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Database contains
251540 sequences
from 368 species

IMGT/LIGM-DB sequence

Version:
1.2.11
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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MH359407 - Annotation

Sections
Accession number MH359407
Sequence version 1
Secondary accession numbers
IMGT annotation level by annotators
Definition Homo sapiens immunoglobulin heavy chain variable region (IGHV1) gene, IGHV1*69new allele, partial cds.
Species Homo sapiens (human)
Taxonomy cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens
Sequence length 545
IMGT/LIGM-DB dates 24-JUL-2018
  16-JUN-2024 (v. 8)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type gDNA
Configuration type germline
Gene type variable
Molecule entity type V-gene
Functionality type functional
Chain type IG-Heavy
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), immunoglobulin (IG), IMGT reference sequence

CLASSIFICATION

IMGT Groups IGHV
IMGT Subgroups IGHV1

DESCRIPTION

V-GENE   1..>545
  allele IGHV1*69new
  db_xref taxon:9606
  functional
  gene IGHV1
  IMGT_allele IGHV1-69*17
  IMGT_gene IGHV1-69
  mol_type genomic DNA
  organism Homo sapiens
  protein_id AXE72745.1
5'UTR   1..92
L-INTRON-L   93..235
L-PART1   93..138
atggactggacctggaggttcctctttgtggtggcagcagctacag M D W T W R F L F V V A A A T
W T G P G G S S L W W Q Q L Q
G L D L E V P L C G G S S Y
INIT-CODON   93..95
DONOR-SPLICE   138..140
V-INTRON   139..224
ACCEPTOR-SPLICE   222..226
V-EXON   225..531
gtgtccagtcccaggtgcagctggtgcagtctggggctgaggtgaagaagcctgggtcctcggtgaaggtctcctgcaaggcttctggaggcaccttcagcagctatgctatcagctgggtgcgacaggcccctggacaagggcttgagtggatgggagggatcatccctatctttggtatagcaaactacgcacagaagttccagggcagagtcacgattaccgcggacaaatccacgagcacagcctacatggagctgagcagcctgagatctgaggacacggccgtgtattactgtgcgagaga V S S P R C S W C S L G L R * R S L G P R * R S P A R L L E A P S A A M L S A G C D R P L D K G L S G W E G S S L S L V * Q T T H R S S R A E S R L P R T N P R A Q P T W S * A A * D L R T R P C I T V R E
C P V P G A A G A V W G * G E E A W V L G E G L L Q G F W R H L Q Q L C Y Q L G A T G P W T R A * V D G R D H P Y L W Y S K L R T E V P G Q S H D Y R G Q I H E H S L H G A E Q P E I * G H G R V L L C E R
V Q S Q V Q L V Q S G A E V K K P G S S V K V S C K A S G G T F S S Y A I S W V R Q A P G Q G L E W M G G I I P I F G I A N Y A Q K F Q G R V T I T A D K S T S T A Y M E L S S L R S E D T A V Y Y C A R
L-PART2   225..235
gtgtccagtcc V S S
C P V
V Q S
V-REGION   236..531
  CDR_length [8.8.2]
  FR_length [25.17.38.G]
  functional
  IMGT_allele IGHV1-69*17
  IMGT_gene IGHV1-69
caggtgcagctggtgcagtctggggctgaggtgaagaagcctgggtcctcggtgaaggtctcctgcaaggcttctggaggcaccttcagcagctatgctatcagctgggtgcgacaggcccctggacaagggcttgagtggatgggagggatcatccctatctttggtatagcaaactacgcacagaagttccagggcagagtcacgattaccgcggacaaatccacgagcacagcctacatggagctgagcagcctgagatctgaggacacggccgtgtattactgtgcgagaga Q V Q L V Q S G A E V K K P G S S V K V S C K A S G G T F S S Y A I S W V R Q A P G Q G L E W M G G I I P I F G I A N Y A Q K F Q G R V T I T A D K S T S T A Y M E L S S L R S E D T A V Y Y C A R
R C S W C S L G L R * R S L G P R * R S P A R L L E A P S A A M L S A G C D R P L D K G L S G W E G S S L S L V * Q T T H R S S R A E S R L P R T N P R A Q P T W S * A A * D L R T R P C I T V R E
G A A G A V W G * G E E A W V L G E G L L Q G F W R H L Q Q L C Y Q L G A T G P W T R A * V D G R D H P Y L W Y S K L R T E V P G Q S H D Y R G Q I H E H S L H G A E Q P E I * G H G R V L L C E R
FR1-IMGT   236..310
  AA_IMGT AA 1 to 26, AA 10 is missing
caggtgcagctggtgcagtctggggctgaggtgaagaagcctgggtcctcggtgaaggtctcctgcaaggcttct Q V Q L V Q S G A E V K K P G S S V K V S C K A S
R C S W C S L G L R * R S L G P R * R S P A R L
G A A G A V W G * G E E A W V L G E G L L Q G F
1st-CYS   299..301
CDR1-IMGT   311..334
  AA_IMGT AA 27 to 38, AA 31, 32, 33 and 34 are missing
ggaggcaccttcagcagctatgct G G T F S S Y A
E A P S A A M
R H L Q Q L C
FR2-IMGT   335..385
  AA_IMGT AA 39 to 55
atcagctgggtgcgacaggcccctggacaagggcttgagtggatgggaggg I S W V R Q A P G Q G L E W M G G
S A G C D R P L D K G L S G W E
Q L G A T G P W T R A * V D G R
CONSERVED-TRP   341..343
CDR2-IMGT   386..409
  AA_IMGT AA 56 to 65, AA 60 and 61 are missing
atcatccctatctttggtatagca I I P I F G I A
S S L S L V *
H P Y L W Y S
FR3-IMGT   410..523
  AA_IMGT AA 66 to 104, AA 73 is missing
aactacgcacagaagttccagggcagagtcacgattaccgcggacaaatccacgagcacagcctacatggagctgagcagcctgagatctgaggacacggccgtgtattactgt N Y A Q K F Q G R V T I T A D K S T S T A Y M E L S S L R S E D T A V Y Y C
T T H R S S R A E S R L P R T N P R A Q P T W S * A A * D L R T R P C I T
L R T E V P G Q S H D Y R G Q I H E H S L H G A E Q P E I * G H G R V L L
3'V-REGION   521..531
tgtgcgagaga C A R
V R E
C E R
2nd-CYS   521..523
CDR3-IMGT   524..531
  AA_IMGT AA 105 to 106
gcgagaga A R
R E
E R
V-RS   532..>545
3'UTR   532..>545
V-HEPTAMER   532..538
V-SPACER   539..>545

Literature references

[1] 1-545
Gadala-Maria,D., Yaari,G., Uduman,M., Kleinstein,S.H.
"Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles"
Proc. Natl. Acad. Sci. U.S.A. 112(8):E862-E870 (2015)
PUBMED: 25675496
[2] 1-545
Vander Heiden,J.A., Stathopoulos,P., Zhou,J.Q., Chen,L., Gilbert,T.J., Bolen,C.R., Barohn,R.J., Dimachkie,M.M., Ciafaloni,E., Broering,T.J., Vigneault,F., Nowak,R.J., Kleinstein,S.H., O'Connor,K.C.
"Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing"
J. Immunol. 198(4):1460-1473 (2017)
PUBMED: 28087666
[3] 1-545
Kos J.T., Watson C.T., Kleinstein S.H., O'Connor K., Vander Heiden J., Gadala-Maria D., Marquez S., Nowak R.J., Ciafaloni E.

Submitted to the ENA/GenBank/DDBJ databases (15-MAY-2018)
Biochemistry and Molecular Genetics, University of Louisville, 580 S Preston St, Louisville, KY 40202, USA

Database cross-references

Database Identifiers Relation
EuropePMC PMC6381938, 30814994
IMGT/LIGM-DB MH359407
MD5 c6eb8f44beb91bf968492e7f2dde7529

Sequence

Length : 545 BP
Composition : 133 A; 134 C; 159 G; 119 T; 0 other

     gagataaata tagatatatt ggtgccctga gagcatcaca taacaaccac attcctcctc        60
     tgaagaagcc cctgggagca cagctcatca ccatggactg gacctggagg ttcctctttg       120
     tggtggcagc agctacaggt aaggggcttc ctagtcctaa ggctgaggaa gggatcctgg       180
     tttagttaaa gaggatttta ttcacccctg tgtcctctcc acaggtgtcc agtcccaggt       240
     gcagctggtg cagtctgggg ctgaggtgaa gaagcctggg tcctcggtga aggtctcctg       300
     caaggcttct ggaggcacct tcagcagcta tgctatcagc tgggtgcgac aggcccctgg       360
     acaagggctt gagtggatgg gagggatcat ccctatcttt ggtatagcaa actacgcaca       420
     gaagttccag ggcagagtca cgattaccgc ggacaaatcc acgagcacag cctacatgga       480
     gctgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgagag acacagtgtg       540
     aaaac                                                                   545