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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1965 1
1969 1
1970 2
1971 1
1972 2
1975 2
1976 3
1977 3
1978 4
1979 7
1980 5
1981 6
1982 2
1983 6
1984 6
1985 2
1986 4
1987 5
1988 4
1989 2
1991 3
1992 8
1993 8
1994 5
1995 5
1996 5
1997 8
1998 2
1999 1
2000 3
2001 9
2002 5
2003 1
2004 1
2005 2
2007 5
2008 2
2009 7
2010 7
2011 5
2012 3
2013 1
2014 7
2015 6
2016 6
2017 13
2018 7
2019 11
2020 7
2021 8
2022 13
2023 10
2024 11

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254 results

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Page 1
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Kerres N, Steurer S, Schlager S, Bader G, Berger H, Caligiuri M, Dank C, Engen JR, Ettmayer P, Fischerauer B, Flotzinger G, Gerlach D, Gerstberger T, Gmaschitz T, Greb P, Han B, Heyes E, Iacob RE, Kessler D, Kölle H, Lamarre L, Lancia DR, Lucas S, Mayer M, Mayr K, Mischerikow N, Mück K, Peinsipp C, Petermann O, Reiser U, Rudolph D, Rumpel K, Salomon C, Scharn D, Schnitzer R, Schrenk A, Schweifer N, Thompson D, Traxler E, Varecka R, Voss T, Weiss-Puxbaum A, Winkler S, Zheng X, Zoephel A, Kraut N, McConnell D, Pearson M, Koegl M. Kerres N, et al. Among authors: gerlach d. Cell Rep. 2017 Sep 19;20(12):2860-2875. doi: 10.1016/j.celrep.2017.08.081. Cell Rep. 2017. PMID: 28930682 Free article.
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Hofmann MH, Gmachl M, Ramharter J, Savarese F, Gerlach D, Marszalek JR, Sanderson MP, Kessler D, Trapani F, Arnhof H, Rumpel K, Botesteanu DA, Ettmayer P, Gerstberger T, Kofink C, Wunberg T, Zoephel A, Fu SC, Teh JL, Böttcher J, Pototschnig N, Schachinger F, Schipany K, Lieb S, Vellano CP, O'Connell JC, Mendes RL, Moll J, Petronczki M, Heffernan TP, Pearson M, McConnell DB, Kraut N. Hofmann MH, et al. Among authors: gerlach d. Cancer Discov. 2021 Jan;11(1):142-157. doi: 10.1158/2159-8290.CD-20-0142. Epub 2020 Aug 19. Cancer Discov. 2021. PMID: 32816843 Free PMC article.
Journal Club.
Graw J, Engelhardt H, Küsel K, Kruck D, Tinnefeld P, Sander J, Robatzek S, Schäberle TF, Aichane K, Brochado AR, Gerlach D. Graw J, et al. Among authors: gerlach d. Biospektrum (Heidelb). 2021;27(4):400-405. doi: 10.1007/s12268-021-1601-9. Epub 2021 Jun 26. Biospektrum (Heidelb). 2021. PMID: 34219984 Free PMC article. German. No abstract available.
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.
Wilding B, Scharn D, Böse D, Baum A, Santoro V, Chetta P, Schnitzer R, Botesteanu DA, Reiser C, Kornigg S, Knesl P, Hörmann A, Köferle A, Corcokovic M, Lieb S, Scholz G, Bruchhaus J, Spina M, Balla J, Peric-Simov B, Zimmer J, Mitzner S, Fett TN, Beran A, Lamarre L, Gerstberger T, Gerlach D, Bauer M, Bergner A, Schlattl A, Bader G, Treu M, Engelhardt H, Zahn S, Fuchs JE, Zuber J, Ettmayer P, Pearson M, Petronczki M, Kraut N, McConnell DB, Solca F, Neumüller RA. Wilding B, et al. Among authors: gerlach d. Nat Cancer. 2022 Jul;3(7):821-836. doi: 10.1038/s43018-022-00412-y. Epub 2022 Jul 26. Nat Cancer. 2022. PMID: 35883003
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance.
Thatikonda V, Lyu H, Jurado S, Kostyrko K, Bristow CA, Albrecht C, Alpar D, Arnhof H, Bergner O, Bosch K, Feng N, Gao S, Gerlach D, Gmachl M, Hinkel M, Lieb S, Jeschko A, Machado AA, Madensky T, Marszalek ED, Mahendra M, Melo-Zainzinger G, Molkentine JM, Jaeger PA, Peng DH, Schenk RL, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano CP, Petronczki M, Kraut N, Heffernan TP, Marszalek JR, Pearson M, Waizenegger IC, Hofmann MH. Thatikonda V, et al. Among authors: gerlach d. Nat Cancer. 2024 Sep;5(9):1352-1370. doi: 10.1038/s43018-024-00800-6. Epub 2024 Aug 5. Nat Cancer. 2024. PMID: 39103541 Free PMC article.
Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers.
Wilding B, Woelflingseder L, Baum A, Chylinski K, Vainorius G, Gibson N, Waizenegger IC, Gerlach D, Augsten M, Spreitzer F, Shirai Y, Ikegami M, Tilandyova S, Scharn D, Pearson MA, Popow J, Obenauf AC, Yamamoto N, Kondo S, Opdam FL, Bruining A, Kohsaka S, Kraut N, Heymach JV, Solca F, Neumuller RA. Wilding B, et al. Among authors: gerlach d. Cancer Discov. 2024 Sep 9. doi: 10.1158/2159-8290.CD-24-0306. Online ahead of print. Cancer Discov. 2024. PMID: 39248702
Temperate Phages of Staphylococcus aureus.
Ingmer H, Gerlach D, Wolz C. Ingmer H, et al. Among authors: gerlach d. Microbiol Spectr. 2019 Sep;7(5):10.1128/microbiolspec.gpp3-0058-2018. doi: 10.1128/microbiolspec.GPP3-0058-2018. Microbiol Spectr. 2019. PMID: 31562736 Free PMC article. Review.
Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma.
Marasco M, Kumar D, Seale T, Borrego SG, Kaplun E, Aricescu I, Cole S, Qeriqi B, Qiu J, Chen X, Bahr A, Fidele D, Hofmann MH, Gerlach D, Savarese F, Merghoub T, Wolchok JD, Yao Z, de Stanchina E, Solit D, Misale S, Rosen N. Marasco M, et al. Among authors: gerlach d. Cell Rep Med. 2024 Nov 19;5(11):101818. doi: 10.1016/j.xcrm.2024.101818. Epub 2024 Nov 1. Cell Rep Med. 2024. PMID: 39488215 Free PMC article.
254 results