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Year Number of Results
1969 1
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1982 3
1983 1
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1986 3
1987 2
1988 1
1989 5
1990 5
1991 2
1992 8
1993 8
1994 10
1995 6
1996 8
1997 8
1998 10
1999 5
2000 4
2001 6
2002 5
2003 4
2004 3
2005 3
2006 9
2007 16
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2011 10
2012 6
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2025 0

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237 results

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Page 1
Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Śliwa-Tytko P, Kaczmarska A, Lejman M, Zawitkowska J. Śliwa-Tytko P, et al. Int J Mol Sci. 2022 May 15;23(10):5515. doi: 10.3390/ijms23105515. Int J Mol Sci. 2022. PMID: 35628334 Free PMC article. Review.
The most neurotoxical chemotherapeutics are L-asparaginase (L-ASP), methotrexate (MTX), vincristine (VCR), and nelarabine (Ara-G). Neurotoxicity associated with methotrexate (MTX-NT) occurs in 3-7% of children treated for ALL and is characterized by seizures, stroke …
The most neurotoxical chemotherapeutics are L-asparaginase (L-ASP), methotrexate (MTX), vincristine (VCR), and nelarabine (Ara-G …
Nelarabine.
Sanford M, Lyseng-Williamson KA. Sanford M, et al. Drugs. 2008;68(4):439-47. doi: 10.2165/00003495-200868040-00004. Drugs. 2008. PMID: 18318562 Review.
Nelarabine is an anticancer prodrug of arabinofuranosylguanine (ara-G), which is metabolized in cells to the cytotoxic metabolite ara-G triphosphate (ara-GTP). ...
Nelarabine is an anticancer prodrug of arabinofuranosylguanine (ara-G), which is metabolized in cells to the cytotoxic metabol …
Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma.
Abaza Y, M Kantarjian H, Faderl S, Jabbour E, Jain N, Thomas D, Kadia T, Borthakur G, D Khoury J, Burger J, Wierda W, O'Brien S, Konopleva M, Ferrajoli A, Kebriaei P, Dabaja B, Kornblau S, Alvarado Y, Daver N, Pemmaraju N, Bose P, Thompson P, Al Azzawi H, Kelly M, Garris R, Jain P, Garcia-Manero G, Cortes J, Ravandi F. Abaza Y, et al. Am J Hematol. 2018 Jan;93(1):91-99. doi: 10.1002/ajh.24947. Epub 2017 Nov 3. Am J Hematol. 2018. PMID: 29047158 Free article.
Nelarabine, a water soluble prodrug of 9-beta-D-arabinofuranosylguanine (ara-G), is a T-cell specific purine nucleoside analogue. Given its activity in relapsed and refractory T acute lymphoblastic leukemia (T-ALL) and T lymphoblastic lymphoma (T-LBL), we sought to …
Nelarabine, a water soluble prodrug of 9-beta-D-arabinofuranosylguanine (ara-G), is a T-cell specific purine nucleoside analog …
In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia.
Homminga I, Zwaan CM, Manz CY, Parker C, Bantia S, Smits WK, Higginbotham F, Pieters R, Meijerink JP. Homminga I, et al. Blood. 2011 Aug 25;118(8):2184-90. doi: 10.1182/blood-2011-02-337840. Epub 2011 Jul 5. Blood. 2011. PMID: 21730354 Free article.
Resistance to forodesine did not preclude ara-G sensitivity and vice versa, indicating that both drugs rely on different resistance mechanisms. ...The mRNA levels of the transporters ENT1 and ENT2 were higher in ara-G-sensitive than -resistant samples. …
Resistance to forodesine did not preclude ara-G sensitivity and vice versa, indicating that both drugs rely on different resis …
Nelarabine: a nucleoside analog with efficacy in T-cell and other leukemias.
Kisor DF. Kisor DF. Ann Pharmacother. 2005 Jun;39(6):1056-63. doi: 10.1345/aph.1E453. Epub 2005 May 3. Ann Pharmacother. 2005. PMID: 15870141 Review.
DATA SYNTHESIS: Nelarabine is the water-soluble, 6-methoxy analog of 9-beta-D-ara-G. Nelarabine is readily converted to ara-G by endogenous adenosine deaminase. The half-life of nelarabine is approximately 15 minutes compared with 2-4 hours for ara …
DATA SYNTHESIS: Nelarabine is the water-soluble, 6-methoxy analog of 9-beta-D-ara-G. Nelarabine is readily converted to ara …
Dietary ARA Improves COX Activity in Broodstock and Offspring Survival Fitness of a Model Organism (Medaka Oryzias latipes).
Kowalska A, Kamaszewski M, Czarnowska-Kujawska M, Podlasz P, Kowalski RK. Kowalska A, et al. Animals (Basel). 2020 Nov 21;10(11):2174. doi: 10.3390/ani10112174. Animals (Basel). 2020. PMID: 33233393 Free PMC article.
After spawn induction and dietary exposure to 4 mg ARA g(-1) TFA, broodstock were fed a diet containing ARA in the amounts: 4 (continued, as control), 5, 14 and 23 mg g(-1) TFA. ...The highest sperm motility parameters were observed in males fed a diet containing 23 …
After spawn induction and dietary exposure to 4 mg ARA g(-1) TFA, broodstock were fed a diet containing ARA in the amounts: 4 …
Monkeypox virus: A potential pandemic?
Tarique D, Siddiqui AA, Ara G. Tarique D, et al. J Pak Med Assoc. 2023 Feb;73(2):460-461. doi: 10.47391/JPMA.7224. J Pak Med Assoc. 2023. PMID: 36800762 Free article. No abstract available.
Strengthening dengue control in Pakistan.
Saleem M, Sheikh A, Nawaz H, Ara G. Saleem M, et al. East Mediterr Health J. 2023 Dec 21;29(12):921-923. doi: 10.26719/emhj.23.099. East Mediterr Health J. 2023. PMID: 38279860 Free article. No abstract available.
Nelarabine in the treatment of pediatric and adult patients with T-cell acute lymphoblastic leukemia and lymphoma.
Kadia TM, Gandhi V. Kadia TM, et al. Expert Rev Hematol. 2017 Jan;10(1):1-8. doi: 10.1080/17474086.2017.1262757. Epub 2016 Dec 8. Expert Rev Hematol. 2017. PMID: 27869523 Free PMC article. Review.
Based on observations in patients with purine nucleoside phosphorylase (PNP) deficiency, a guanosine nucleoside analogue, arabinosylguanine (ara-G) was developed that provided T-cell specificity. Nelarabine was developed as the water-soluble, clinically useful-prodr …
Based on observations in patients with purine nucleoside phosphorylase (PNP) deficiency, a guanosine nucleoside analogue, arabinosylguanine …
Nelarabine in the treatment of refractory T-cell malignant diseases.
Kline J, Larson RA. Kline J, et al. Expert Opin Pharmacother. 2006 Sep;7(13):1791-9. doi: 10.1517/14656566.7.13.1791. Expert Opin Pharmacother. 2006. PMID: 16925505 Review.
Nelarabine (2-amino-9-beta-D-arabinosyl-6-methoxy-9H-guanine), a synthesised guanosine nucleoside and water-soluble prodrug of ara-G (9-beta-D-arabinofuranosylguanine), has recently been approved by the FDA for the treatment of relapsed/refractory T-cell acute lymph …
Nelarabine (2-amino-9-beta-D-arabinosyl-6-methoxy-9H-guanine), a synthesised guanosine nucleoside and water-soluble prodrug of ara- …
237 results