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Edward L. D'Antonio

Prof. Dr. Edward L. D'Antonio

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My training is in Chemistry and I received my Ph.D. at North Carolina State University in 2010. From 2010-2013, I was a postdoctoral fellow at the University of Pennsylvania where I was trained in structural biology and medicinal chemistry. Since 2013, the goal of my research program has been to identify chemical compounds that inhibit protein targets of pathogenic microorganisms. The drug discovery strategies that I employ include structure-based drug design, hit-to-lead expansions, structure-activity relationships, and high-throughput screening. Compounds are further developed by experimentally searching for higher efficacy and lower toxicity than clinically used drugs for the treatment of neglected tropical diseases.

Research Keywords & Expertise

Neglected Tropical Dis...
Medicinal Chemistry & ... 1
Structural Biology and...

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Neglected Tropical Diseases

Short Biography

My training is in Chemistry and I received my Ph.D. at North Carolina State University in 2010. From 2010-2013, I was a postdoctoral fellow at the University of Pennsylvania where I was trained in structural biology and medicinal chemistry. Since 2013, the goal of my research program has been to identify chemical compounds that inhibit protein targets of pathogenic microorganisms. The drug discovery strategies that I employ include structure-based drug design, hit-to-lead expansions, structure-activity relationships, and high-throughput screening. Compounds are further developed by experimentally searching for higher efficacy and lower toxicity than clinically used drugs for the treatment of neglected tropical diseases.

Honors and Awards

Outstanding Undergraduate Research Mentor Award (2018)

One of three awards selected throughout all campuses of the state for the University of South Carolina.

University of South Carolina


The American Institute of Chemists Foundation Award (2008)

The American Institute of Chemists Foundation


Career Timeline

University of South Carolina Beaufort

Full Professor of Biochemistry and Structural Biology

01 August 2023 - 29 September 2024


University of South Carolina Beaufort

Associate Professor of Biochemistry and Structural Biology

01 July 2018 - 01 August 2023


University of South Carolina Beaufort

Assistant Professor of Biochemistry and Structural Biology

01 July 2013 - 01 July 2018