Background The regulatory mechanisms underlying tissue specificity are a crucial part of
the development and maintenance of multicellular organisms. A genome-wide analysis of …

Introduction Pregestational and gestational diabetes mellitus (PGDM; GDM) are significant
health concerns because they are associated with an increased rate of malformations and …

A study was conducted to analyze the role of the homeobox (Hox) gene in the evolution of
metazoans and its relevance in establishing phyletic affinities. The genes were divided into …

Antennapedia-class vertebrate homeobox genes have been classified with regard to their
chromosomal locations and nucleotide sequence similarities within the 183-base-pair …

Background Maternal diabetes is a well-known risk factor for birth defects, such as heart
defects and neural tube defects. The causative molecular mechanisms in the developing …

BACKGROUND: Maternal diabetes during pregnancy is a well‐known teratogen that increases
the risk for birth defects, such as neural tube defects (NTDs). We have previously shown …

Using transgenic embryos, we have identified two distinct CNS progenitor cell-specific
enhancers, each requiring the cooperation of at least two independent regulatory sites, within the …

Homeobox genes of the Hox class are required for proper patterning of skeletal elements,
but how they regulate the differentiation of specific tissues is unclear. We show here that …

Hox genes encode transcription factors that are required for proper development of certain
tissues and for patterning of the hindbrain, the limbs, and skeleton. They are also expressed …

Dietary micronutrient composition has long been recognized as a determiningfactor for human
health. Historically, biochemical research has successfully unraveled how vitamins serve …