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Etravirine in CSF is highly protein bound.
Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S; CHARTER Group. Nguyen A, et al. J Antimicrob Chemother. 2013 May;68(5):1161-8. doi: 10.1093/jac/dks517. Epub 2013 Jan 20. J Antimicrob Chemother. 2013. PMID: 23335197 Free PMC article.
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study.
Heaton RK, Clifford DB, Franklin DR Jr, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Rivera-Mindt M, Vigil OR, Taylor MJ, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I; CHARTER Group. Heaton RK, et al. Neurology. 2010 Dec 7;75(23):2087-96. doi: 10.1212/WNL.0b013e318200d727. Neurology. 2010. PMID: 21135382 Free PMC article.
Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline.
Grant I, Franklin DR Jr, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Heaton RK; CHARTER Group. Grant I, et al. Neurology. 2014 Jun 10;82(23):2055-62. doi: 10.1212/WNL.0000000000000492. Epub 2014 May 9. Neurology. 2014. PMID: 24814848 Free PMC article.