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Analysis of brain edema in RHAPSODY.
Schleicher RL, Vorasayan P, McCabe ME, Bevers MB, Davis TP, Griffin JH, Hinduja A, Jadhav AP, Lee JM, Sawyer RN Jr, Zlokovic BV, Sheth KN, Fedler JK, Lyden P, Kimberly WT; NN104 Investigators. Schleicher RL, et al. Int J Stroke. 2024 Jan;19(1):68-75. doi: 10.1177/17474930231187268. Epub 2023 Jul 16. Int J Stroke. 2024. PMID: 37382409
Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke.
Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN Jr, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV; NeuroNEXT Clinical Trials Network NN104 Investigators. Lyden P, et al. Ann Neurol. 2019 Jan;85(1):125-136. doi: 10.1002/ana.25383. Epub 2019 Jan 7. Ann Neurol. 2019. PMID: 30450637 Free PMC article. Clinical Trial.