Version 1
: Received: 21 July 2021 / Approved: 26 July 2021 / Online: 26 July 2021 (15:30:30 CEST)
How to cite:
Folorunsho Ayodele, P.; Ibukun Akinloye, D.; Jaimiu Akamo, A.; Adejare Agboola, D.; Adeboye Akinloye, O. Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats. Preprints2021, 2021070589. https://doi.org/10.20944/preprints202107.0589.v1
Folorunsho Ayodele, P.; Ibukun Akinloye, D.; Jaimiu Akamo, A.; Adejare Agboola, D.; Adeboye Akinloye, O. Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats. Preprints 2021, 2021070589. https://doi.org/10.20944/preprints202107.0589.v1
Folorunsho Ayodele, P.; Ibukun Akinloye, D.; Jaimiu Akamo, A.; Adejare Agboola, D.; Adeboye Akinloye, O. Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats. Preprints2021, 2021070589. https://doi.org/10.20944/preprints202107.0589.v1
APA Style
Folorunsho Ayodele, P., Ibukun Akinloye, D., Jaimiu Akamo, A., Adejare Agboola, D., & Adeboye Akinloye, O. (2021). <strong></strong>Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats. Preprints. https://doi.org/10.20944/preprints202107.0589.v1
Chicago/Turabian Style
Folorunsho Ayodele, P., David Adejare Agboola and Oluseyi Adeboye Akinloye. 2021 "<strong></strong>Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats" Preprints. https://doi.org/10.20944/preprints202107.0589.v1
Abstract
The wide use of cadmium (Cd) in industry causes great environmental health problems to humans and animals. The aim of this study was to investigate the protective effects of Xylopia aethiopica fruit ethanol extract (XAFEE) on cadmium-induced inflammation and dyslipidemia in male albino rats. Thirty albino rats weighing 120–180 g were randomly selected into six groups (n = 5): control rats (administered distilled water only), Cd alone group (10 mg/ kg bw), Cd + 150 mg/kgbw XAFEE, Cd + 300 mg/kgbw XAFEE, 150 mg/kgbw XAFEE and 300 mg /kgbw XAFEE groups after 2-week acclimatization. The experiment lasted for 21 days, after which blood sample was collected by cardiac puncture. Changes in tumor necrosis factor (TNF-α), interleukin 10 (IL-10), total cholesterol (TC), triacylglycerol (TAG), phospholipids and free fatty acids (FFAs) concentrations in serum were determined. The results of the present study indicated that Cd exposure remarkably increased (p < 0.05) the TC, TAG, phospholipids, FFAs and TNF-α concentrations, and significantly decreased IL-10 concentration (p < 0.05). These findings suggest that inflammatory changes and alterations in lipid metabolism might be one of the mechanisms underlying the subtle effects of Cd toxicity, “dyslipidemia.” XAFEE expressed protective role against toxic influence of Cd on affected parameters in rats. The results raised the possibility of Xylopia aethiopica fruit being considered as a condiment in soup, local drinks, supplements or herbs preparations in areas where there are chances of Cd exposure, occupationally or environmentally.
Keywords
Medicinal plant; spices; condiment; anti-dyslipidemic effect; Cd toxicity
Subject
Biology and Life Sciences, Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.