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Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia.
Habets P, Marcelis M, Gronenschild E, Drukker M, van Os J; Genetic Risk and Outcome of Psychosis (G.R.O.U.P). Habets P, et al. Biol Psychiatry. 2011 Mar 1;69(5):487-94. doi: 10.1016/j.biopsych.2010.08.010. Epub 2010 Oct 16. Biol Psychiatry. 2011. PMID: 20951979
METHODS: T1-weighted MRI scans were acquired from 88 patients with schizophrenia, 98 healthy siblings at higher than average genetic risk for schizophrenia, and 87 control subjects. Freesurfer software was used to measure cortical thickness for 68 brain regions. ...CONCLUS …
METHODS: T1-weighted MRI scans were acquired from 88 patients with schizophrenia, 98 healthy siblings at higher than average genetic …
Microstructural white matter network-connectivity in individuals with psychotic disorder, unaffected siblings and controls.
Michielse S, Rakijo K, Peeters S, Viechtbauer W, van Os J, Marcelis M; for Genetic Risk and Outcome of Psychosis (G.R.O.U.P.). Michielse S, et al. Neuroimage Clin. 2019;23:101931. doi: 10.1016/j.nicl.2019.101931. Epub 2019 Jul 11. Neuroimage Clin. 2019. PMID: 31491817 Free PMC article.
BACKGROUND: Altered structural network-connectivity has been reported in psychotic disorder but whether these alterations are associated with genetic vulnerability, and/or with phenotypic variation, has been less well examined. This study examined i) whether differences in …
BACKGROUND: Altered structural network-connectivity has been reported in psychotic disorder but whether these alterations are associated wit …
Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity.
Peeters SC, Gronenschild EH, van Amelsvoort T, van Os J, Marcelis M; Genetic Risk and Outcome of Psychosis (G.R.O.U.P.); Kahn R, Wiersma D, Bruggeman R, Cahn W, de Haan L, Meijer C, Myin-Germeys I. Peeters SC, et al. Brain Behav. 2016 Jun 29;6(9):e00508. doi: 10.1002/brb3.508. eCollection 2016 Sep. Brain Behav. 2016. PMID: 27688938 Free PMC article.
This study examined graph theoretical changes in relation to differential genetic risk for the disorder and aimed to identify clinical correlates. METHODS: Anatomical and resting-state MRI brain scans were obtained from 73 patients with psychotic disorder, 83 unaffected si …
This study examined graph theoretical changes in relation to differential genetic risk for the disorder and aimed to identify clinica …
Childhood trauma- and cannabis-associated microstructural white matter changes in patients with psychotic disorder: a longitudinal family-based diffusion imaging study.
Domen P, Michielse S, Peeters S, Viechtbauer W, van Os J, Marcelis M; for Genetic Risk and Outcome of Psychosis (G.R.O.U.P.). Domen P, et al. Psychol Med. 2019 Mar;49(4):628-638. doi: 10.1017/S0033291718001320. Epub 2018 May 29. Psychol Med. 2019. PMID: 29807550
CONCLUSIONS: Higher levels of cannabis or childhood trauma may compromise connectivity over the course of the illness in patients, but not in individuals at low or higher than average genetic risk for psychotic disorder, suggesting interactions between the environment and …
CONCLUSIONS: Higher levels of cannabis or childhood trauma may compromise connectivity over the course of the illness in patients, but not i …