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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1845 1
1907 1
1926 1
1938 2
1939 1
1941 1
1942 2
1943 2
1944 1
1946 5
1947 1
1948 2
1949 4
1950 6
1951 4
1952 4
1953 6
1954 12
1955 8
1956 5
1957 2
1958 6
1959 3
1960 4
1961 3
1962 2
1964 5
1965 6
1966 5
1967 3
1968 4
1969 2
1970 2
1971 8
1972 3
1973 7
1974 4
1975 5
1976 2
1978 6
1979 12
1980 7
1981 4
1982 3
1983 3
1984 2
1985 8
1986 11
1987 5
1988 10
1989 3
1990 1
1991 13
1992 6
1993 10
1994 11
1995 14
1996 8
1997 7
1998 10
1999 5
2000 11
2001 12
2002 10
2003 17
2004 19
2005 14
2006 20
2007 30
2008 28
2009 30
2010 25
2011 36
2012 41
2013 33
2014 40
2015 38
2016 26
2017 29
2018 28
2019 34
2020 36
2021 37
2022 48
2023 38
2024 34
2025 1

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935 results

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Page 1
Relating protein pharmacology by ligand chemistry.
Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Keiser MJ, et al. Among authors: irwin jj. Nat Biotechnol. 2007 Feb;25(2):197-206. doi: 10.1038/nbt1284. Nat Biotechnol. 2007. PMID: 17287757
Ultra-large library docking for discovering new chemotypes.
Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ. Lyu J, et al. Among authors: irwin jj. Nature. 2019 Feb;566(7743):224-229. doi: 10.1038/s41586-019-0917-9. Epub 2019 Feb 6. Nature. 2019. PMID: 30728502 Free PMC article.
Structure-based discovery of CFTR potentiators and inhibitors.
Liu F, Kaplan AL, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage NS, Kondratov IS, Moroz YS, Pietz HL, Irwin JJ, Gmeiner P, Shoichet BK, Chen J. Liu F, et al. Among authors: irwin jj. Cell. 2024 Jul 11;187(14):3712-3725.e34. doi: 10.1016/j.cell.2024.04.046. Epub 2024 May 28. Cell. 2024. PMID: 38810646 Free PMC article.
Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.
Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P. Fink EA, et al. Among authors: irwin jj. Science. 2022 Sep 30;377(6614):eabn7065. doi: 10.1126/science.abn7065. Epub 2022 Sep 30. Science. 2022. PMID: 36173843 Free PMC article.
Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.
Kaplan AL, Confair DN, Kim K, Barros-Álvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA. Kaplan AL, et al. Among authors: irwin jj. Nature. 2022 Oct;610(7932):582-591. doi: 10.1038/s41586-022-05258-z. Epub 2022 Sep 28. Nature. 2022. PMID: 36171289 Free PMC article.
Brassica oleracea.
Sparrow PA, Dale PJ, Irwin JA. Sparrow PA, et al. Among authors: irwin ja. Methods Mol Biol. 2006;343:417-26. doi: 10.1385/1-59745-130-4:417. Methods Mol Biol. 2006. PMID: 16988364 Review.
Docking for EP4R antagonists active against inflammatory pain.
Gahbauer S, DeLeon C, Braz JM, Craik V, Kang HJ, Wan X, Huang XP, Billesbølle CB, Liu Y, Che T, Deshpande I, Jewell M, Fink EA, Kondratov IS, Moroz YS, Irwin JJ, Basbaum AI, Roth BL, Shoichet BK. Gahbauer S, et al. Among authors: irwin jj. Nat Commun. 2023 Dec 6;14(1):8067. doi: 10.1038/s41467-023-43506-6. Nat Commun. 2023. PMID: 38057319 Free PMC article.
Anemia in children.
Irwin JJ, Kirchner JT. Irwin JJ, et al. Am Fam Physician. 2001 Oct 15;64(8):1379-86. Am Fam Physician. 2001. PMID: 11681780 Free article. Review.
AlphaFold2 structures template ligand discovery.
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL. Lyu J, et al. Among authors: irwin jj. bioRxiv [Preprint]. 2024 Mar 13:2023.12.20.572662. doi: 10.1101/2023.12.20.572662. bioRxiv. 2024. Update in: Science. 2024 Jun 21;384(6702):eadn6354. doi: 10.1126/science.adn6354 PMID: 38187536 Free PMC article. Updated. Preprint.
Editorial: Allostatic Load and Inflammatory Bowel Disease.
Mendoza J, Irwin J. Mendoza J, et al. Among authors: irwin j. Aliment Pharmacol Ther. 2025 Jan;61(1):188-189. doi: 10.1111/apt.18325. Epub 2024 Nov 27. Aliment Pharmacol Ther. 2025. PMID: 39601634 No abstract available.
935 results