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Page 1
Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes.
Brannan KW, Chaim IA, Marina RJ, Yee BA, Kofman ER, Lorenz DA, Jagannatha P, Dong KD, Madrigal AA, Underwood JG, Yeo GW. Brannan KW, et al. Among authors: madrigal aa. Nat Methods. 2021 May;18(5):507-519. doi: 10.1038/s41592-021-01128-0. Epub 2021 May 7. Nat Methods. 2021. PMID: 33963355 Free PMC article.
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Einstein JM, Perelis M, Chaim IA, Meena JK, Nussbacher JK, Tankka AT, Yee BA, Li H, Madrigal AA, Neill NJ, Shankar A, Tyagi S, Westbrook TF, Yeo GW. Einstein JM, et al. Among authors: madrigal aa. Mol Cell. 2021 Aug 5;81(15):3048-3064.e9. doi: 10.1016/j.molcel.2021.06.014. Epub 2021 Jul 2. Mol Cell. 2021. PMID: 34216543 Free PMC article.
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment.
Trujillo CA, Rice ES, Schaefer NK, Chaim IA, Wheeler EC, Madrigal AA, Buchanan J, Preissl S, Wang A, Negraes PD, Szeto RA, Herai RH, Huseynov A, Ferraz MSA, Borges FS, Kihara AH, Byrne A, Marin M, Vollmers C, Brooks AN, Lautz JD, Semendeferi K, Shapiro B, Yeo GW, Smith SEP, Green RE, Muotri AR. Trujillo CA, et al. Among authors: madrigal aa. Science. 2021 Feb 12;371(6530):eaax2537. doi: 10.1126/science.aax2537. Science. 2021. PMID: 33574182 Free PMC article.
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.
Al-Azzam N, To JH, Gautam V, Street LA, Nguyen CB, Naritomi JT, Lam DC, Madrigal AA, Lee B, Jin W, Avina A, Mizrahi O, Mueller JR, Ford W, Schiavon CR, Rebollo E, Vu AQ, Blue SM, Madakamutil YL, Manor U, Rothstein JD, Coyne AN, Jovanovic M, Yeo GW. Al-Azzam N, et al. Among authors: madrigal aa. Neuron. 2024 Dec 18;112(24):4033-4047.e8. doi: 10.1016/j.neuron.2024.10.007. Epub 2024 Oct 31. Neuron. 2024. PMID: 39486415 Free article.
Crosstalk between CRISPR-Cas9 and the human transcriptome.
Smargon AA, Madrigal AA, Yee BA, Dong KD, Mueller JR, Yeo GW. Smargon AA, et al. Among authors: madrigal aa. Nat Commun. 2022 Mar 2;13(1):1125. doi: 10.1038/s41467-022-28719-5. Nat Commun. 2022. PMID: 35236841 Free PMC article.
Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS.
Krach F, Batra R, Wheeler EC, Vu AQ, Wang R, Hutt K, Rabin SJ, Baughn MW, Libby RT, Diaz-Garcia S, Stauffer J, Pirie E, Saberi S, Rodriguez M, Madrigal AA, Kohl Z, Winner B, Yeo GW, Ravits J. Krach F, et al. Among authors: madrigal aa. Acta Neuropathol. 2018 Sep;136(3):405-423. doi: 10.1007/s00401-018-1870-7. Epub 2018 Jun 7. Acta Neuropathol. 2018. PMID: 29881994 Free PMC article.
Tachypnea in response to hypoxemia decreases with age in older patients.
Cuerpo S, Aguiló S, Alquézar-Arbé A, Fernández C, Burillo G, Jacob J, Montero-Pérez FJ, García-Lamberechts EJ, Piñera P, Blázquez BE, de la Iglesia CG, Quesada SF, Vaswani-Bulchand A, Rodríguez-Cabrera M, Aragüés PL, Díaz-Guerra MLP, González FXA, Alcaraz AP, Collado JM, Torres GJ, Fuentes L, Martos RM, López AR, Hernández RJG, García JP, Trian EM, Del Castillo JG, Miró Ò; members of the SIESTA network. Cuerpo S, et al. Geriatr Gerontol Int. 2024 Nov;24(11):1120-1129. doi: 10.1111/ggi.14965. Epub 2024 Oct 8. Geriatr Gerontol Int. 2024. PMID: 39380254