10.3390/ijms21124291. Int J Mol Sci. 2020. PMID: 32560258 Free PMC article. Review.
This motor neuronal disease is non-cell autonomous, as it affects not only motor neurons but also the surrounding glial cells, and the target skeletal muscle fibers. Here, we analyze the multiple roles of TGFB in these cell types, and how TGFB signaling is altered in ALS t …
This motor neuronal disease is non-cell autonomous, as it affects not only motor neurons but also the surrounding glial cells, and the ta …
The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer.
Cristofani R, Piccolella M, Crippa V, Tedesco B, Montagnani Marelli M, Poletti A, Moretti RM. Cristofani R, et al. Cells. 2021 Feb 5;10(2):335. doi: 10.3390/cells10020335. Cells. 2021. PMID: 33562660 Free PMC article. Review.
Despite the fact the mechanisms of HSPB8-mediated CASA activation in tumors need further studies, HSPB8 could represent an important factor in cancer induction and progression and it may be a potential target for anticancer treatment in specific types of cancer. In this re …
Despite the fact the mechanisms of HSPB8-mediated CASA activation in tumors need further studies, HSPB8 could represent an important factor …
The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases.
Tedesco B, Ferrari V, Cozzi M, Chierichetti M, Casarotto E, Pramaggiore P, Mina F, Galbiati M, Rusmini P, Crippa V, Cristofani R, Poletti A. Tedesco B, et al. Int J Mol Sci. 2022 Oct 4;23(19):11759. doi: 10.3390/ijms231911759. Int J Mol Sci. 2022. PMID: 36233058 Free PMC article. Review.
Here, we discuss the role of HSPBs in MNDs and which HSPBs may represent a valid target for therapeutic purposes....
Here, we discuss the role of HSPBs in MNDs and which HSPBs may represent a valid target for therapeutic purposes....
Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy.
Ferrari V, Cristofani R, Tedesco B, Crippa V, Chierichetti M, Casarotto E, Cozzi M, Mina F, Piccolella M, Galbiati M, Rusmini P, Poletti A. Ferrari V, et al. Int J Mol Sci. 2022 Feb 9;23(4):1939. doi: 10.3390/ijms23041939. Int J Mol Sci. 2022. PMID: 35216053 Free PMC article. Review.
Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives.
Rusmini P, Cristofani R, Tedesco B, Ferrari V, Messi E, Piccolella M, Casarotto E, Chierichetti M, Cicardi ME, Galbiati M, Geroni C, Lombardi P, Crippa V, Poletti A. Rusmini P, et al. Int J Mol Sci. 2020 May 13;21(10):3443. doi: 10.3390/ijms21103443. Int J Mol Sci. 2020. PMID: 32414108 Free PMC article.
Mutant proteins that misfold are potentially neurotoxic, thus strategies aimed at preventing their aggregation or at enhancing their clearance are emerging as interesting therapeutic targets for NDs. METHODS: We tested the natural alkaloid berberine (BBR) and some derivati …
Mutant proteins that misfold are potentially neurotoxic, thus strategies aimed at preventing their aggregation or at enhancing their clearan …