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The DNA Methyltransferase Inhibitor 5-Aza-4'-thio-2'-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development.
Cancer Res. 2024 Aug 1;84(15):2518-2532. doi: 10.1158/0008-5472.CAN-23-2785.
Cancer Res. 2024.
PMID: 38832931
Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.
Matsukawa T, Yin M, Baslan T, Chung YJ, Cao D, Bertoli R, Zhu YJ, Walker RL, Freeland A, Knudsen E, Lowe SW, Meltzer PS, Aplan PD.
Matsukawa T, et al.
FASEB J. 2022 Sep;36(9):e22430. doi: 10.1096/fj.202200061RR.
FASEB J. 2022.
PMID: 35920299
Free PMC article.
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A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
Yin M, Baslan T, Walker RL, Zhu YJ, Freeland A, Matsukawa T, Sridharan S, Nussenzweig A, Pruitt SC, Lowe SW, Meltzer PS, Aplan PD.
Yin M, et al.
JCI Insight. 2019 Dec 5;4(23):e131434. doi: 10.1172/jci.insight.131434.
JCI Insight. 2019.
PMID: 31622281
Free PMC article.
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