IMGT/LIGM-DB logo
Database contains
251540 sequences
from 368 species

IMGT/LIGM-DB sequence

Version:
1.2.11
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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D86996 - Annotation

Sections
Accession number D86996
Sequence version 1
Secondary accession numbers
IMGT annotation level by annotators
Definition Homo sapiens immunoglobulin lambda gene locus DNA, clone:23F1.
Species Homo sapiens (human)
Taxonomy cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens
Sequence length 39090
IMGT/LIGM-DB dates 27-MAY-1997
  15-JUN-2024 (v. 21)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type gDNA
Configuration type germline
Gene type variable
Molecule entity type V-gene
Functionality type pseudogene, functional, ORF
Chain type IG-Light, IG-Light-Lambda-IGL
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), immunoglobulin (IG), promoter, IMGT reference sequence

CLASSIFICATION

IMGT Groups IGLV
IMGT Subgroups IGLV6, IGLV10, IGLV11, IGLV(IV)

DESCRIPTION

V-CLUSTER   1..39090
  cell_type human/rodent somatic cell hybrid
  chromosome 22
  clone 23F1
  clone_lib specific cosmid library; LL22NC03
  db_xref taxon:9606
  IMGT_map 22q11.2
  note IGLV6-57(V1-22), IGLV(I)-56(V1-21P), IGLV11-55(V4-6), IGLV10-54(V1-20), IGLV(IV)-53(V4-5P)
  organism Homo sapiens
  sequenced_mol DNA
V-GENE   1..11052
  IMGT_allele IGLV6-57*01
  IMGT_gene IGLV6-57
  note functional
5'UTR   1..9350
OCTAMER   9244..9251
TATA_BOX   9284..9289
L-INTRON-L   9351..9532
L-PART1   9351..9396
atggcctgggctccactacttctcaccctcctcgctcactgcacag M A W A P L L L T L L A H C T
W P G L H Y F S P S S L T A Q
G L G S T T S H P P R S L H
INIT-CODON   9351..9353
DONOR-SPLICE   9396..9398
V-INTRON   9397..9521
ACCEPTOR-SPLICE   9519..9523
V-EXON   9522..9828
gttcttgggccaattttatgctgactcagccccactctgtgtcggagtctccggggaagacggtaaccatctcctgcacccgcagcagtggcagcattgccagcaactatgtgcagtggtaccagcagcgcccgggcagttcccccaccactgtgatctatgaggataaccaaagaccctctggggtccctgatcggttctctggctccatcgacagctcctccaactctgcctccctcaccatctctggactgaagactgaggacgaggctgactactactgtcagtcttatgatagcagcaatca V L G P I L C * L S P T L C R S L R G R R * P S P A P A A V A A L P A T M C S G T S S A R A V P P P L * S M R I T K D P L G S L I G S L A P S T A P P T L P P S P S L D * R L R T R L T T T V S L M I A A I
F L G Q F Y A D S A P L C V G V S G E D G N H L L H P Q Q W Q H C Q Q L C A V V P A A P G Q F P H H C D L * G * P K T L W G P * S V L W L H R Q L L Q L C L P H H L W T E D * G R G * L L L S V L * * Q Q S
S W A N F M L T Q P H S V S E S P G K T V T I S C T R S S G S I A S N Y V Q W Y Q Q R P G S S P T T V I Y E D N Q R P S G V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C Q S Y D S S N
L-PART2   9522..9532
gttcttgggcc V L G
F L G
S W A
V-REGION   9533..9828
  CDR_length [8.3.7]
  db_xref InterPro:IPR003596
  db_xref InterPro:IPR003599
  db_xref InterPro:IPR007110
  db_xref UniProt/TrEMBL:Q5NV88
  FR_length [25.17.38.G]
  IMGT_allele IGLV6-57*01
  IMGT_gene IGLV6-57
  note similar to Z73673
  protein_id BAA19991.1
aattttatgctgactcagccccactctgtgtcggagtctccggggaagacggtaaccatctcctgcacccgcagcagtggcagcattgccagcaactatgtgcagtggtaccagcagcgcccgggcagttcccccaccactgtgatctatgaggataaccaaagaccctctggggtccctgatcggttctctggctccatcgacagctcctccaactctgcctccctcaccatctctggactgaagactgaggacgaggctgactactactgtcagtcttatgatagcagcaatca N F M L T Q P H S V S E S P G K T V T I S C T R S S G S I A S N Y V Q W Y Q Q R P G S S P T T V I Y E D N Q R P S G V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C Q S Y D S S N
I L C * L S P T L C R S L R G R R * P S P A P A A V A A L P A T M C S G T S S A R A V P P P L * S M R I T K D P L G S L I G S L A P S T A P P T L P P S P S L D * R L R T R L T T T V S L M I A A I
F Y A D S A P L C V G V S G E D G N H L L H P Q Q W Q H C Q Q L C A V V P A A P G Q F P H H C D L * G * P K T L W G P * S V L W L H R Q L L Q L C L P H H L W T E D * G R G * L L L S V L * * Q Q S
FR1-IMGT   9533..9607
  AA_IMGT AA 1 to 26, AA 10 is missing
aattttatgctgactcagccccactctgtgtcggagtctccggggaagacggtaaccatctcctgcacccgcagc N F M L T Q P H S V S E S P G K T V T I S C T R S
I L C * L S P T L C R S L R G R R * P S P A P A
F Y A D S A P L C V G V S G E D G N H L L H P Q
1st-CYS   9596..9598
CDR1-IMGT   9608..9631
  AA_IMGT AA 27 to 38, AA 31, 32, 33 and 34 are missing
agtggcagcattgccagcaactat S G S I A S N Y
V A A L P A T
W Q H C Q Q L
FR2-IMGT   9632..9682
  AA_IMGT AA 39 to 55
gtgcagtggtaccagcagcgcccgggcagttcccccaccactgtgatctat V Q W Y Q Q R P G S S P T T V I Y
C S G T S S A R A V P P P L * S
A V V P A A P G Q F P H H C D L
CONSERVED-TRP   9638..9640
CDR2-IMGT   9683..9691
  AA_IMGT AA 56 to 65, AA 58, 59, 60, 61, 62, 63 and 64 are missing
gaggataac E D N
R I
G *
FR3-IMGT   9692..9805
  AA_IMGT AA 66 to 104, AA 73 is missing
caaagaccctctggggtccctgatcggttctctggctccatcgacagctcctccaactctgcctccctcaccatctctggactgaagactgaggacgaggctgactactactgt Q R P S G V P D R F S G S I D S S S N S A S L T I S G L K T E D E A D Y Y C
K D P L G S L I G S L A P S T A P P T L P P S P S L D * R L R T R L T T T
K T L W G P * S V L W L H R Q L L Q L C L P H H L W T E D * G R G * L L L
2nd-CYS   9803..9805
CDR3-IMGT   9806..9828
  AA_IMGT AA 105 to 111
cagtcttatgatagcagcaatca Q S Y D S S N
S L M I A A I
V L * * Q Q S
3'UTR   9829..11052
V-RS   9829..9867
V-HEPTAMER   9829..9835
V-SPACER   9836..9858
V-NONAMER   9859..9867
V-GENE   11053..12573
  IMGT_allele IGLV(I)-56*01
  IMGT_gene IGLV(I)-56
  note stop codon, frameshift
  pseudo frameshift in V-REGION: several insertions and deletions
5'UTR   11053..12275
V-REGION   12276..12571
  IMGT_allele IGLV(I)-56*01
  IMGT_gene IGLV(I)-56
  note 63,7% of similarity with IGLV10-67 gene
tccacatggcactgacagcctctttcactgaccaagcctccgggactgacaattacaatcacccaccctggaaacagccataatactgtcaatcaaggcacagcttggattcaggagcacctgggacatgtccccaaacctcagacccagagggggtaacaaccatccctcagggacctcagggaatttcccagccccatgttaggcagtttggcctccctggccatctctgggctccaggctggcgacggtgctgattttcactatttagcacagaatggcagcctcgctgatta S T W H * Q P L S L T K P P G L T I T I T H P G N S H N T V N Q G T A W I Q E H L G H V P K P Q T Q R G * Q P S L R D L R E F P S P M L G S L A S L A I S G L Q A G D G A D F H Y L A Q N G S L A D
P H G T D S L F H * P S L R D * Q L Q S P T L E T A I I L S I K A Q L G F R S T W D M S P N L R P R G G N N H P S G T S G N F P A P C * A V W P P W P S L G S R L A T V L I F T I * H R M A A S L I
H M A L T A S F T D Q A S G T D N Y N H P P W K Q P * Y C Q S R H S L D S G A P G T C P Q T S D P E G V T T I P Q G P Q G I S Q P H V R Q F G L P G H L W A P G W R R C * F S L F S T E W Q P R * L
3'UTR   12572..12573
V-GENE   12574..13896
  IMGT_allele IGLV(IV)-55-1*01
  IMGT_gene IGLV(IV)-55-1
  pseudo No L-PART1, frameshift in V-REGION: several insertions and deletions, no V-NONAMER
5'UTR   12574..12575
V-REGION   12576..12876
  IMGT_allele IGLV(IV)-55-1*01
  IMGT_gene IGLV(IV)-55-1
  pseudo No L-PART1, frameshift in V-REGION: several insertions and deletions, no V-NONAMER
ctgattatctggatgctctgtgactccttctgtgcatctctgggatcatcattcagactcacctgcaccctgagcagtaacatcaatgttgtttgctatgacatttactggaaacatgacagggcagggagccttccctccctggtatctactgagattctactgagattcaagcagaaccagggctcagggtccccagcctcttctccgtgtgagtgggtgccgtcgccagtgctgaggctttccatatctttggtctcaagcttgaggatgaggctactcatggcacagtagtgcctct L I I W M L C D S F C A S L G S S F R L T C T L S S N I N V V C Y D I Y W K H D R A G S L P S L V S T E I L L R F K Q N Q G S G S P A S S P C E W V P S P V L R L S I S L V S S L R M R L L M A Q * C L
* L S G C S V T P S V H L W D H H S D S P A P * A V T S M L F A M T F T G N M T G Q G A F P P W Y L L R F Y * D S S R T R A Q G P Q P L L R V S G C R R Q C * G F P Y L W S Q A * G * G Y S W H S S A S
D Y L D A L * L L L C I S G I I I Q T H L H P E Q * H Q C C L L * H L L E T * Q G R E P S L P G I Y * D S T E I Q A E P G L R V P S L F S V * V G A V A S A E A F H I F G L K L E D E A T H G T V V P
3'UTR   12877..13896
V-HEPTAMER   12877..12883
V-GENE   13897..22028
  IMGT_allele IGLV11-55*01
  IMGT_gene IGLV11-55
  note ORF
5'UTR   13897..15220
OCTAMER   15115..15122
TATA_BOX   15158..15163
L-INTRON-L   15221..15395
L-PART1   15221..15266
atggccctgactcctctcctcctcctgctcctctctcactgcacag M A L T P L L L L L L S H C T
W P * L L S S S C S S L T A Q
G P D S S P P P A P L S L H
INIT-CODON   15221..15223
DONOR-SPLICE   15266..15268
V-INTRON   15267..15384
ACCEPTOR-SPLICE   15382..15386
V-EXON   15385..15707
gttccctctcccggcccgtgctgactcagccgccctctctgtctgcatccccgggagcaacagccagactcccctgcaccctgagcagtgacctcagtgttggtggtaaaaacatgttctggtaccagcagaagccagggagctctcccaggttattcctgtatcactactcagactcagacaagcagctgggacctggggtccccagtcgagtctctggctccaaggagacctcaagtaacacagcgtttttgctcatctctgggctccagcctgaggacgaggccgattattactgccaggtgtacgaaagtagtgctaat V P S P G P C * L S R P L C L H P R E Q Q P D S P A P * A V T S V L V V K T C S G T S R S Q G A L P G Y S C I T T Q T Q T S S W D L G S P V E S L A P R R P Q V T Q R F C S S L G S S L R T R P I I T A R C T K V V L
F P L P A R A D S A A L S V C I P G S N S Q T P L H P E Q * P Q C W W * K H V L V P A E A R E L S Q V I P V S L L R L R Q A A G T W G P Q S S L W L Q G D L K * H S V F A H L W A P A * G R G R L L L P G V R K * C *
S L S R P V L T Q P P S L S A S P G A T A R L P C T L S S D L S V G G K N M F W Y Q Q K P G S S P R L F L Y H Y S D S D K Q L G P G V P S R V S G S K E T S S N T A F L L I S G L Q P E D E A D Y Y C Q V Y E S S A N
L-PART2   15385..15395
gttccctctcc V P S
F P L
S L S
V-REGION   15396..15707
  CDR_length [9.7.8]
  db_xref InterPro:IPR003596
  db_xref InterPro:IPR003599
  db_xref InterPro:IPR007110
  db_xref UniProt/TrEMBL:Q5NV87
  FR_length [25.17.38.G]
  IMGT_allele IGLV11-55*01
  IMGT_gene IGLV11-55
  note 77% of similarity with IGLV5-37 gene
  protein_id BAA19992.1
cggcccgtgctgactcagccgccctctctgtctgcatccccgggagcaacagccagactcccctgcaccctgagcagtgacctcagtgttggtggtaaaaacatgttctggtaccagcagaagccagggagctctcccaggttattcctgtatcactactcagactcagacaagcagctgggacctggggtccccagtcgagtctctggctccaaggagacctcaagtaacacagcgtttttgctcatctctgggctccagcctgaggacgaggccgattattactgccaggtgtacgaaagtagtgctaat R P V L T Q P P S L S A S P G A T A R L P C T L S S D L S V G G K N M F W Y Q Q K P G S S P R L F L Y H Y S D S D K Q L G P G V P S R V S G S K E T S S N T A F L L I S G L Q P E D E A D Y Y C Q V Y E S S A N
G P C * L S R P L C L H P R E Q Q P D S P A P * A V T S V L V V K T C S G T S R S Q G A L P G Y S C I T T Q T Q T S S W D L G S P V E S L A P R R P Q V T Q R F C S S L G S S L R T R P I I T A R C T K V V L
A R A D S A A L S V C I P G S N S Q T P L H P E Q * P Q C W W * K H V L V P A E A R E L S Q V I P V S L L R L R Q A A G T W G P Q S S L W L Q G D L K * H S V F A H L W A P A * G R G R L L L P G V R K * C *
FR1-IMGT   15396..15470
  AA_IMGT AA 1 to 26, AA 10 is missing
cggcccgtgctgactcagccgccctctctgtctgcatccccgggagcaacagccagactcccctgcaccctgagc R P V L T Q P P S L S A S P G A T A R L P C T L S
G P C * L S R P L C L H P R E Q Q P D S P A P *
A R A D S A A L S V C I P G S N S Q T P L H P E
1st-CYS   15459..15461
CDR1-IMGT   15471..15497
  AA_IMGT AA 27 to 38, AA 32, 33 and 34 are missing
agtgacctcagtgttggtggtaaaaac S D L S V G G K N
V T S V L V V K
* P Q C W W * K
FR2-IMGT   15498..15548
  AA_IMGT AA 39 to 55
atgttctggtaccagcagaagccagggagctctcccaggttattcctgtat M F W Y Q Q K P G S S P R L F L Y
C S G T S R S Q G A L P G Y S C
V L V P A E A R E L S Q V I P V
CONSERVED-TRP   15504..15506
CDR2-IMGT   15549..15569
  AA_IMGT AA 56 to 65, AA 60, 61 and 62 are missing
cactactcagactcagacaag H Y S D S D K
T T Q T Q T
L L R L R Q
FR3-IMGT   15570..15683
  AA_IMGT AA 66 to 104, AA 73 is missing
cagctgggacctggggtccccagtcgagtctctggctccaaggagacctcaagtaacacagcgtttttgctcatctctgggctccagcctgaggacgaggccgattattactgc Q L G P G V P S R V S G S K E T S S N T A F L L I S G L Q P E D E A D Y Y C
S W D L G S P V E S L A P R R P Q V T Q R F C S S L G S S L R T R P I I T
A G T W G P Q S S L W L Q G D L K * H S V F A H L W A P A * G R G R L L L
2nd-CYS   15681..15683
CDR3-IMGT   15684..15707
  AA_IMGT AA 105 to 112
caggtgtacgaaagtagtgctaat Q V Y E S S A N
R C T K V V L
G V R K * C *
3'UTR   15708..22028
V-RS   15708..15746
V-HEPTAMER   15708..15714
V-SPACER   15715..15737
V-NONAMER   15738..15746
V-GENE   22029..32952
  IMGT_allele IGLV10-54*02
  IMGT_gene IGLV10-54
  note functional
5'UTR   22029..28348
OCTAMER   28237..28244
TATA_BOX   28279..28284
L-INTRON-L   28349..28517
L-PART1   28349..28394
atgccctgggctctgctcctcctgaccctcctcactcactctgcag M P W A L L L L T L L T H S A
C P G L C S S * P S S L T L Q
A L G S A P P D P P H S L C
INIT-CODON   28349..28351
DONOR-SPLICE   28394..28396
V-INTRON   28395..28506
ACCEPTOR-SPLICE   28504..28508
V-EXON   28507..28813
tgtcagtggtccaggcagggctgactcagccaccctcggtgtccaagggcttgagacagaccgccacactcacctgcactgggaacagcaacattgttggcaaccaaggagcagcttggctgcagcagcaccagggccaccctcccaaactcctatcctacaggaataacaaccggccctcagggatctcagagagattctctgcatccaggtcaggaaacacagcctccctgaccattactggactccagcctgaggacgaggctgactattactgctcagcattggacagcagcctcagtgctca C Q W S R Q G * L S H P R C P R A * D R P P H S P A L G T A T L L A T K E Q L G C S S T R A T L P N S Y P T G I T T G P Q G S Q R D S L H P G Q E T Q P P * P L L D S S L R T R L T I T A Q H W T A A S V L
V S G P G R A D S A T L G V Q G L E T D R H T H L H W E Q Q H C W Q P R S S L A A A A P G P P S Q T P I L Q E * Q P A L R D L R E I L C I Q V R K H S L P D H Y W T P A * G R G * L L L L S I G Q Q P Q C S
S V V Q A G L T Q P P S V S K G L R Q T A T L T C T G N S N I V G N Q G A A W L Q Q H Q G H P P K L L S Y R N N N R P S G I S E R F S A S R S G N T A S L T I T G L Q P E D E A D Y Y C S A L D S S L S A
L-PART2   28507..28517
tgtcagtggtc C Q W
V S G
S V V
V-REGION   28518..28813
  CDR_length [8.3.9]
  db_xref REMTREMBL:BAA19993
  FR_length [25.17.36.G]
  IMGT_allele IGLV10-54*02
  IMGT_gene IGLV10-54
  note 98% of similarity with X73676
  protein_id BAA19993.1
caggcagggctgactcagccaccctcggtgtccaagggcttgagacagaccgccacactcacctgcactgggaacagcaacattgttggcaaccaaggagcagcttggctgcagcagcaccagggccaccctcccaaactcctatcctacaggaataacaaccggccctcagggatctcagagagattctctgcatccaggtcaggaaacacagcctccctgaccattactggactccagcctgaggacgaggctgactattactgctcagcattggacagcagcctcagtgctca Q A G L T Q P P S V S K G L R Q T A T L T C T G N S N I V G N Q G A A W L Q Q H Q G H P P K L L S Y R N N N R P S G I S E R F S A S R S G N T A S L T I T G L Q P E D E A D Y Y C S A L D S S L S A
R Q G * L S H P R C P R A * D R P P H S P A L G T A T L L A T K E Q L G C S S T R A T L P N S Y P T G I T T G P Q G S Q R D S L H P G Q E T Q P P * P L L D S S L R T R L T I T A Q H W T A A S V L
G R A D S A T L G V Q G L E T D R H T H L H W E Q Q H C W Q P R S S L A A A A P G P P S Q T P I L Q E * Q P A L R D L R E I L C I Q V R K H S L P D H Y W T P A * G R G * L L L L S I G Q Q P Q C S
FR1-IMGT   28518..28592
  AA_IMGT AA 1 to 26, AA 10 is missing
caggcagggctgactcagccaccctcggtgtccaagggcttgagacagaccgccacactcacctgcactgggaac Q A G L T Q P P S V S K G L R Q T A T L T C T G N
R Q G * L S H P R C P R A * D R P P H S P A L G
G R A D S A T L G V Q G L E T D R H T H L H W E
1st-CYS   28581..28583
CDR1-IMGT   28593..28616
  AA_IMGT AA 27 to 38, AA 31, 32, 33 and 34 are missing
agcaacattgttggcaaccaagga S N I V G N Q G
A T L L A T K
Q H C W Q P R
FR2-IMGT   28617..28667
  AA_IMGT AA 39 to 55
gcagcttggctgcagcagcaccagggccaccctcccaaactcctatcctac A A W L Q Q H Q G H P P K L L S Y
Q L G C S S T R A T L P N S Y P
S L A A A A P G P P S Q T P I L
CONSERVED-TRP   28623..28625
CDR2-IMGT   28668..28676
  AA_IMGT AA 56 to 65, AA 58, 59, 60, 61, 62, 63 and 64 are missing
aggaataac R N N
G I
E *
FR3-IMGT   28677..28784
  AA_IMGT AA 66 to 104, AA 73, 81 and 82 are missing
aaccggccctcagggatctcagagagattctctgcatccaggtcaggaaacacagcctccctgaccattactggactccagcctgaggacgaggctgactattactgc N R P S G I S E R F S A S R S G N T A S L T I T G L Q P E D E A D Y Y C
T G P Q G S Q R D S L H P G Q E T Q P P * P L L D S S L R T R L T I T
P A L R D L R E I L C I Q V R K H S L P D H Y W T P A * G R G * L L L
2nd-CYS   28782..28784
CDR3-IMGT   28785..28813
  AA_IMGT AA 105 to 113
tcagcattggacagcagcctcagtgctca S A L D S S L S A
Q H W T A A S V L
S I G Q Q P Q C S
3'UTR   28814..32952
V-RS   28814..28852
V-HEPTAMER   28814..28820
V-SPACER   28821..28843
V-NONAMER   28844..28852
V-GENE   32953..39090
  IMGT_allele IGLV(IV)-53*01
  IMGT_gene IGLV(IV)-53
  note frameshift
  pseudo
5'UTR   32953..33190
L-INTRON-L   33191..33364
L-PART1   33191..33233
atggcctggacccctctcgtgcttgtcctcactccctgcacat M A W T P L V L V L T P C T
W P G P L S C L S S L P A H
G L D P S R A C P H S L H
INIT-CODON   33191..33193
DONOR-SPLICE   33233..33235
V-INTRON   33234..33353
ACCEPTOR-SPLICE   33351..33355
V-EXON   33354..33677
gttccctcttccaggctgggctgacccaggtgtcctcactcccagcatcttcatgcagatcaaacactcacctgcactcagagcatatcggctttcatatcggtggcaaaaataccttcttttccctacagaatccagggagccctccaactatgttctgagattatgctcaggctaaaatgagtaccaggcctctggggtccccagacaattctctgggttgagaggctcctccagagtctcaagttatttggtcgtctctggccttcaccttgaggatggagcagatcatctctctcagatgggctgacagggcatggctta V P S S R L G * P R C P H S Q H L H A D Q T L T C T Q S I S A F I S V A K I P S F P Y R I Q G A L Q L C S E I M L R L K * V P G L W G P Q T I L W V E R L L Q S L K L F G R L W P S P * G W S R S S L S D G L T G H G L
F P L P G W A D P G V L T P S I F M Q I K H S P A L R A Y R L S Y R W Q K Y L L F P T E S R E P S N Y V L R L C S G * N E Y Q A S G V P R Q F S G L R G S S R V S S Y L V V S G L H L E D G A D H L S Q M G * Q G M A
S L F Q A G L T Q V S S L P A S S C R S N T H L H S E H I G F H I G G K N T F F S L Q N P G S P P T M F * D Y A Q A K M S T R P L G S P D N S L G * E A P P E S Q V I W S S L A F T L R M E Q I I S L R W A D R A W L
L-PART2   33354..33364
gttccctcttc V P S
F P L
S L F
V-REGION   33365..33677
  IMGT_allele IGLV(IV)-53*01
  IMGT_gene IGLV(IV)-53
  note 61,5% of similarity with IGLV5-52
caggctgggctgacccaggtgtcctcactcccagcatcttcatgcagatcaaacactcacctgcactcagagcatatcggctttcatatcggtggcaaaaataccttcttttccctacagaatccagggagccctccaactatgttctgagattatgctcaggctaaaatgagtaccaggcctctggggtccccagacaattctctgggttgagaggctcctccagagtctcaagttatttggtcgtctctggccttcaccttgaggatggagcagatcatctctctcagatgggctgacagggcatggctta Q A G L T Q V S S L P A S S C R S N T H L H S E H I G F H I G G K N T F F S L Q N P G S P P T M F * D Y A Q A K M S T R P L G S P D N S L G * E A P P E S Q V I W S S L A F T L R M E Q I I S L R W A D R A W L
R L G * P R C P H S Q H L H A D Q T L T C T Q S I S A F I S V A K I P S F P Y R I Q G A L Q L C S E I M L R L K * V P G L W G P Q T I L W V E R L L Q S L K L F G R L W P S P * G W S R S S L S D G L T G H G L
G W A D P G V L T P S I F M Q I K H S P A L R A Y R L S Y R W Q K Y L L F P T E S R E P S N Y V L R L C S G * N E Y Q A S G V P R Q F S G L R G S S R V S S Y L V V S G L H L E D G A D H L S Q M G * Q G M A
3'UTR   33678..39090
V-RS   33678..33716
V-HEPTAMER   33678..33684
V-SPACER   33685..33707
V-NONAMER   33708..33716

Literature references

[1] 1-39090
Shimizu N.

Submitted to the ENA/GenBank/DDBJ databases (08-AUG-1996)
Nobuyoshi Shimizu, Keio University School of Medicine, Department of Molecular Biology; 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan (E-mail:[email protected], Tel:03-3351-2370, Fax:03-3351-2370)
[2] -1--1
Kawasaki K., Minoshima S., Mine E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N.
One-megabase sequence analysis of the human immunoglobulin lambda gene locus
Genome Res. 7(3):250-261 (1997)
PUBMED: 9074928

Database cross-references

Database Identifiers Relation
Ensembl-Scaffolds D86996.1:1-39090, homo_sapiens
IMGT/LIGM-DB D86996
MD5 a6f7696484224e7de3f7cf528e3b9070

Sequence

Length : 39090 BP
Composition : 10972 A; 9225 C; 8966 G; 9927 T; 0 other

     gatcattcag accttggttc accttataga tcctgaatat gtcccaaagc tgtgctgtgt        60
     gccaactaaa ctcaatgcca ttttggttct ttacttcaat gacaattcca aaatcacctt       120
     gaaaaaaata cagaaatatg gttgtaagag cttgtggata ttgctaactt gaaaccagat       180
     gctggggaca cacattctgc cttggattcc ttggtcatag ctgccttaaa aaacatacag       240
     aagcacagtg gaggtggagg gataagactt tgaaaccatc tcatgctgat gccttactgc       300
     ccgagaaaaa ttttaacgga ccttgctaat aatttgctca cttggtaagt aacatgagta       360
     gttgttggtc tgtactaagc tgagtttggt tgtctggtaa ctacagaaac ttaaacttaa       420
     aaggtacccc ccaagcccac caaatttaat tttagctata gttcaagcta tttgggttat       480
     tagtgagtaa atagggaaaa taatctcaat ggagttaaat gtattcttgg gtaaagtatc       540
     agctggttta ttagtgtcta tcaaaggtac attttacaga tagtgaaagt tggggaagta       600
     ggaataactc ctctattcac agatttcatt cccaggaagg caaattttat actggatcca       660
     cagtccaggc catagcccgg gctccttggg gatgcctctg tctcagtctt tgctgttatg       720
     agtttgtgct ggagttctgt tggtgtgaaa atatacttat ttcagtcaaa acaaaccata       780
     tcattttcac atctcagtcc tccatttgct gtattctttg ctagtaccca aagtagactg       840
     attaaacttt gaagtgaggc ttagaggagt ggaaagcatt tgtgacaggc tccatggtaa       900
     ctgtgtaaca tgtgaaagca atgctgcacc tcttctttat tggaatgact ttttgaccag       960
     cacattaact tgaggactgc cgactctaat atctatttca ggaaagcggt gctttgtctt      1020
     tttactacag agcataccac gtgattgggt tagaaccaac aaaggaaata aaatgggaaa      1080
     gggtgcccca cctttaagaa tggctttagg gggatgagtg tgccatttat gaatggaaat      1140
     tatgattttc tcttgtagaa aggaaggctc agattaaatt ttagaatatt tttaaaatat      1200
     ctttttcacc aacatgtact gggaaagcaa tttcatacta aactgattaa atgatagttt      1260
     tataatctat aactgcagta atggtttttt gtaaatatga agtataattt attttatatc      1320
     tgttttgctg taacattgaa ggaaatacca gacattttct ttaagtgttt atttagaaag      1380
     taccaggaga tggttccaag atggccaaat aggaacagct ccagtctaca gctcccagcg      1440
     tgagtgacgc agaagatggg tgatttctgc atttccaact gaggtaccgg gttcatctca      1500
     ctggggcttg ttggacagtg ggtgcaggac agtgggtgca gtgcactgag tgtgagccga      1560
     agcaggatga ggcatcgcct cacctgggaa gtgcaagggg tcagggaatt ccctttccta      1620
     gccaagggaa gtggtgacag atggcacctg gaaaatcggg tcactctcac cctaatactg      1680
     cgcttttcca atggtcttag caaacggcac accaggagtt tatatcccgc acctggctca      1740
     gagggtccca cgcctacgga gcctcactca ttgctagcac agcagtctga gatcaaacta      1800
     caaggtggca gtgaggctgg gggaggggcg cccaccattg ctgaggcttg agtaggtaaa      1860
     cagagtggcc aggaagctcg aactgggtgg agcccaccac agctcgagaa ggcctgcctg      1920
     cctctgtaga ctccacctct gggggcaggg catagccaaa caaaaggcag cagaaacctc      1980
     tgcagactta aatgtccctg tctgacagct ttgaggagag tagtgattct cccagcatgt      2040
     agcttgagat ctgagaatgg acagactgcc tcaagtgggt ccctgaccca tgagtagcct      2100
     aactgggagg caccccccag taggggcaga ctgacacctc acatggccag atacccctct      2160
     gagatgaaac ttccagagga atgatcagac agcaacattt gctgttcagc aatattcgct      2220
     gttctgcagc ctccgctgct gatgcccagg caaacagggt ctggagtgga cctctggcaa      2280
     actccaacag acctgcagct gaaggtcctg actgttagaa ggaaaactaa caaacagaaa      2340
     ggacatccac accaaaaacc catctgtatg tcaccatctt caaagaccaa aggtagataa      2400
     aaccacaaag atggggaaaa aacagggcag aaaaactgaa aattctaaaa atcagagtgc      2460
     ctctcctcct ccaaaggaat gcagctcctc accagcaatg gaactaagct ggacagagga      2520
     tgactttgag gagttgagag aagaaggctt cagacaatca aacttctccg agctaaagga      2580
     ggaagtttga acccatcaca aagaagttaa aaaatcttga aaaaatatta gacaaatggc      2640
     taactagaat aaccaatgta gagaagtcct taaaggatct gaaggagctg aaaaccatgg      2700
     cacgagaact acgtgacgaa tgcacaagct tctgtagccg atttgatcag ctggagaaag      2760
     ggtatcagtg attgaagatc aaatgaatga aatgaagaga gaagagaagt ttagagaaaa      2820
     aagaataaaa agaaatgaac aaagcctcca agaagtatgg gactatgtga aaagagcaaa      2880
     tctacatctg attggtgtac ctgaaagtga tggggagaat ggaaccaagt tggaaaacac      2940
     tctgcatgat attatccagg agaacttccc caacctagca aggcaggcca acattcaaat      3000
     tcaggaaata cagagaatgc cacaaagata ctcctcgaga agagcaactc caagacacat      3060
     aattttcaaa ttcaccagag ttgaaatgaa ggaaaaaatg ttaagggcag ccagagagca      3120
     aggtcaggtt acccacaaag gggagcccat cagactaaca gctgatctct cggcagaaac      3180
     tctgcaagcc agaagagagt gggggccaaa attcaatatt cttaaagaaa agaattttca      3240
     acccagaatt tcatatccag ccaaactaag cttcataagt gaaggagaaa taaaatcctt      3300
     tacagacaaa caaatgctga gagattttgt aaccaccagg cctgccctag aagagctcct      3360
     gaaggaagca ctaaacatgg aaaggaacaa ccggtaccag ccactgcaaa aacatgccaa      3420
     attgtaaaga ccatcgaggc taggaagaaa ctacatcaac taacgagcaa aataacaagc      3480
     taacatcatg acaggatcaa attcacacat aagaatatta accttaaatg taaatgggct      3540
     aaattctcca attaaaagac acagactggc aaattggata aagagtcaag acccatcagt      3600
     gtgctatatt caggaaaccc atctcacgtg cagagacata cataggctca aaataaaggg      3660
     atggaggaag atctaccaag caaatggaaa gcaaaaaaag gcaggggttg caatcctagt      3720
     ctttgataaa acagtcttta aaccaacaaa gatcaaaaga gacaaggctg ttacataatg      3780
     gtaaagggag caattcaaca agaagagcta actatcctaa atatatatgc acccaataca      3840
     gaagcaccca gattcataaa gcaagtcatg agtgacctac aaagagactt agactcccac      3900
     acaataataa tggaaggctt taacacccca ctgtcgacat tagacagatc aacaagacag      3960
     aaagttaaca aggatatcca ggaattgaac tcagctctgc accaagcaga cctaatagac      4020
     atctacagaa ctctccaacc taaatcaaca gaatatacat tatcagcacc acatcacact      4080
     tattctcaaa ttgaccacat agttggaagt agagcactcc tcagcaaatg taaaagaaca      4140
     gaaattataa caaactatct ctcagaccac agtgcaatca aactagaact caggattaag      4200
     aaactcactc aaaactgctc aactacatgg aaactgaaca acctgctcct gaatgactac      4260
     tgggtacata aagaaatgaa ggtagaaata aagatgttct ttgaaaccaa tgagaacaaa      4320
     gacacaacat accaaaatct ctgggacaca tttaaagcag tgtgtagagg gaaatttata      4380
     gcgctaaatg cccacaagag aaagcaggaa agatctaaaa ttaataccct tacatcacaa      4440
     ttaaaagaac tagagaagca agagcaaaca cattcaaaag ctagcagaag gcaagaaatg      4500
     actaagatca gagcagaact gaaggagata gagacataaa aaacccttcg aaaaatcaat      4560
     gaatccatga gccagttttt tgaaatgatc aacaaaattg atagactgct agcaagacta      4620
     ataaagaaga caagagagaa gaatcaaata gacacaataa aaaatgataa aggggagatc      4680
     accactgatc ccacagaaat acagactacc gtcagagaat actataaaca cctctatgca      4740
     aataaactag aaaatctgga agaaatggat aaattcctcg acacatacac cctcccaaga      4800
     ctaaaccagg aagaagttga atctctgaat agaccaataa caggatctga aattgagaca      4860
     acaattaata gcttaccaac caaaaaaagt ccaggaccag atggattcac agccgaattc      4920
     taccagaggt agaaggagga gctggtacca ttccttctga aactattcca atcaatagaa      4980
     aaagagggaa tcctctctaa ctcattttat gaggccagca tcatccttat accaaagcct      5040
     ggcagagaca caacataaaa agagaatttt agaccaatat ccctgatgaa catctatgca      5100
     aaaatcctca ataaaatact agcaaactga atccagcagc acatcaaaaa gcttatccac      5160
     catgatcaag tgggcttcat ccctgggatg caaggctggt tcaacatatg caaatcaata      5220
     aacgtaatcc agcatataaa cagaaccaaa gacaaaaacc acatgattat ctcaatagat      5280
     acagaaaagg cctttgacaa aattcaacag tccttcatgc taaaaactct caataaatta      5340
     ggtattgatg agacgtatct caaaataata agagctattt atgacaaacc cacagccaaa      5400
     gtatcatact gaataggcaa aaactggaag cattcccttt gaaaactggc acaagacagg      5460
     gatgccctct ctcaccactc ctgttcaaca tagtgttgga agttctggcc agggcaatca      5520
     ggcaggagaa agaaataaag agtattcaat taggaaaaga agaagtcaaa ttgtccctgt      5580
     ttgcagatga catgattgta tatttagaaa accccattat ctcagcccaa aatctcctta      5640
     aggtgataaa caacttcagc aaagtctcag gatacaaaat caacgtgcaa aaatcacaag      5700
     cattcctata caccaataac agacaaacag agagccaaat catgagtgaa ctcccattca      5760
     caattgcttc aaagagaata aaatacctag gaatccaact tacaagggat gtgaaggacc      5820
     tcttcaagga gaactacaaa ccactgctca acaaaataaa agaggataca aacaaatggg      5880
     agaacattcc atgctcatgg ataggaagaa tcaataccgt gaaaatggcc atactcccca      5940
     aggcaattta tagattcaat gccatcccaa tcaagctacc aatgactttc ttcacagaat      6000
     tggaaaaaac tgctttaaag ttcatatgga accaaaaaag agcctgcatt gccaagtcaa      6060
     tcctaagcca aaagaacaaa gctagaggca tcatgctacc tgacttcaaa ttatactaca      6120
     aggctatagt aaccaaaaca gcatggtact ggtaccaaaa cagagatata aaccagtgga      6180
     acagaacaga gccctcagaa ataataccat gcatctacaa ctatctgatc tttgacaaac      6240
     ctgacaaaaa caagaaatgg ggaaaggatt ccatatttaa caaatggtgc tgggaaaact      6300
     ggctagccac atgtagaaag ctgaaactgg atcccttctt tacaccttat acaaaaatta      6360
     attcaagatg ggttaaagac ttaaacgtta gacctaaaac cataaaaact ctagaagaaa      6420
     acctaggcaa taccgttcag gacataggca tgggcaagga cttcatgtct aaaacaccaa      6480
     aagcaatggc aaccaaagcc aaaattgaca aatgggatct aattaaacta aagagcttct      6540
     gcacagcaaa agaaactacc atcagagaga acaggcaacc tacagaatgg gagaaaatgt      6600
     ttgcaatcta ctcatctgac aaagggctaa tatccagaat ctacaaagaa ctcaaacaaa      6660
     tttacaagaa aaaaacaacc ccatcaacaa gtgggcgaag gatatgaaca gacacttctc      6720
     aaaagaagac atttgtgcag ccaacagaca cgtgaaaaaa tgctcatcat cactggccgt      6780
     cagagaaatg caaatcaaaa ccacaatgag ataccatccc acaccagtta gaatggcgat      6840
     cattaaaaag tcaggaaaca acaggtgctg gagaggatgt ggagaaatag gaacactgtt      6900
     acactgttgg tgggactgta aactagttca agcattgtgg aagacagtgt ggcaattcct      6960
     cagggatcta gaactagaaa taccatttga cccagccatc ccattactgg gtatacaccc      7020
     aaaggattat aaatcatgct tctataaaga cacatgcaca cttatgttta ttgcggcact      7080
     attcacaata gcaaagactt ggaaccaacc caaatgtcca tcaatgatag actggattaa      7140
     gaaaatgtgg cacatatata ccacggaata ctatgcagcc ataaaaaagg atgagttcat      7200
     gtcctttgca gggacatgga tgaagctgga aaccatcatt ctgagcaaac tatcgcaagg      7260
     acagaaaacc aaacaccaca tgttatcact cataggtggg aattgaacaa tgagaacact      7320
     tggacacagg gtggggaaca tcacacacta gggcctgtcg tggggtgggg gtagggggga      7380
     gggatagcat taggagatat atctaatgta aatgacgagt taatgggtgc agcacaccaa      7440
     catggcacat gtatacgtat gtaacaaacc tgcacattgt gcacatgtac cccggaactt      7500
     aaagtataat aataataata aaaagagtca gccccctagc ctggcagtgc tgctctacag      7560
     gcaccctcag ccctgatccc ttcactgcac ctaggggaca cagtttacag gactgagtca      7620
     gtgggacacc ctgttccttt acattcccag tcatgggctc agattctgca cttgtctcac      7680
     tgctggaggg aggagcctgc atcagtcacc ctcaaagaag acatgaagtt atttcacctg      7740
     taaaggcaag aaactgttcg cagcactggg ggcaggcttg gggaagatga ggtttgtgag      7800
     gatgttgaga attcatgcag ctcatccttc agccctatag ctttccagag aagtgtataa      7860
     tgggggtcac taggcatgtg agtaactgat ttggtgaaag atgccacttc agatcaaaag      7920
     tgcatttccc cttccccaag gtgtcagcaa cactgaaaca tatttgacta actttataga      7980
     ggaagattaa gatagaggat gagagagaca taaggcctca ggaatatctt agccaataga      8040
     aagcctgctg gaagatgcat ttccaatatg attagactga ttgaaaacct tgaaactaaa      8100
     cacttccaaa ggagactggg acccatttct cctgagaatg acaacacaaa aaatagtaga      8160
     ggaaaccaac aaaccaaaag cagacactgt ttcagatcta ttgaaaatcc tcaagatagt      8220
     ctcataatat aatattcaaa atatctagga tacaattcaa agaaacactt gttatatcaa      8280
     gaagtagaaa aattcaccat ttgaatgaga aaaggcaatc cagacatcaa cgctgagatg      8340
     atttagggct gaaattacct gacagatata ttgaaatcag ccaccataaa atcctgttga      8400
     tgagcaattt caggcattct tgaaacaaat gaaaaaggat aaattctcag aaaaaataga      8460
     agtcataaaa tcaaactaaa tataaataca aataaaataa atgaaaaatt taaaaatacc      8520
     tctctggaga gactcaagaa caagtaacta tgaaactaaa atccacgcat tagagaagac      8580
     acttaacact gttaactaga gaagcacaaa ccatagttat cacagcccag cagggcgagc      8640
     aatcagtctg ctcagaagtg agaggcctga aaaaaaactc ctggtgtccc tgatggtgaa      8700
     atctggcccc tgatcccagg gttcctccct cttcgtgctc agagggctag acctagcagt      8760
     gaagggttcc caacctcacc ctatgcggcc cctccagaag gcagagccca ttcttgctga      8820
     tattcccgat ctccaataac acaaagtgaa agagaatgtc ttaaccagag tactgagtct      8880
     tggcctatct gaacatattt caaagtttaa atgtacagtg agcataggat gctgagcaga      8940
     ggccccctgg acagtggctg gagttgggag cagtgcagga tggaaggaca ggtcaggggc      9000
     cctgagcacc tgtacctgca cctgcacctg cccagggtgg acatgactcc cgcatccacc      9060
     agagggcgtt gtggtctaag caactaatca gagctcccca gatcctctgc tgttttccct      9120
     ccacctgctg gtgtttctgt gccctccaga tggtgttgct cctccccctt ctatgaccac      9180
     ttttcagcca taaccttgtc tgaggtcaaa ggagggggtt gtgcaacctt cagaaaggga      9240
     gaaatttgca tggagcccta ccactctgag gatacgcgtg acagataaga agggctggtg      9300
     ggatcagtcc tggtggtagc tcaggaagca gagcctggag catctccact atggcctggg      9360
     ctccactact tctcaccctc ctcgctcact gcacaggtgg ctgcctgcaa ggaattcagg      9420
     gagcgttcct ggatgtcacc tgggctgatg atctgttcct cctgcctggg aaccagtctt      9480
     catctctccc gactgatctc tgtgttgctc tcttcttgca ggttcttggg ccaattttat      9540
     gctgactcag ccccactctg tgtcggagtc tccggggaag acggtaacca tctcctgcac      9600
     ccgcagcagt ggcagcattg ccagcaacta tgtgcagtgg taccagcagc gcccgggcag      9660
     ttcccccacc actgtgatct atgaggataa ccaaagaccc tctggggtcc ctgatcggtt      9720
     ctctggctcc atcgacagct cctccaactc tgcctccctc accatctctg gactgaagac      9780
     tgaggacgag gctgactact actgtcagtc ttatgatagc agcaatcaca cagtgctcca      9840
     gacccatggg gaagtgagac agaaactccc cagagcatct ctacctgggc cagtctcagc      9900
     ctgtctccac cagagagggt agctctccca tctctcctgt ctaagtgctt gaggtgaact      9960
     ttgcttatga cttcctcttt tccttttcaa aataccaatc tgtttttcca caccttgatg     10020
     gctgattttc tgatatgtgc acgatcaatt gtgggataaa tgtagtttat aatcgggtct     10080
     ctgagccaca ccatgattga tgttctggtt ggggctgcct tgcacagtat aagttattga     10140
     cttgcatctc tggcctctac ccttagatac tattaacacc ctcccctcat ttgtgacaac     10200
     aagactgtct tgagacactg ccacatgtcc catgcttggg gacaaaatca gcccaggttg     10260
     agatactcag ttaaagagca tgtcttcagc tactaagaag cttggctttg aaatgtgttt     10320
     atgccattct gctgagcatg aggctggttt tctaattttt gtttctggtt cccatctatg     10380
     agacaaaaca ataacaccaa acttcaatgt tttgatggtt gaatggtttt tccaagcaac     10440
     aagaagtcag agattgtgct acttagaggt gtagaagccc taaccagatc ctgtaacaca     10500
     gagtttagct ctgactagga cagcacacaa tgccttccat caatctccaa cccacagccc     10560
     gcaggctgca tgcagcccag aaaggctttg aatgtggccc aacacaaatt tgtaaacttt     10620
     cataaaacat tatgattttt ctgcaatttt ctatagctca ccagctattg atactaacag     10680
     ttagtatcag ttttatgtgt gttccgagac aattcttctt ccattgtggc ccagggaaat     10740
     caaaagatgg gacacccctg ctttgcactt ttgtacaatg cacatggaaa tataatagag     10800
     ccttcttcct tctaaggtca tgtgactcag ccattgaaag gtggaagtgc tgaaatgagc     10860
     tccatatgaa cggaccttga aaaattatgc tcagtgaaag gaacaaatgc aaatatctag     10920
     aaatgaaatg tctggaaatg actgtattta taacaaatgt ccatgatacg taaattcatg     10980
     gaggctgaaa agatcgagat tatcctcaaa ccttgtgata atttaggtga aaaggatgat     11040
     ttcagaattg gatagaaagt gatctacttc aaaaataagc tggaaatgcc tccacgaaca     11100
     gaggcgatgc tttgcggaat cctaggtgga gaagtgtatc aggtgcagat gaggtcttta     11160
     agaatacttc ttgttttgtt ttgtaaaatt aaatatgaat aagaacactg tgggccaggc     11220
     gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggccggtg gatcacgaga     11280
     tcaggagatc gagaccatcc tggctaacac agtgaaaccc tgtctctact aaaaatacaa     11340
     aaaaattatc caggcgtggt ggcaggcacc tgtagtccca gctactcggg aggctgaggc     11400
     aggagaatgg cgtgaaccag ggaggcggag cttgcagtga gctgagtttg cgccactgca     11460
     ctccagagcc tggctgacag agcgagactc catctcaaaa aacaaaacaa aacaaaaaaa     11520
     cactgtgctt gctcgcttac ctcctcctca ggtcatttcc tgcagtctct aagaacagtc     11580
     cgcctggctt ccccatctcc tccctgagcg ccagcatctg gggcgtgaac agcacaatca     11640
     aggccacacc tgtgagaccc tcagtgcgtc agcagagctg tgtcctggtg atgtcaaggg     11700
     acacggggtc agcaggggac ctgtgaggct gtctcagggg gtgagcatgt ctggccctgc     11760
     cagctgggaa ggccctcagg aggttgaggg gagctgagca cacagtgagc tcactgagct     11820
     gagatgggaa gtgactgcag ctgtcaggac cttcagggac actcagtcta ggatcaggct     11880
     ctctcaccct gtggggcctg gttcaggtca actcctcatc ctcctcttct tcctccagac     11940
     aagagagaca ttgcctatgg ctgaggggtc ctggaggtga tccgggtgca gggacttatt     12000
     tgaatgtagg aaattctctc ccagtgagac ctgtagagac taaaagagcg ttaggaacat     12060
     tcactgttac ggctggagtc ttagggtgca gatctcttga gcacctgcac catggcttgg     12120
     cccctctgct ttttgacctc ttccctccct gcccagctga ggcacatcct gctctgggga     12180
     gaagggtcta tgcggtcctc agcccacctc tgctccactc cctttctcac agggctcatt     12240
     gttttctctt tctctccacc ctcctgggtc tgtggtccac atggcactga cagcctcttt     12300
     cactgaccaa gcctccggga ctgacaatta caatcaccca ccctggaaac agccataata     12360
     ctgtcaatca aggcacagct tggattcagg agcacctggg acatgtcccc aaacctcaga     12420
     cccagagggg gtaacaacca tccctcaggg acctcaggga atttcccagc cccatgttag     12480
     gcagtttggc ctccctggcc atctctgggc tccaggctgg cgacggtgct gattttcact     12540
     atttagcaca gaatggcagc ctcgctgatt attctctgat tatctggatg ctctgtgact     12600
     ccttctgtgc atctctggga tcatcattca gactcacctg caccctgagc agtaacatca     12660
     atgttgtttg ctatgacatt tactggaaac atgacagggc agggagcctt ccctccctgg     12720
     tatctactga gattctactg agattcaagc agaaccaggg ctcagggtcc ccagcctctt     12780
     ctccgtgtga gtgggtgccg tcgccagtgc tgaggctttc catatctttg gtctcaagct     12840
     tgaggatgag gctactcatg gcacagtagt gcctctcaca gtgccatgga tgggatgttc     12900
     tctctaaaat agaagtcttt tttttttttt agtttggccc ctttgataag tagattctat     12960
     aataattaaa gaaaaaaagt aatgtctttt ttggagagta gaaacactgg tgaaagagaa     13020
     accgggaagg acttggcatg gggggtgggt gggcttcagg ccacggctct gacccccacg     13080
     aaaggagaga aggaaggggg attagtagga actgccccag cccacaggca ggtcagacct     13140
     cagacaaagc ctcagccaac tgagtgggtt ctttcccacg ggtgcccatt acaagtgccc     13200
     tgcttcctgc aggaagacct gcctggaggg accctggggt ccccattgcc tggagccagc     13260
     ccacgggcag gggacatgtt agtcacttgt ggtcctcctg cacgttctcc caaagaggca     13320
     tctgagtggg acacttccac agccgccacc agcactgctg ctgcattccc cctcaggaca     13380
     ggggcagtgc cttccttccc cggctcatct acctgagccc catgtgaagt caaagcttag     13440
     gtgtctcagg gctttcctcc aacaggccct gcagccactg agacccttat ataccctgag     13500
     ctgcatgctg tggagagagg gtctgtggaa gaccttggct cttagccatc gactcctctg     13560
     gggaacacca tgaaatcctc agactgggga tgtcctctgg agccatcttt atcctcttct     13620
     tcttcccagt atctcctgct ccatgatctg ggtcctgtcc ctggccctgt tgcatctcca     13680
     gtgtctgatc catgccagcc cttccttaaa tatgtgttga acccatttcc catttgccca     13740
     agaaatgagt gctggcaatg agctgcactt tttttttttc taaatgggaa atgggtcaat     13800
     aaatgaatga atgaatgaat aacaacgcaa cctgagtctc ctgtcacatg gttattttaa     13860
     gacctgcgtt tttctttacc caggaggaaa atgagtacct gcagccgtta ttgcctctga     13920
     attgagctaa cttgtttcta cactgtcatg ccatggtcac agtgggacag atgtacacca     13980
     agcctaccat agctttcagc cctgcccttc cacccgcccc acctgtggca gtgatggcat     14040
     caaggcttcc ctcagagtcg gcctctaccc accacacact ctgggccatc tcctgctctc     14100
     caacagcctg gggttcagtg atccctgtcc atgtgttcta cctcagagac acctgccact     14160
     cctccccttc cctaatttct ctgccatcct gtttctccag cctcccagga atgtcccctg     14220
     cccaatctca tgtctcaggt tctagaactt gtcctggaac ttccccagag ctgagtctct     14280
     aataggagag ctgatgacag gcacagccgt ggtcaagccc tctagccagc agatggagga     14340
     gaatcagcct gagggccctg tgcatcctcc ctgctgcaca cctgggccca tagccccctc     14400
     caccctccat atgctcctgc agcccccacc tcagtgtctg cctcagtgtc tcctcccagc     14460
     accttcctca ggaagggcct gagatcttgc atggtgtgtt tccccttggt gaactcctag     14520
     tcacagcagc atcccgagta agagcctcct ggtgaagaga tcgtcttggt gctccaccct     14580
     ggcattgtgt cctcagctcc agggcaggtc acacgctttc ctggaccaag attacatgca     14640
     ggccacccct gctggcccct gccccacaga gggaggcccg gggtcagggg tggcaccaag     14700
     accacagctc cattgatccc tgtaggaatt cttcctgcat gtttgaaaga caagagttac     14760
     agaaacaaag cagagggaag attctgggtc attgcaaaag gagaaatttg cctgcagacc     14820
     agcaggggac gcggtgagac cttctctgtg tatttctgca ggacaggtgc tcacagctgg     14880
     ggagccctca actgacagag gcccagggct gctccttcat ttcctcctgg gactctgcag     14940
     ccttgtccca tctgtgcctg gcagagtcct ctacacatga ccctgtgtgt ggtcccagca     15000
     gctgctgctt tctctggtcc cacccgtggg gcaaactctt gcttcatgcc agcctccctg     15060
     tccaagggcc tggtccctgc gagtgcacct gggggagagg caatggggaa acacatttgc     15120
     atggtcagcc cctcctctgt gagcccagtg acgctgggat aagagaggcc tggggcagcc     15180
     cacccctagg tctgtggcct cagaggcagc tgtgtccact atggccctga ctcctctcct     15240
     cctcctgctc ctctctcact gcacaggtag ggacagggct cagagcccag ggtggtcccc     15300
     agcctgatct gtccctcatg gctcagatcc ctcagcagct gcgccctgac cctgctcctc     15360
     actgtgctgt gtctgtgtct gcaggttccc tctcccggcc cgtgctgact cagccgccct     15420
     ctctgtctgc atccccggga gcaacagcca gactcccctg caccctgagc agtgacctca     15480
     gtgttggtgg taaaaacatg ttctggtacc agcagaagcc agggagctct cccaggttat     15540
     tcctgtatca ctactcagac tcagacaagc agctgggacc tggggtcccc agtcgagtct     15600
     ctggctccaa ggagacctca agtaacacag cgtttttgct catctctggg ctccagcctg     15660
     aggacgaggc cgattattac tgccaggtgt acgaaagtag tgctaatcac agtgagacag     15720
     atgaggaagt cggacaaaaa ccaaggtttt aagcttgtca tttttactga actggttaag     15780
     aacttcagtg gttaataaaa tcacattaaa tacaggattg ttgttaaaaa tggtggcaca     15840
     ttataactct ctcccatttt tttcacataa tgcccatagt gactctaagc agctaaaatc     15900
     aaaacacaaa aacttatacc aatactaaga aatactaaca ttactaacca atttccacta     15960
     gtaaaagagt tgtgaaacag ctgaaataca tccagatggc ataatacata ataccactat     16020
     atacaagagt tgtataaaat tatgtatcat gtatatataa aattatgtat catgtatatg     16080
     tataatatat gaaataaaat gtcagcagac attaccgtct tcccaccagt agccagcaat     16140
     tctgccctgc ctctagaata aatggttacc acgggttgaa taggcgaaca gccctggcag     16200
     ctctgcagga tgactctcac tgtttgttat tgttttattt ttaagattgc ttttctttcc     16260
     tatttttttt gaggcagagt cttgctgtca gccaggctgg agtgcagtgg agtgagctcg     16320
     gctcactgca acctaagcct ccctggttca aacgattctc ctgcctcagc ctcctgagta     16380
     gctgggatta caggcgtgcg ccaccatgcc tggctaaagt ttttgtattt tttagtagag     16440
     acagggtttc accatgttgg tcaggctggt ctggaactcc tgacttcggg atccgccgtc     16500
     ctcggcctcc caaagtgctg ggattacagg cgtgaaccac cgtgcccgac ctcttttttt     16560
     ttttttttta gtttggtttt gttagtttag ttttgtttta tctctttaac ttgacagtca     16620
     gagatgatcc atgtggatct ctgcatgggt ctgggagctg caaggctcct ggtgcatggc     16680
     ccggtcccgc ctgccttggc agggctcctc cacctggctc ctggaggagc agctgcgccc     16740
     gactaccctg catggagccc gcggcttagc ggcagctcgg gaggggcctg atagaaactt     16800
     ccccctgagc aagcagcgcc aaacccaggc cgccacccag gatggaggct gcatcacccc     16860
     cggggagccc ggatcctcgc cagggtccac caggagaaga gcacatggcg gagatgagcc     16920
     tgcggggctg ggagagagag aagacacggc gaagctgcag gtgaagacgc tgcactaagg     16980
     ccccacccag aggctgaggt tccccgacca gaccagcagc agcgaggctg cccagagcgg     17040
     cgccagcaag gtggttctct ccaggtcgga tcacaggaga agctagcctt gcacctggcc     17100
     caggcaagaa gcaggacatg ggcttacgca gaagaatcag caccgattcc acatcattcc     17160
     ccatggcaac ggcctctacg gtgctgtcag caagacccag tgctagaccc gagcctgcac     17220
     caggagctgc ggagcggagg gtgcgcccca tcccgatcgt ctccaccact ttagctccct     17280
     gggtgagggt gacacgggga agcttattat cgcggctgcc caaaacgggg cgtggctggg     17340
     taccctgtgt acatagggta gatgctgaat gtgaatagca ctgaactact agagggaggc     17400
     tggagaggcc cacagtgtct atctaccatg attcattatt tgggcccaga ggattgccta     17460
     aggcctagta tttggctcag ttggctcagt aacgggcact aggatgcagt atttgatcac     17520
     tcctatccta accaagtacg acaactggtg caaacagact caaaagcaaa ggcaacgcaa     17580
     tgaataactt gctcactctg gggccacata tgctgaataa aatgcctacc cttgaaatgt     17640
     ctgaaaacct tacaccctgg gaaaattgca tacagaactt gtgcttggag aatgacatga     17700
     actctaatca gggtaataac acttgtaaag ttcctaacag cttttctttc cttttttttt     17760
     tttgtttttg agatggagtt tcgcagtgtt gcccaggctg gagtgcagtg gcgcgacctc     17820
     ggctcactgc aagctccgcc tcctgggttc acgccattcc cctgcctcag cctcccgagt     17880
     agctgggacc acgggcgccc accaccacgc ccggctaatt ttttgtattt ttagtagaga     17940
     cggggtttca cggtgttagc caggatggtc tcaatctcct gacctcgtga tccacccgcc     18000
     tcggcctcct acagcgctgg gattacaggc gtgagccacc gcagctggca cttcctaata     18060
     gcttttctgt gagtgtaacg ccataatcat cttttaaaat gttttctcgg aactaaaagt     18120
     tgctgggcgc ctaaatgatg ttgcatgata gttttgggtg attttactgc atctgtaatt     18180
     ttctgtttaa gtgagcaccg cttaatttga aagctaattt ctcacagtgt aaatctgttc     18240
     attcctggta gtctattttc tacaaaagtg tatttttaca caacattaaa aaatggtgta     18300
     ccttcatcta tgacagtaca ttacttttga caagcagctt tcaggcagaa attaagagaa     18360
     gtgttttata taaaatttat tattttgaac agagtttgtg atttggtagt tacgctgttg     18420
     aaatttgaat tttacaattc ttagaaactt atattgatgc attcttgtta ccaaatgatt     18480
     ggcccattac attttgatac aaatagattt gttgttttgg aaccattatt tgtttagaaa     18540
     tggtcaatct tttagagaga aatacttaac aaaggattgt gggaagtttt ttttttcttc     18600
     ttctttaacg gattgtacca ggtcttactt gaatgaaagt ctgatgcttg ctgatggcag     18660
     agtgactaat ctgcactaga ttgatgttta gagcagaatg ttgggtgatc tcaattgttt     18720
     ttatttatgt ttgtgatttt gttttaaggt aatcttaaca tggtataaga ctctgtgaca     18780
     agctaaacct actgcaatat agcatgttgg agtcccctaa gagttttaaa agctaatggc     18840
     ataaatgcct ggagccaacc tcggcagtta tttcatagca gaagataccg tcttaatatt     18900
     ccttttaaat tcttttaaaa ggcaaaatag gatcatccta ttttataatg tacaaatgtc     18960
     tgcagagatt gtatggtttg ttgtgttaat gtttcccacc taaaatctat catattgcca     19020
     ctttgcctaa ttgtagtcac atttattaag taatgcagtt tgtacttttt attttgtaac     19080
     attctgtgat ttttgtacaa cattgtattt gtacaataca gcaattccca gttgattgaa     19140
     tgaataaata aaatgtaaaa tcatacttta taaaaagatc tatgtggctg atagaattct     19200
     gacattcccc tccaaatgga aagtgatgtg tttctttaaa gtaaaggtag aggagtctta     19260
     aatataggtg ttcctgcccc tattgagagg ttttcaaaac atgctcttaa tttaacgttt     19320
     aaatatacca gagtcttaga atgtgagaat aatgaaattg gtttgtttta attttgtgat     19380
     aatattaaat ctactggaaa gaatattctc ctttgaaaag attctcagct cagtgatcat     19440
     agaacctgta cttgcgttta attcaatgag gaaagacata gaaatgccac gttaatatcc     19500
     tcatttaggt ggtttctccc ttcactgatc agcctatgaa tgtgtcaatg cagtactccc     19560
     cagtttaggc ttaggtactt attgaaagga tgctgcctga gcatttttaa taattgctat     19620
     ttcaagatca cattttggcc atgaggcagg ctgccactca ctttaggctc tgcctaggca     19680
     ggaatgggtc ctggaagaca catgttctct ctctctctct ctctctttca cacacacaca     19740
     cacacacaca cacacacaca cacacacaca cacccctctc ttctctctgg gtacacatta     19800
     ttctggacat cttcagtttc caggattctc tatgtctcca gctagaagtc agggcttagc     19860
     ctgtggtgat ccagccaccc tcaggttgaa tctcgatgaa gtcacaggaa ccaccagtgg     19920
     catggagggt aagggatcct gctatcaggt tcagccagga aatgctctgg acacctgctg     19980
     gtggaagagt ttaatgctgg gcaatcacaa gtcaggtccc ttcttccagt cggcagttca     20040
     gcctccctga ctttctctgg gttccagtca gtgcatgagg atgatggtga catttattca     20100
     ggggcagcac agcagcctca gtcaccacca acagtcactg tcatatgaga aaattagata     20160
     gaaattggcc ttccaactct tctgtcagat ccatctttgc cctttttctg cctgcttgag     20220
     tgaatacgac caagaccagc tcaggttttt gctgatgcta tcacacgtgc tcctaaaacc     20280
     agaaggctta atggtatttt ctgtttatct ttacggattc aatgaaaaga caccttttct     20340
     tactggtctc ccaatgaaaa cataatcact atgtccacag taacaaagat agccctcgtt     20400
     gttgtctgct gggatgagaa gagcagcaga agtttggcag gtatggccct catgggcttc     20460
     acatgtccct acatctggcc ctggctttgc tgatcaccct ttgggctctg aacccacagg     20520
     gaagttaggt ttctctttct tttgagattg cctctggaag agctgctctg ttcccaggtg     20580
     cagggcagcc cctccgcagt aaggacccag ctctcagagc catgaaggcc tcaagcctcc     20640
     aggttgactc cacatttcta gtgcttgtct ctggttcttt ggttggaaag atgttggatg     20700
     aatagaagtt ctctgagacc taggctttgt gaatccaacc cccattaaat ccagggatct     20760
     ttttaacgaa taaaatgaat cagggcccag tgatggtggg gaaatgggac gtgagggttc     20820
     ctcaggccag tagtatgggg agaacatcca aaaagaaagg aggggttcca cttttgagaa     20880
     ttgtcttttt atatccatcc acatattgac gaaaattata aaattagact aaaatacctt     20940
     aaatatataa catggtcaaa agaaaagagg tattaccagg ataatattaa atagtaaaag     21000
     aagtcagagg cgaaacagag caagagacac tttttttctg acagcatcat tcttatgggc     21060
     tataatgcca aggcttgtgc agtaggagct gaaggaatct cacaggcgac cctcacgaca     21120
     ataatgacaa taacaaaata agtcaacctc taaaagaagc ccatgtagaa ttatccccag     21180
     gtatgaacca cctggaggct cagcagaaca ttaagcctta gattgggttc aagatgacca     21240
     cagactggtg atgaccacag gcccctggga gcaacacact cacacgcctg gtgatgctga     21300
     tatctggtaa atcatcactg tgcatcctga aacacattct gtgattagct ctttgcagac     21360
     cataactaac atgaaagaaa taatgcctca gctgtaaaca ctgcagagag gacccactca     21420
     ttctactccc ttaggtcatg agttgaaaga tccatttgca atggtcagga tgtccttcca     21480
     gaagagctgg gtctgttctg aggggccacc cgacttggga tcggagccca gcagggggtg     21540
     ctgttggact gttcctgaga gggcagggct ctgggccagg ccacatagga aaatactggt     21600
     tctcatacac ttgagcaagc agtgtcctca ctgaagtatg acttcctgca cctgcaccac     21660
     cgagcaggag ccacttcctg cacctcagga gccactgagc actagactca cacgccaatg     21720
     cttcctattt tatcctccgc cctcatggag tccttgtcca agcctgccct tcaagcagag     21780
     acaaatcaca cagcaggaac aaatttgctc aaaggaactt gaactacaat gtttcctggg     21840
     cacagaatga gaaacacttg gaattgggga agttcccatc ctaacaactt agactcagga     21900
     agaagaaccc tggagcttct ccagcatggc cagaatctca gtccacttca aaatcctcag     21960
     tctttagatc aggagttctt ttagggatga ggtcaaggtt tctgggtgca cattaccact     22020
     gcctttcagt cctatcatct gggcatgagg agcttgttat ctcgttctat ccattatttc     22080
     taaacctcct tgtagagggc tgggttagag agtgctaact gccatttata cagtctggac     22140
     ctttgtataa aattataaac acacacacat acacacacac acacaaacac aaacacacat     22200
     acttattttg atgttccagc gaaagagtaa aactaaactc aacagaaaca gaaacagatt     22260
     tgaataatac aagacaatct cattaatgaa catagaagca aaactctctc agaatattag     22320
     caattagagt ccattttata tcaatgaagg attatcttga gcatctggga ggatgtgggt     22380
     tgagacattt gcacagtcat tggaagacag tgaacatgat ttttgaaaaa acagcatgtt     22440
     tagagatatc aaccagaggt cagatgcttc aatcagagaa agatcctctg agttctcagg     22500
     gctgcttccc tgaaaagcta cgggagaagg aaatggagtg actggacaca atgccagggg     22560
     attcattgac cctttggctt cccatgggca gcatgcatca gcatggtctt acaaggatga     22620
     aaaagggcat ccctcaaaaa agaccgacca tttccccaga aattaataaa gaaatatcat     22680
     ggccgggcgt ggtggctcac gcctgtaata ccagcacttt gggaggtggg cggatcagga     22740
     ggtcaggaga tcgagaccat cttggctaac acagtgaaat cccatctcta ctaaaaatac     22800
     aaaaaattag ctgggtgcgg tggcaggcgc ctgcaatccc agctactcag gaggctgagg     22860
     caggagaatg gtgtgaaccc aggaggcgga gcttgcagtg agcctagata gcaccattgc     22920
     agtccggcct gggcgaaaga gcgagactgt ctcaaaaaaa aaaaaaaaaa aaaaaaaatc     22980
     acagtatttt caccagtgca tttctgtttg agcgaatatg ttgggtgaag aaatatataa     23040
     tatatacttt tctaaatgaa atttttatct cacaaaattg tagaattaaa tttttgtttt     23100
     ggataagaaa tcaagaaaca atcacacaca ttcttatgat ctcatgaaaa ccaggtatag     23160
     gaaaggaagt gacgacccca aaattcatct aaaaagtgaa ggttttggtt caaagataag     23220
     agggttgtca tgttcaagac aaagtcacta ccattcgtgg tatttaaagc tgttggtaca     23280
     agtgcctatc attgccgatt cccttcaaat ttcttgtgta tgtttggatc ttaaacatga     23340
     gcacacacaa aaagagaaac agcaaaacta gaaaacagat ttaccttttt gagtttccaa     23400
     ctggaggaga aaatgaacaa agagtaagaa tatcacatga taatgggagg aggagtgtta     23460
     ggaaggtgat gaggagcagt tcagccttcc cagcttgggg acagtcttag tggagcagag     23520
     aaacctcctt cctgctgcca cctgactctc tagagtagat gaagaataaa taactaaaca     23580
     taaaaagccc ttaggaaaaa gattgtcatg atgtcagtgc tattaatagt tcagttaata     23640
     attctgtaag aatatgcaaa aacttactgg ctttttaaaa atttttattt atttatttct     23700
     tttgagacgg agtctcgccc tgtcgcccag gttggagtgc agtggcgcga tctcggctca     23760
     ctgcaagttc cgcctccagg gttcaggcca acttactggc ttttatattt ggaatcacaa     23820
     cctgaaaggc tgcagaacat gaaaggaaga aaactcagat tgcagtgttc attctctttt     23880
     atattatgag tttcctgcaa gagctacatc tgttattatg caaaaacaaa cagataagga     23940
     aacaagaatt atccagcctc aagagtggaa taaaacatgc actttttttg cttgtaggca     24000
     taggtgagta attcagacac ggctgctgtg ggtgactcat ttccccttat gatggagcct     24060
     cagcaaaaaa gcttcacaga ttggggctga tttggtatga aggggttgga atcgactgaa     24120
     ggtgacctca ttgagagtct gcagtgaagc cggccttggc tgaatgacct acctgaggcc     24180
     tcccatgtgg cctgggtttc caggaagctg ggcagtccca gagaattcag agctctgact     24240
     tggtttataa agtgtcactt ccacagaaac tgtcagtgcc gagagatcac tagtgccaga     24300
     tctggttaac agggaggggc ctgatctcac ccctcaacgg aaggtgacgg gaaaacaaag     24360
     gaaaagctgt cttcacatca acatgggcag ataccacttt aaagcatatt ctgtagcagg     24420
     gttcccactc cagaagctgt ggtacaggat gtgtctccta tggcatgggc caagggaggg     24480
     taaaggtgag tttgacatct gtctcagtca ccatgaggtt tttctgacaa ctaaatataa     24540
     atatgtaagg tgtctcacag cacaatcatg tgacaataaa tgcagtgcgt gccttcaata     24600
     ttgctctatc aaggaggctt tccctccact ccaggtgtga gcacgtggct tgcatgtccc     24660
     tccactccag gtgtgagcac gtggcttgca tgtccctcca ctccaggtgt gagcacgtgg     24720
     cttgcatgcc cctccagctt cctgcactgt ggtcatactg ctgctgcctc attctcagcc     24780
     tgagcatccc tacacaggca caaactctat ggctcaggct ggtcatcact ctgggtccac     24840
     agtagctggt cagagagaaa ctgtcttcag ccctgcccag caggagaaaa gagcattcca     24900
     gactgatcag ctgggttcct gccatccaga agtccttgtc tgtctggagg ctcaaaacat     24960
     gactgtgatt cctttgagga ctcctcccat acccaggctg tgggcttcgc tgccctcctc     25020
     aggacccgtg cagcctgttc tatccctgcc tcagctgcag gcaaagctgc ttgccacaag     25080
     ctccctgctc ataggatgcc ggagtcctcc caagggctgc tcttcctgga gaagaaggag     25140
     aaccaggcag taaggtctac ctgagcatca tgggaaggaa gtgatccgat tctgactccg     25200
     gtgggcgcac acccttggtg ctttgtgtct cctgctatcc cagccacagg agtgggggaa     25260
     atgtgtgagt tgtagtccta gccgggaata atccataaaa ggtgaaggtg agagaaggac     25320
     actatgcatg gtgtcacctt gttttcctcg ttgtttcagc ggcctgagtc ctgtgtttcc     25380
     tgaaagatct gtggctcgag gtgacacgcc ctatcagggg acaggaatca aagaggagaa     25440
     tctctgatgg aaaaattcac aaaggaagag ggagataaaa attgggcaac atgctcaggg     25500
     tgagaacgat ggctttttgt ccttgtgata gtttgctgag aatgatggtt ttcagcttca     25560
     tccatgtccc tacaaaggac atgaactcat aattttttat gggcaaggac aaacaaccaa     25620
     acaccgcatg ttctcactca taggtgggaa tcgaacaatg agaacacatg gacacaggaa     25680
     ggaggacatc acacaccggg gcctgttgtg gggttggggg agtggggagg gatagcatta     25740
     ggaaatacac ctaatgtaaa tgatgagtta atgggtgcag cacaccaaca tggcacatgt     25800
     atacatatgt aacaaacctg cacgttgtgc acgtgtaccc taaaacttaa agtaaaataa     25860
     aaaaaaaaag acggctttgt gtcaagggct atttatttag tgtctctcgt tcccattatt     25920
     aaataattta acaacaaaaa ttgccttttc tatgaatttt caggaaattc taaccatcat     25980
     tcctttatta aatatctaga tatgtacatc tacacatatg catatacatg tgcatatata     26040
     gacatatatt atattatata tatttgtgtg tatgcatgtg tgtatatatt tatatatata     26100
     tacatgcatg tgtatataca cacacaaaga caaattaaga aatatgggaa tatagtatac     26160
     ttctttaatt tcttaataat gtccatttat atctaaaaaa aagatacccc taaggttgaa     26220
     ccactagaat cattttattt ttaatgtgga acaatagaaa gcttatggcc cataaagata     26280
     ttggataaca tatttttcta gcaatatgag aaataagcaa aagtgtaaaa catttaaata     26340
     caataattta attcaaaaat atgaaataat ttgtattttt tagttgctat gtttatctac     26400
     caagaaggca ttatattatt ctgatgttct tacacattgt tgaattaaag cttgttaaat     26460
     acaaatgtta tcatatgtgc aaatagcata tcaacatttc tttttctctc atatattttc     26520
     agaaatcact ttaaaatgta gcagttcata atgttgacaa aatatcaaaa tctataaact     26580
     ctgggtttaa aaaacaatga aatacacagt acacataaga aaatagtgtc aaagctcact     26640
     actataagag acaatgatca atattgaaat tttctcttac atgaagacgc tcaaaacatt     26700
     ttagcagtga ctagtgaggt tgtatccatt ctcttatgtt tatatttatg tttaaaatat     26760
     tgtccttgag aaggagtgta ggtaggtata agcagaggtg gctgtgcgga tccaagattc     26820
     tagcctgccc ccttgataca gcccattacc ctagtcccat ccaatctcac acatggccca     26880
     tcatcatctt ctgacttgag cggggagaga gacggtgggt agagagggag gaaaggagtt     26940
     agttcagagc ataggagacg tggtcagaga gttggcagag ggagggaggg aggcacattc     27000
     tgtgggttca cgtggtgctt tgacaactgt ggatttactt ctgaatgaag catgaagtca     27060
     ttgagagtgt ggaacagtaa aatgatattg caaaataaaa taaactaaga ttccagtgag     27120
     catgttggga atcacaaaca ctcacagctg ggtgaataaa caagtgctgc catctggaga     27180
     aaagttcctc agcacacaag gagaagtgtg tttgcctctg tcaagcagaa gtccacctat     27240
     acagagacac aaggaaatgt ttataaagag atccttattc ggagcaaagt attggaagca     27300
     acataggtgt tcaacacaag tggaatttat aacacaagga gaagataaaa tgctagccag     27360
     ttggaagtaa tacaacttct tatgcgacac gaataaaaat ataattatca gttgaaaaac     27420
     aataacaaca aactcccacc aaattaaaca aaatcaaaag ctctcaagaa aaaaacaatg     27480
     tgccacttat tttaaagcag aaacatgcat aacgaattct tcaagcttat ataacgggct     27540
     ttttggaaag tagactggag gcacattatt tcacataaat gggtgtctta ggaagagatg     27600
     gagacacgta taatggctaa aaaatgaaat aaatccatag agaggttttt agtgtctagt     27660
     gataaaagta ctaataatat tacgtaatta aattccaaaa aattaataca gaaaaatatt     27720
     cttgatttgg gggtggtaac agatgattaa gtaaagcgag tctacatgag ctgctgatgc     27780
     agtggatgac aagctctctg cagctcattg ttagtgagaa ggcactgctt tgccagaaac     27840
     cccttttatt tagatttctc atggtccctg ggtccctctc caacaccatg agcagcttca     27900
     gaagaggatc aggataacca gtgactctct ggctaccatg gcccagttgt gtccgagagg     27960
     taagaaaggt ttgggatctt ggacagagtg ggacagtggg agaaattcct gagatggccc     28020
     caaccagcct ggaaaccact cagaacctgc attgaagttt agccatcagg gtgctcttga     28080
     gactcggttt gggctgcaac acagacctgt ggggacaggg gtcaccataa gccaggccac     28140
     ctccacccct gggtcagctc atctcctccc tctctgcttc agatctttga gtaaccagca     28200
     catggaggcc cgggaaaagt cagagagcaa gatcttattt aaatgctgtg actccacccc     28260
     catgaaggct ttgggagcta taaaaaagag acttagggga gcccagtctc caaacagagc     28320
     ttcagcaagc atagtgggaa tctgcaccat gccctgggct ctgctcctcc tgaccctcct     28380
     cactcactct gcaggtgaga gtggacctta cccagggatc tgcacccacc tctgctccag     28440
     cttctccact ccctggctca gtggactctg atcctgctct cacattcctt tctgtcccct     28500
     ctacagtgtc agtggtccag gcagggctga ctcagccacc ctcggtgtcc aagggcttga     28560
     gacagaccgc cacactcacc tgcactggga acagcaacat tgttggcaac caaggagcag     28620
     cttggctgca gcagcaccag ggccaccctc ccaaactcct atcctacagg aataacaacc     28680
     ggccctcagg gatctcagag agattctctg catccaggtc aggaaacaca gcctccctga     28740
     ccattactgg actccagcct gaggacgagg ctgactatta ctgctcagca ttggacagca     28800
     gcctcagtgc tcacacagtg cctcaggcca gtggggaagt gagataaaaa ctcaagagct     28860
     ccctcggcct cactgaacag gcctcacaga gcactgttta aactggacca cccaaaagac     28920
     aagggatgca ttcacaatag tgtacactat ttaggactgt taaaaatagg aacatgaagt     28980
     gaaattagca agcctgcctt attaacaaat gtgtgtaggg aacatcattg tttatatatt     29040
     agtagttaca tatatataat actagtgcat gaacatacat atgcactagc aattagtaaa     29100
     aaagaaacac taggtttaac taaggaaata tttattattc cagagttttc ttatccattc     29160
     catttgaaga tgctgggatc aagtcaccga gggtgctgct ctctggcctt gagaatccac     29220
     tcagcagggc caccagcagc ccctcccttc tgtggcctgc tcatgccctg tcttctcatt     29280
     agaatcccct tccctgctgt cacagggatc cctggactcc tccagatcca aatatgtcca     29340
     atacatttgg ttgaggcctc ctgggcccca cattactgtg taatctcaac acccacacac     29400
     tcaaaacagt gttcccatgc gtattcttct ttcgactcat cactgtcctc taacagccat     29460
     gggcagtgtg tggagagagc aggtgaagtt ggagctttgg ggtacagttg acagagatgt     29520
     tgacattttg agaaaaagaa aacacctata tagctgtttt caggataatt ttccatcaag     29580
     ataaaaatcc acgcatgaga gcatcactct tccagtgatg aatgcatgga ggatccttct     29640
     cactctattg ttgggtagtg acacctggga aacttactgt gttatttagt gtgcagacag     29700
     ctggtaaacc actcagctga ctctagggaa gttgaccaaa cagtgtcccc actgatgtgt     29760
     gacttttctc cacccatgag gccccactac cctgtcacct cctgagtcca cctttcccat     29820
     tgcgttgctt tagatttgag gcatctctct cttacctctt taaagtcttt acccaagtct     29880
     ggttcaggaa gtgctgatac acggtgagaa cccagggtgc atatggatgg agtgattctg     29940
     tgcctaggag agcctggcca ggggatccaa cacagcttgt ggccatcctc cccgcagtgg     30000
     agcttctgga gacagagctc tgaggtgtcc ccaccacacc ctggggcctt tctccctcag     30060
     ttctttataa aagggatatt tgtcatgggc ttaggggaag aggccgctga ggtcacacaa     30120
     gacctgcctt cttgctctgg ctcacaaggc acaagtgagc tgtgaccctg gactctgtgt     30180
     cagtgctgtg gtcacttggt cagaactaag ggaagctgga gaaatgtggg tagctttgat     30240
     gcagtctggc accagaagct ccatcctgaa gcactctgaa ggtgctgatg gctgttcact     30300
     gtgctgcacc ctgagcagga ggatgatcat catcgcagac ctagggtgac agcctcagag     30360
     ctgaaatatt cctcctggcc ctgagaaaag tgggctaaag ttctcccttc tgcgtgtgtt     30420
     acccagtggt ttgcccccct ttcatcacct gtgaccaaca tgggctcatt ggggatattt     30480
     gtgctgtcat ttctggcaca agaacccaaa gatctaagac cataaaatgc atttggtctt     30540
     tcatactgtc tattcccatc agggcagaca tctatccatt aatacatttt atttaatttt     30600
     cttgtcttat attttcagag caatgatgag taatgagtga ggtaaggggt acctttgcat     30660
     ttttttgatc tcagggaaaa tgtcctccat gcagtaagat gatgactccg gaccaagaca     30720
     ggtgtgtgtg tgtgtgtgtg tgtgtgcgcg cgcgcgcgcg tgcgcgtgca cacgtgcaca     30780
     cgcatgtgtg ttaccatatc ataaacaaat ttatctgttt ctgtattctt acgtgatttt     30840
     tattagggat agatattaaa atttgccaaa cacattaaaa atctattgat acaatatgat     30900
     ctttggttgt gatgtaataa tatggtatta taccaaaact tttattaatg ttgaacccaa     30960
     ccattatttt aagtataaat cccacttgac aatggtgtat aaatgcgtaa atctggtgtt     31020
     gaaatcagtt cgttcctcaa atttcctggt tcaagtgatc ctcccacctc agctccttga     31080
     gtagccggga ttccaagtgg gtgtcaccat gcctggctaa ttaaaaacaa atcttatttg     31140
     tctcaacata ttgcccagtc tggtctcgaa ctcctgggca caagcgatcc tcctgcctca     31200
     gcctcccaga atgagttaac attttatttt aaaattttgc attaatatgt ttattttatt     31260
     ttttattttt aaaattttta acttttattt taaattcagg tggtacatgt gcaggtttgt     31320
     tacaagggta tattgtgtga tgttgaagta tacaatttta tctttttaaa ttgctcttaa     31380
     tacatatttt taatttaaat ttcaactttt attttaaata tagcaggtac acgcgcaggt     31440
     ttgttacatg ggtgtattgc acccgggttg tgagcattgt acccaacagg tagtttttta     31500
     caccattccc tcctctccct ccccctccta gcagtgccca gtgtctattg ttctcatgtt     31560
     tatgccatgc gtgctcaatg tttatctccc acttaaaaat gagaacacgt ggtatttggc     31620
     tttctgtccc tgtgttagtt gcctaggatt atgtccccct gctgcatcca tgttgcttca     31680
     aaggacatta ttttattcct ttttatggat gcatagtatt ccatggggta tataaactat     31740
     attttcttta tccaacccac cactgacggg cacctaggtt gatcccatgt ctttggtatt     31800
     gtgaatagtg tggtggtgaa tatacaagtg catgtggcct ttgggtataa tgatctattt     31860
     gtctttggat agataccctg taatgggatt gctgggtcaa atggtagctc tgttttaagt     31920
     tctttgagaa gtcttcaaac tgctttccac aatgcctgaa atacggtgta tacgtgtttt     31980
     ctttactcta cagcctcacc atcagctgtt gtttttttac tctaattata gccattctga     32040
     ctggtgtgac atggcgtctc attgtggttt tgatttgcat atcttgatga ttagtgatga     32100
     tgagcatttc tccacagttt tgttggccac taatatagtg cagttttaag ttcatagcaa     32160
     aatacagaag aaggtagaaa gatattccct atcctccctg gctccacaca tgtccagcct     32220
     tcccccttat caacgggtcc catcagaaat gtacatgtcc tgtaattgat gaaccacatt     32280
     gacaggtcat tatcactaca agtcagtatt ttccttaagg aatttttctc gctgatgcac     32340
     atcctatggc tatgggtttg tgcaaatata taatgacata tatccaccat tacagtatca     32400
     tgcagtgtat ttcccttccc tacaaatctt ctggctttac tgattcatct ctctctctcc     32460
     cctaaccttt ggaagtcgat gacttttcta cttttttcct ttgtttgact gtaatacact     32520
     tgaaattatt tccccctttt tggactgtaa tatacttgga atcacgtatc atgtcatttg     32580
     caggtcagct ccttttactt actaataagc atttaagttt cttccatgtc ttttcgtggt     32640
     ttgatagtgt gttgtccata aacatgtaga atatattaat ataaagtact ttggagctga     32700
     tcacatcact ggccattcag gtttttcaat tactgtttgt tgaatgacag tgaccagtca     32760
     gatgacagga agtcttagac cccctgagaa cacagaagat ggactgagga tgtcagggtc     32820
     accgaggact gcactgggtg ctctcatgga gggctcagta ggggtgtcct ctagttccag     32880
     tgagcctgga ctgtgatggg cactcagaga agggtcctct ctagcctagc agagcccctg     32940
     ctcacaggcc taccagctgt cccagcagct ttccctccca ggtccttccg tggggcagac     33000
     agagtctcac tgcctgttag cccttcctac ccacaagacc ctcagcaaaa gatccttatt     33060
     cagtgctcag ggagaggtgg ggcagatagc agctggggcc acacctgcat gaccagctcc     33120
     tcctcgctga ggcctacagc aggtaataaa ctcaatccat cccactggac caaagggagc     33180
     tgtgtctacc atggcctgga cccctctcgt gcttgtcctc actccctgca catgtaggga     33240
     aaaggcctag agacctgggg cagttcccag cttgtgtcag cccctctggc tcagacttgc     33300
     caacagctta accctgacac ctgctccaac aatgtaaatg tttgcatttc caggttccct     33360
     cttccaggct gggctgaccc aggtgtcctc actcccagca tcttcatgca gatcaaacac     33420
     tcacctgcac tcagagcata tcggctttca tatcggtggc aaaaatacct tcttttccct     33480
     acagaatcca gggagccctc caactatgtt ctgagattat gctcaggcta aaatgagtac     33540
     caggcctctg gggtccccag acaattctct gggttgagag gctcctccag agtctcaagt     33600
     tatttggtcg tctctggcct tcaccttgag gatggagcag atcatctctc tcagatgggc     33660
     tgacagggca tggcttacac tgtgctctag gccaatggga aaatcccctc tgcttgtgct     33720
     gcctgggctc ccactaggcc cctgctgttt gtgacaacag ccagcactgg tggtgacgct     33780
     tcagccatgt atgccctacg gtgagagtct gcagcccttc cacgcaacta tcacttgcag     33840
     aatgtctgca tcattgctaa tagcacattc tgagcctcct cacgtttctg tgggcaacaa     33900
     tttccttccc aagacgtgca catgatacag gagatttatt taccaaataa gtttattagg     33960
     aatccaatta taattagaag atattcatca gtgatcgggg gaaatacctg gtataattaa     34020
     aatagaattt gatgaaaata taaataaaga actaaattat gaaggtgtgg gcagagagtc     34080
     tggacaccct aagggagatg gaaaaccatt catccttgcc aggaatgaat gtctctggga     34140
     tgcttctcta acaggaggaa cctggagtga gaccaggaac ctggagaact agcagctggg     34200
     tgactggaaa ggaaaccatc tggggtgggg ttgggtctgc aaggcaggag gtgtctgggc     34260
     agagaaagca gggctggggc ggagggtcct gcctcatccc attctcctgc tcactccttc     34320
     ctagatccct gtcagggcag taaccatgag caaggcttga ggctacttct tataaactgt     34380
     ggccctgggc acattcctta gctcacctga gcctcagttt cttgatgaga aaaaatcggg     34440
     acaatagcaa ccaacctatc tcagagggct gctgtgagac cctgagccac tgtttctcaa     34500
     actgcccctg agatcaccta caacagaatg gctgtagggt gaagtttgag aaccgcagta     34560
     taggtgaggt ggtgcgtggg gcaggccctc ccacactgta aagtgcagtg tggtgcggta     34620
     aaagctgata ttcccgcagg catcctcaga gtgggcccaa ttagactctt gagcactgat     34680
     tccattcaag gtctgcggct tagagaggat ggcaaagtga ggcaccacca ggagcttgtc     34740
     cctatgggct ccaggccaag gacgtgcctg gagatgactc ctgccttgtg gcgctgtcac     34800
     tgcctcactg tccacattcc atcacgcctc agatcctggc ttccaccctg gtgaaaggaa     34860
     tctttcaata tcacccaccc agccacagac gcttctctgc ttctctggca aggctgcacc     34920
     ccctggctag gtgggcaggg ccaggggctc cttgagacag tctgcagcca ctgagctctc     34980
     cagcctccag ggcagaggta cagtcccatg gagcgtggct gatctgaagg cagttctggc     35040
     ctaaaagggg tcttgtccct tcctcgtcct cattgctccc aaggccaggt tggcagcagt     35100
     agcagcgggg ttggatgcta ttggatggga gaaggtgaat ggactcggag tgcagaatca     35160
     agctgcggaa gccaagggcc ttgaaggagg gtcacacaca agggacaact gcagaggaaa     35220
     ataaaggaac actttgtgat tagccctgcc tgtggctgaa agcgcagtgc agaagcatag     35280
     taaggaagga ctgggtggtc tgggtttaag acctaggaac cgtctctgct cctccaagcc     35340
     tgaatgagcc ctataaccta agggtcctgg aggtcttgaa accttctgcg gagaaggctc     35400
     caggtccact gggccctgtg ggtggaagag cagagtcaca gccccgcact ggggacctaa     35460
     caggtgtggc cttgctaggg ccccagaatg ggaccagagt gggtgggagg gggcagaagc     35520
     tctgagagca ccccctcctt cctgaagcct gtgcttctga gacacatccc aggaccctct     35580
     atgtggttcc ccatgtctct gtattttcat tcagcttcga gtagctctcc aaactgtgtt     35640
     ccagggaacc cccgtgttaa cctgtgaggg cctccaggaa gggggtccag gtggggtatg     35700
     cttggtgggc tctgggtttc cttacaggag ctctcatata agtcctggtg cagcctggga     35760
     atctactact gagttggggc gggggcgggt ctgagtccga aacattcctg acctgcccct     35820
     caaagaaagg tcccactgaa cagtctggaa agctgttttg ctgagctccc gtcatcactc     35880
     aatgaggcac gggcggagtg tggagggagt ttccaacaca cagtggatcc cgcacaggtg     35940
     tctctcctcg ggtggctggg gaggggagca caagaaggca ctgaggtcag agggcagctg     36000
     ccaccagcac ctggcaccac agggcagtct ggcctacagg gtattttcta aacctggcat     36060
     gtgaatgggt tccatggggc acccagctgc ctctaagacc ataaggcctt gttgtgagaa     36120
     tgggaattgc agcaggtcct gggaagctgc cagacgcaca cgggcaccat gtacagggct     36180
     tctcagagat gggagcaggg agcaggggac ggagaagcgt ggggtcaaga gcgtggccct     36240
     gagcaggggg ctgcagcgaa gaccaagggg attcataagc cagatccagg gagggggtct     36300
     cccagcccca cctgctccac taaactcctc tcctgccgga gccacagctg tcaaggccgc     36360
     cttccttaag gcatcagggc cactgcttgt gcacacagct accatcagca gcacggattg     36420
     agatggggtg tgagtgcaaa ctgggtctat tccccagggc ttcagggttg gggcatccct     36480
     gcccgtactg ccagggtgta gggatagcag ggagcactct gggcacgtgt atgcaggctg     36540
     aagggagacg tattgggttt cggagaggga aagagggccc cacaggtgcc cagggacacg     36600
     gtaacgctct gacatcgctg caccagcaaa ggggccccag ctctggataa gataaaatgc     36660
     attttaatag tttgaagtgc catgaggtgt ctgcatggca ctgcagcctg ggtgagggag     36720
     gacagggtca tcatacaaag taggcggcca gggctgacat cttgtccttg ggccgtctgg     36780
     ggttgggctt cccagggggc ctcctggccc ggccccgccc tcgaccctgc cttctccctg     36840
     gtccaccgcg gtgcatgggg tggcaggagg ccgcatgctt cagctccacc agctcctgga     36900
     agacggggtc acaaaagacg cagcccatgt gctgcgcctc atcgcccggg agtggggact     36960
     tggccttgtt gaagtccaca tcaagcaagg cggcctcaca gacactgcag gtgtcggcgg     37020
     acacccgcac gcggtgggcg ttctcgaagc agtgcgctac cacgttgcac ttgttgcagg     37080
     ccaccttcca cttggggccc gaggtggggt ccagcaccag caccccgctc tcacattcca     37140
     cgcactggcc gatgcccagc atgctcagcg agtgctggca ggaggggtgc gtacactcgt     37200
     tgcagcccat gcctggcggg agaagggagc cctgtaaagg cacgcccact gtgcccacct     37260
     gccctctgct gcctgctccc aatgcctcaa gctcctggat ccctcgtccc agcagaagga     37320
     actcttcttg gccttgctct tggggacagc cttgctcatg tttcggctcc tggctgccat     37380
     tacccctgtt ttctgcttac ctgaaacctc ctcaactttc aaggcccctc gctggcgcca     37440
     tcccagtggg tttcagctga ctccatcccc cctttgcttt gctgccagct tgttactggt     37500
     aatgccacat gaccctcatg tcactgggcc acatgggacc accctgtcag ctactctggc     37560
     ggcagcagga gggcagggat ggggtctcac tcccggggca gcctgggtgc agactgaggc     37620
     ctgagggggc tttctgcaga gcacacggtg aatgtgggca gatgcctcac tcccgctgat     37680
     tcctggtctg gctcggtgct ctgtcctgcc tgcctggaca tgcgctccct cctccagtaa     37740
     tgaggacgag gatgaggatg gaggacagtg gtggacgctg actgggggtg cccgctcacc     37800
     gggtgggtcc cccgactgct gcatcctctt gctgactcag ctccagaggg agcactgcac     37860
     acctgcgccc aggtcctgag ggtggactag ggttgcctgc tcgattctga cacagagaga     37920
     gggtggcacc actggctgag gcctaagcag tgccccagct acatccaggg tctctcgtct     37980
     cagtgccaat gagtgcagga aaggccaggg tgaggggtcc cctcagagtc cagcctggtg     38040
     caaggcaggg gttggcactg aacagagact gcagctacct gtggacagga gggagcggct     38100
     gcactcacct tgatgctgct gttcaacaat ggattgctgt tgcgcctaac caactttaag     38160
     acttggtggg cttgacacaa cttaccttgt gataggcaga tgtgaatgtg tggtcaacag     38220
     gtatcttatg gtcctccgct agggccaaca gcactgcaga agttgtttta caaaacacat     38280
     gcaattcatt actgcagact gcacttagcc ctgctaagtg cagggctgga gggcctgtgc     38340
     tgtgattctc ccactggagc tcactgcaaa ttccacatgg catcttttct taccaccgac     38400
     ccctccagtc ccctaaattc tgccgagtct tatggcccaa gcagcagggc tgttttcact     38460
     gcagccttgt caggcagcag atgacttttc tacgccaggc tgcattcaaa ggtggcagcc     38520
     ttctgtagac caacgacata ggccagaagt ggaacatgct gttcccaaaa cctgaagagt     38580
     tctgccaggc attatgtttg gacgatctga cccatcctgc cttgaccact taggcactca     38640
     aaactgtact cacgtgacag ttccctgaat cttcatacag attatctcct accctttata     38700
     gtgcatgttt cttatgaagg cctccaacat gctagccatt tcctactaaa ctaactcaac     38760
     tagcatgatg tcaacaacac agtcaatcaa tgggatattt tgtggggtgc tcagatggca     38820
     gaatgctccc acatcaataa aactcaccct tatctaatct tcatgttctg gtccccctct     38880
     atcacccacc ctcatgatcc agtcccatgc ctagtccctt gactcctgct ggtacctgct     38940
     ggttaggtct tatggctcct ctggtgtgta gtcccttttc ttcccctttt aaaaaatgtt     39000
     ttgagacagg gtcttttctg tcccctagac tggagtgcag tgtcatgatc atggctcact     39060
     gcagctttga cctcctgggg tcaagtgatc                                      39090