The ubiquitin proteolytic system plays an important role in a broad array of basic cellular
processes. Among these are regulation of cell cycle, modulation of the immune and …

Myc proteins regulate cell growth and division and are implicated in a wide range of human
cancers. We show here that Fbw7, a component of the SCF Fbw7 ubiquitin ligase and a …

The Myc/Max/Mad transcription factor network is critically involved in cell behavior; however,
there is relatively little information on its genomic binding sites. We have employed the …

Processing of the p105 precursor to form the active subunit p50 of the NF‐κB transcription
factor is a unique case in which the ubiquitin system is involved in limited processing rather …

The nuclear translocation of NF-kappa B follows the degradation of its inhibitor, I kappa B
alpha, an event coupled with stimulation-dependent inhibitor phosphorylation. Prevention of …

Proteolysis via the ubiquitin system plays important roles in a variety of basic cellular processes.
Among these are regulation of cell cycle and division, modulation of the immune and …

Histone deacetylases (HDACs) are thought to function as critical mediators of transcriptional
repression. However, the physiological targets and posttranslational modifications of the …

The human tumor suppressor Fbw7/hCdc4 functions as a phosphoepitope-specific substrate
recognition component of SCF ubiquitin ligases [1] that catalyzes the ubiquitination of cyclin …

Regulating ribosome number is thought to control cellular growth 1 . Synthesis of ribosomal
RNA (rRNA) is a limiting step in ribosome biogenesis and rates of rRNA synthesis are …

Nuclear oncoproteins are among the most rapidly degraded intracellular proteins. Previous
work has implicated the ubiquitin-mediated proteolytic system in the turnover of short-lived …