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30 results

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Page 1
Haploidentical and Matched Sibling Donor Hematopoietic Cell Transplantation for Patients with HLA-Homozygous Haplotypes.
Kanda J, Ikegame K, Fuji S, Kurokawa M, Kanamori H, Fukuda T, Ohashi K, Ishikawa J, Ogawa H, Inoue M, Ichinohe T, Atsuta Y, Kanda Y; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Kanda J, et al. Biol Blood Marrow Transplant. 2016 Nov;22(11):2031-2037. doi: 10.1016/j.bbmt.2016.07.020. Epub 2016 Aug 1. Biol Blood Marrow Transplant. 2016. PMID: 27492794 Free article.
More than 1% of the Japanese population has HLA-homozygous haplotypes. For patients with such haplotypes, HLA-haploidentical family members who have no HLA mismatch in the graft-versus-host direction are readily available donor candidates for hematopoietic ce …
More than 1% of the Japanese population has HLA-homozygous haplotypes. For patients with such haplotypes, HLA-haploidentical f …
Impact of HLA mismatch direction on the outcome of unrelated bone marrow transplantation: a retrospective analysis from the Japan Society for Hematopoietic Cell Transplantation.
Kanda J, Ichinohe T, Fuji S, Maeda Y, Ohashi K, Fukuda T, Miyamura K, Iwato K, Eto T, Nakamae H, Kobayashi N, Mori T, Mori S, Morishima Y, Atsuta Y, Kanda Y; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Kanda J, et al. Biol Blood Marrow Transplant. 2015 Feb;21(2):305-11. doi: 10.1016/j.bbmt.2014.10.015. Epub 2014 Oct 18. Biol Blood Marrow Transplant. 2015. PMID: 25464119 Free article.
We analyzed adult patients with leukemia or myelodysplastic syndrome who received a first allogeneic stem cell transplant from an HLA-A, -B, -C, and -DRB1 matched or 1-allele mismatched unrelated donor in Japan. The effects of 1MM-Bi (n = 1020), 1MM-GVH (n = 83), and 1MM-H …
We analyzed adult patients with leukemia or myelodysplastic syndrome who received a first allogeneic stem cell transplant from an HLA
A retrospective analysis of haplo-identical HLA-mismatch hematopoietic transplantation without posttransplantation cyclophosphamide for GVHD prophylaxis in patients with adult T-cell leukemia-lymphoma.
Yoshimitsu M, Utsunomiya A, Fuji S, Fujiwara H, Fukuda T, Ogawa H, Takatsuka Y, Ishitsuka K, Yokota A, Okumura H, Ishii K, Nishikawa A, Eto T, Yonezawa A, Miyashita K, Tsukada J, Tanaka J, Atsuta Y, Kato K; ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation. Yoshimitsu M, et al. Bone Marrow Transplant. 2019 Aug;54(8):1266-1274. doi: 10.1038/s41409-018-0400-5. Epub 2018 Dec 13. Bone Marrow Transplant. 2019. PMID: 30546068
When used in conjunction with posttransplantation cyclophosphamide (PTCY) for graft-versus-host disease prophylaxis, allo-HCT from an HLA haplo-identical donor yields promising outcomes for many diseases other than ATL. However, appropriate comparisons with other donor sou …
When used in conjunction with posttransplantation cyclophosphamide (PTCY) for graft-versus-host disease prophylaxis, allo-HCT from an HLA
Impact of High-Frequency HLA Haplotypes on Clinical Cytomegalovirus Reactivation in Allogeneic Hematopoietic Stem Cell Transplantation.
Kawase T, Tanaka H, Kojima H, Uchida N, Ohashi K, Fukuda T, Ozawa Y, Ikegame K, Eto T, Mori T, Miyamoto T, Hidaka M, Shiratori S, Takanashi M, Atsuta Y, Ichinohe T, Kanda Y, Kanda J; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Kawase T, et al. Biol Blood Marrow Transplant. 2019 Dec;25(12):2482-2489. doi: 10.1016/j.bbmt.2019.07.042. Epub 2019 Aug 7. Biol Blood Marrow Transplant. 2019. PMID: 31400501 Free article. Clinical Trial.
Some studies support the hypothesis that HLA genes and haplotypes evolved by natural selection through their protective abilities against specific infectious pathogens. However, very little is known regarding the impact of high-frequency HLA haplotypes on the risk o …
Some studies support the hypothesis that HLA genes and haplotypes evolved by natural selection through their protective abilities aga …
Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation.
Yokoyama H, Kanda J, Kato S, Kondo E, Maeda Y, Saji H, Takahashi S, Onizuka M, Onishi Y, Ozawa Y, Kanamori H, Ishikawa J, Ohno Y, Ichinohe T, Takanashi M, Kato K, Atsuta Y, Kanda Y; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Yokoyama H, et al. Bone Marrow Transplant. 2019 Jul;54(7):1004-1012. doi: 10.1038/s41409-018-0369-0. Epub 2018 Nov 6. Bone Marrow Transplant. 2019. PMID: 30401965 Clinical Trial.
Although human leukocyte antigen (HLA) mismatch is often thought to be associated with a high incidence of cytomegalovirus (CMV) reactivation, it is not clear whether this process is mediated by HLA mismatch or other factors, such as acute graft-versus-host disease …
Although human leukocyte antigen (HLA) mismatch is often thought to be associated with a high incidence of cytomegalovirus (CMV) reac …
Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation.
Onizuka M, Fujii N, Nakasone H, Ogata M, Atsuta Y, Suzuki R, Uchida N, Ohashi K, Ozawa Y, Eto T, Ikegame K, Nakamae H, Inoue M, Fukuda T; Transplant Complications Working Group of the Japan Society for Hematopoietic Cell Transplantation. Onizuka M, et al. Int J Hematol. 2022 Apr;115(4):534-544. doi: 10.1007/s12185-021-03282-9. Epub 2022 Jan 28. Int J Hematol. 2022. PMID: 35088350

Multivariate analysis identified high recipient age (60 + years: HR 1.85, P = 0.003), HLA mismatch (HR 1.61, P < 0.001), female to male HSCT (HR 1.54, P < 0.001), and unrelated bone marrow transplantation (UR-BMT) (HR 3.88, P < 0.001) as significantly associated w

Multivariate analysis identified high recipient age (60 + years: HR 1.85, P = 0.003), HLA mismatch (HR 1.61, P < 0.001), female to

A single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch.
Fuji S, Kanda J, Kato S, Ikegame K, Morishima S, Miyamoto T, Hidaka M, Kubo K, Miyamura K, Tsudo M, Kobayashi H, Maesako Y, Eto T, Adachi S, Ichinohe T, Atsuta Y, Kanda Y; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Fuji S, et al. Am J Hematol. 2015 Jul;90(7):618-23. doi: 10.1002/ajh.24028. Am J Hematol. 2015. PMID: 25850370 Free article.
The relative importance of the resolution level of HLA typing has not been fully defined for related donor transplantation. To address this question, we retrospectively evaluated patients who underwent a first related hematopoietic stem cell transplantation (HSCT) from 200 …
The relative importance of the resolution level of HLA typing has not been fully defined for related donor transplantation. To addres …
Clinical significance of low-dose total body irradiation in HLA-mismatched reduced-intensity stem cell transplantation.
Fujiwara SI, Kanda J, Tatara R, Ogawa H, Fukuda T, Okumura H, Ohashi K, Iwato K, Ueda Y, Ishiyama K, Eto T, Matsuoka KI, Nakamae H, Onizuka M, Atsuta Y, Kanda Y; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Fujiwara SI, et al. Bone Marrow Transplant. 2019 Aug;54(8):1327-1336. doi: 10.1038/s41409-019-0434-3. Epub 2019 Jan 22. Bone Marrow Transplant. 2019. PMID: 30670824
The significance of low-dose total body irradiation (TBI) in HLA-mismatched reduced-intensity conditioning stem cell transplantation (RICT) remains unknown. ...These findings suggest that low-dose TBI may be beneficial for patients at high risk for relapse in HLA-mi …
The significance of low-dose total body irradiation (TBI) in HLA-mismatched reduced-intensity conditioning stem cell transplantation …
Different effects of thymoglobulin on acute leukemia with pre-transplant residual blasts in HLA mismatch transplantation.
Wakamatsu M, Murata M, Kanda J, Fukushima K, Fukuda T, Najima Y, Katayama Y, Ozawa Y, Tanaka M, Kanda Y, Eto T, Takada S, Kako S, Uchida N, Kawakita T, Yoshiko H, Ichinohe T, Atsuta Y, Terakura S; GVHD Working Group of the Japan Society for Hematopoietic Cell Transplantation. Wakamatsu M, et al. Int J Hematol. 2023 Jun;117(6):889-899. doi: 10.1007/s12185-023-03563-5. Epub 2023 Feb 22. Int J Hematol. 2023. PMID: 36814041
Here, we evaluated the impact of ATG on transplant outcomes in acute leukemia patients with PRB (n = 994) who underwent HSCT from HLA 1-allele mismatched unrelated donors (MMUD) or HLA 1-antigen mismatched related donors (MMRD). ...
Here, we evaluated the impact of ATG on transplant outcomes in acute leukemia patients with PRB (n = 994) who underwent HSCT from HLA
Human leukocyte antigen (HLA) haplotype matching in unrelated single HLA allele mismatch bone marrow transplantation.
Kawajiri A, Kawase T, Tanaka H, Fukuda T, Mukae J, Ozawa Y, Eto T, Uchida N, Mori T, Ashida T, Kondo T, Onizuka M, Ichinohe T, Atsuta Y, Morishima S, Kanda J; HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Kawajiri A, et al. Bone Marrow Transplant. 2022 Mar;57(3):407-415. doi: 10.1038/s41409-021-01552-y. Epub 2022 Jan 21. Bone Marrow Transplant. 2022. PMID: 35058581
Here, we imputed the HLA haplotypes of 3657 patients who received unrelated single HLA allele-mismatched allo-BMT, included from the Transplant Registry Unified Management Program (TRUMP) database, the Japanese registry program for hematopoietic transplantation, usi …
Here, we imputed the HLA haplotypes of 3657 patients who received unrelated single HLA allele-mismatched allo-BMT, included fr …
30 results