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Lipid nanoparticle delivery of TALEN mRNA targeting LPA causes gene disruption and plasma lipoprotein(a) reduction in transgenic mice.
Garcia DA, Pierre AF, Quirino L, Acharya G, Vasudevan A, Pei Y, Chung E, Chang JYH, Lee S, Endow M, Kuakini K, Bresnahan M, Chumpitaz M, Rajappan K, Parker S, Chivukula P, Boehme SA, Diaz-Trelles R. Garcia DA, et al. Among authors: chumpitaz m. Mol Ther. 2025 Jan 8;33(1):90-103. doi: 10.1016/j.ymthe.2024.11.020. Epub 2024 Nov 19. Mol Ther. 2025. PMID: 39563033 Free article.