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Page 1
Showing results for damgo ci
Search for Dambo CI instead (2 results)
Fentanyl induces autism-like behaviours in mice by hypermethylation of the glutamate receptor gene Grin2b.
Sheng Z, Liu Q, Cheng C, Li M, Barash J, Kofke WA, Shen Y, Xie Z. Sheng Z, et al. Br J Anaesth. 2022 Oct;129(4):544-554. doi: 10.1016/j.bja.2022.04.027. Epub 2022 Jun 11. Br J Anaesth. 2022. PMID: 35697546 Free article.
In the specific activation and rescue experiments, we injected the mu opioid receptor agonist [D-Ala,(2) N-MePhe,(4) Gly-ol]-enkephalin (DAMGO) or Grin2b overexpression lentivirus into the anterior cingulate cortex of male mice. ...The mu-opioid receptor antagonist …
In the specific activation and rescue experiments, we injected the mu opioid receptor agonist [D-Ala,(2) N-MePhe,(4) Gly-ol]-enkephalin …
Age-related changes in peripheral nociceptor function.
Jennings EM, Sullivan LC, Jamshidi RJ, LoCoco PM, Smith HR, Chavera TS, Berg KA, Clarke WP. Jennings EM, et al. Neuropharmacology. 2022 Sep 15;216:109187. doi: 10.1016/j.neuropharm.2022.109187. Epub 2022 Jul 12. Neuropharmacology. 2022. PMID: 35835212
Intraplantar injection of TRP channel activators, capsaicin (TRPV1), mustard oil (TRPA1) and menthol (TRPM8) each resulted in greater mechanical allodynia in aged versus young rats and capsaicin-induced heat allodynia was also greater in aged rats. A treatment-induced …
Intraplantar injection of TRP channel activators, capsaicin (TRPV1), mustard oil (TRPA1) and menthol (TRPM8) each resulted in greater mechan …
Persistent inflammation selectively activates opioid-sensitive phasic-firing neurons within the vlPAG.
McPherson KB, Bouchet CA, Coutens B, Ingram SL. McPherson KB, et al. J Neurophysiol. 2023 May 1;129(5):1237-1248. doi: 10.1152/jn.00016.2023. Epub 2023 Apr 19. J Neurophysiol. 2023. PMID: 37073984 Free PMC article.
The ventrolateral periaqueductal gray (vlPAG) is a key brain area within the descending pain modulatory pathway and an important target for opioid-induced analgesia. The vlPAG contains heterogeneous neurons with respect to neurotransmitter content, receptor and channel exp …
The ventrolateral periaqueductal gray (vlPAG) is a key brain area within the descending pain modulatory pathway and an important target for …
Optimization binding studies of opioid receptors, saturation and competition, using [(3)H]-DAMGO.
Khoramjouy M, Ahmadi F, Faizi M, Shahhosseini S. Khoramjouy M, et al. Pharmacol Rep. 2021 Oct;73(5):1390-1395. doi: 10.1007/s43440-021-00265-9. Epub 2021 Apr 19. Pharmacol Rep. 2021. PMID: 33871815
METHODS: We used the midbrain and brainstem of naltrexone-treated rats as a source of -opioid receptors, and [(3)H]-DAMGO as the radioligand. Naloxone was also used to determine non-specific binding. A given amount of membrane protein was incubated with an increasing amoun …
METHODS: We used the midbrain and brainstem of naltrexone-treated rats as a source of -opioid receptors, and [(3)H]-DAMGO as the radi …
CI-977, a novel and selective agonist for the kappa-opioid receptor.
Hunter JC, Leighton GE, Meecham KG, Boyle SJ, Horwell DC, Rees DC, Hughes J. Hunter JC, et al. Br J Pharmacol. 1990 Sep;101(1):183-9. doi: 10.1111/j.1476-5381.1990.tb12110.x. Br J Pharmacol. 1990. PMID: 2178014 Free PMC article.
In a radioligand binding studies, with guinea-pig forebrain homogenates, CI-977 bound with high affinity to [3H]-U69593-labelled kappa-sites (Ki = 0.11 nM) but with low affinity to [3H]-[D-Ala2, MePhe4, Gly-ol5] enkephalin (DAMGO) labelled mu-sites (Ki = 99 n …
In a radioligand binding studies, with guinea-pig forebrain homogenates, CI-977 bound with high affinity to [3H]-U69593-labelled kapp …
Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.
Wang Z, Jiang C, Yao H, Chen O, Rahman S, Gu Y, Zhao J, Huh Y, Ji RR. Wang Z, et al. Brain. 2021 Mar 3;144(2):665-681. doi: 10.1093/brain/awaa430. Brain. 2021. PMID: 33367648
Loss of MOR in somatostatin+ interneurons and TRPV1+ sensory neurons did not affect morphine-induced itch but impaired morphine-induced antinociception. In situ hybridization revealed Oprm1 expression in 30% of inhibitory and 20% of excitatory interneurons in the sp …
Loss of MOR in somatostatin+ interneurons and TRPV1+ sensory neurons did not affect morphine-induced itch but impaired morphine-in …
Intra-amygdalar injection of DAMGO: effects on c-Fos levels in brain sites associated with feeding behavior.
Levine AS, Olszewski PK, Mullett MA, Pomonis JD, Grace MK, Kotz CM, Billington CJ. Levine AS, et al. Brain Res. 2004 Jul 23;1015(1-2):9-14. doi: 10.1016/j.brainres.2004.04.039. Brain Res. 2004. PMID: 15223361
We also studied the effect of CeA-injected DAMGO on LiCl-induced increases in c-Fos IR in the amygdala. As was expected, intra-CeA injection of DAMGO increased food intake of rats over a 4-h period. ...We also found that intra-CeA injection of DAMGO, p …
We also studied the effect of CeA-injected DAMGO on LiCl-induced increases in c-Fos IR in the amygdala. As was expected, intra …
DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.
Zhang RX, Zhang M, Li A, Pan L, Berman BM, Ren K, Lao L. Zhang RX, et al. Neuroscience. 2013 Nov 12;252:359-66. doi: 10.1016/j.neuroscience.2013.08.030. Epub 2013 Aug 28. Neuroscience. 2013. PMID: 23994597 Free PMC article.
We hypothesized that systemic morphine before a post-conditioning test would more potently attenuate the affective aspect compared to the sensory component and that [d-Ala2-N-Me-Phe4, Gly-ol5]-enkephalin (DAMGO), a mu-selective opioid receptor agonist, injected into …
We hypothesized that systemic morphine before a post-conditioning test would more potently attenuate the affective aspect compared to the se …
DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens.
Al-Khrasani M, Spetea M, Friedmann T, Riba P, Király K, Schmidhammer H, Furst S. Al-Khrasani M, et al. Brain Res Bull. 2007 Oct 19;74(5):369-75. doi: 10.1016/j.brainresbull.2007.07.008. Epub 2007 Jul 30. Brain Res Bull. 2007. PMID: 17845912
Here, the antinociceptive effects of MOR agonists, the 6beta-glycine derivative of 14-O-methyloxymorphone (HS-731), DAMGO and morphine were evaluated in a mouse model of visceral pain. The abdominal acetic acid-induced writhing test was used to examine the periphera …
Here, the antinociceptive effects of MOR agonists, the 6beta-glycine derivative of 14-O-methyloxymorphone (HS-731), DAMGO and morphin …
Brief Opioid Exposure Paradoxically Augments Primary Afferent Input to Spinal Excitatory Neurons via α2δ-1-Dependent Presynaptic NMDA Receptors.
Chen SR, Chen H, Jin D, Pan HL. Chen SR, et al. J Neurosci. 2022 Dec 14;42(50):9315-9329. doi: 10.1523/JNEUROSCI.1704-22.2022. Epub 2022 Nov 15. J Neurosci. 2022. PMID: 36379705 Free PMC article.
Spinal cord slice recordings revealed that -opioid receptor (MOR) stimulation with DAMGO initially inhibited dorsal root-evoked EPSCs in 87% VGluT2 neurons and subsequently induced LTP in 49% of these neurons. ...Furthermore, conditional Grin1 knockout in dorsal roo …
Spinal cord slice recordings revealed that -opioid receptor (MOR) stimulation with DAMGO initially inhibited dorsal root-evoked EPSCs …
200 results