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Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer.
Hosseini A, Lindholm HT, Chen R, Mehdipour P, Marhon SA, Ishak CA, Moore PC, Classon M, Di Gioacchino A, Greenbaum B, De Carvalho DD. Hosseini A, et al. Among authors: di gioacchino a. Cell Rep. 2024 Feb 27;43(2):113684. doi: 10.1016/j.celrep.2024.113684. Epub 2024 Jan 22. Cell Rep. 2024. PMID: 38261511 Free PMC article.
Cancer cells co-evolve with retrotransposons to mitigate viral mimicry.
Sun S, Hong J, You E, Tsanov KM, Chacon-Barahona J, Gioacchino AD, Hoyos D, Li H, Jiang H, Ly H, Marhon S, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD. Sun S, et al. Among authors: gioacchino ad. bioRxiv [Preprint]. 2023 May 20:2023.05.19.541456. doi: 10.1101/2023.05.19.541456. bioRxiv. 2023. PMID: 37292765 Free PMC article. Preprint.
Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms.
Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov KM, Mattagajasingh O, Di Gioacchino A, Marhon SA, Chacon-Barahona J, Li H, Jiang H, Hozeifi S, Rosas-Bringas O, Xu KH, Song Y, Lang ER, Rojas AS, Nieman LT, Patel BK, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, Zenklusen D, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD. Sun S, et al. Among authors: di gioacchino a. Immunity. 2024 Dec 10;57(12):2879-2894.e11. doi: 10.1016/j.immuni.2024.10.015. Epub 2024 Nov 21. Immunity. 2024. PMID: 39577413 Free article.
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