Sakaguchi, C.A.; Nieman, D.C.; Omar, A.M.; Strauch, R.C.; Williams, J.C.; Lila, M.A.; Zhang, Q. Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise. Nutrients2024, 16, 36.
Sakaguchi, C.A.; Nieman, D.C.; Omar, A.M.; Strauch, R.C.; Williams, J.C.; Lila, M.A.; Zhang, Q. Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise. Nutrients 2024, 16, 36.
Sakaguchi, C.A.; Nieman, D.C.; Omar, A.M.; Strauch, R.C.; Williams, J.C.; Lila, M.A.; Zhang, Q. Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise. Nutrients2024, 16, 36.
Sakaguchi, C.A.; Nieman, D.C.; Omar, A.M.; Strauch, R.C.; Williams, J.C.; Lila, M.A.; Zhang, Q. Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise. Nutrients 2024, 16, 36.
Abstract
Mangoes have a unique nutrient profile (carotenoids, polyphenols, sugars, vitamins) that we hypothesized would mitigate post-exercise inflammation. This study examined the effects of mango ingestion in moderating exercise-induced inflammation in a randomized crossover trial with 22 cyclists. In random order with trials separated by a 2-week washout period, the cyclists ingested 330 g/day mangoes with 0.5 liters water or 0.5 liters water alone for 2 weeks, followed by a 2.25-h cycling bout challenge. Blood and urine samples were collected pre- and post-2 weeks supplementation, with additional blood samples collected immediately post-exercise, and then 1.5-h, 3-h, and 24-h post-exercise. Urine samples were analyzed for targeted mango-related metabolites. The blood samples were analyzed for 67 oxylipins that are upstream regulators of inflammation and other physiological processes. After 2-weeks mango ingestion, three targeted urine mango-related phenolic metabolites were significantly elevated compared to water alone (interaction effects, p≤0.003). Significant post-exercise increases were measured for 49 oxylipins, but various subgroup analyses showed no differences in the pattern of change between trials (all interaction effects, p>0.150). The 2.25-h cycling bouts induced significant inflammation but no countermeasure effect was found after 2-weeks mango ingestion despite the elevation of mango gut-derived phenolic metabolites.
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