Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain.
Wang M, Zhang L, Novak SW, Yu J, Gallina IS, Xu LL, Lim CK, Fernandes S, Shokhirev MN, Williams AE, Saxena MD, Coorapati S, Parylak SL, Quintero C, Molina E, Andrade LR, Manor U, Gage FH.
Wang M, et al.
Nat Biotechnol. 2025 Jan;43(1):52-62. doi: 10.1038/s41587-024-02157-8. Epub 2024 Feb 28.
Nat Biotechnol. 2025.
PMID: 38418648
Free PMC article.
Astrocytes, the most abundant glial cell type in the brain, are underrepresented in traditional cortical organoid models due to the delayed onset of cortical gliogenesis. ...
Astrocytes, the most abundant glial cell type in the brain, are underrepresented in traditional cortical organoid models due to the d …