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Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications.
Nerurkar A, Nguyen T, Wang S, Bhatt U, Li K, Li Y, Ding P, Seidl FJ, Holan M, Lee J, Widjaja T, Wei ZL, Sadlowski C, Sperandio D, McGee LR, Youngblood B, Schwartz N, Gehlert D, Medina JC. Nerurkar A, et al. Bioorg Med Chem Lett. 2023 Aug 15;92:129405. doi: 10.1016/j.bmcl.2023.129405. Epub 2023 Jul 5. Bioorg Med Chem Lett. 2023. PMID: 37414346 Free PMC article.
A Novel Maintenance Therapeutic for Opioid Use Disorder.
Youngblood B, Li K, Gehlert DR, Medina JC, Schwartz N. Youngblood B, et al. J Pharmacol Exp Ther. 2021 Aug;378(2):133-145. doi: 10.1124/jpet.120.000214. Epub 2021 May 19. J Pharmacol Exp Ther. 2021. PMID: 34011529 Free PMC article.