Frontiers in Pharmacology

🌿🔍 Research Topic Alert! 🔍🌿 Our Research Topic "Repositioning Natural Products for Drug Discovery against Neglected and Infectious Diseases" remains OPEN for submissions. 📎 Register your participation: https://fro.ntiers.in/3dqC 🔎 Explore the topic: https://fro.ntiers.in/oqvW Neglected and infectious diseases remain a significant global health challenge, with millions affected worldwide. 📨 Please consider sharing with your network and submitting your research to make a meaningful impact on global health! #NaturalProducts #NeglectedDiseases #Research #HealthInnovation #FrontiersIn #Pharmacology #OpenAccess

Exciting News! 📢 Submissions are now OPEN for our groundbreaking collection on cancer therapy! 🧬 CRISPR/Cas9 and Cancer Drug Discovery: A New Road for Cancer Therapy 🌟 👤 Guest Editors: Dr. Mounir Tilaoui and Dr. Nelson Shu-Sang Yee 🔍 Learn more: https://fro.ntiers.in/FPYo ✍️ Register to participate: https://fro.ntiers.in/bTZh #CancerTherapy #CRISPR #DrugDiscovery #OpenScience

Thank you Alekhya Lavu for the invitation! Université de Montréal Centre de recherche Azrieli du CHU Sainte-Justine CAMCCO-L Grossesse en Santé CIHR Institute of Gender and Health | Institut de la Santé des Femmes et des Hommes des IRSC Fonds de recherche du Québec

🚀 Exciting breakthroughs in pharmacology! 🚀 We're back with more groundbreaking original research published in Frontiers in Pharmacology, shedding light on innovative treatment strategies that could transform medical practice. Check out these fascinating studies from July: 1. Advancing Drug Discovery through Assay Development: A Survey of Tool Compounds within the Human Solute Carrier Superfamily; by Daniela Digles et. al. https://lnkd.in/didEY8QU With over 450 genes, Solute Carrier Transporters (#SLCs) are vital for transporting nutrients, metabolites, and xenobiotics in human cells. This article addresses challenges in developing SLC-targeting drugs and systematically annotates highly selective tool compounds, advancing precise drug development. 2. Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells; by Vivien R. Sutton et. al. | Peter MacCallum Cancer Centre https://lnkd.in/dpjspyy6 DPP1 (cathepsin C) reduces suppurative inflammation by targeting neutrophil serine proteases (#NSPs). This study shows that DPP1 inhibition, even with high concentrations of brensocatib, does not impair the cytotoxic abilities of human CTLs, NK cells, or CAR T cells. These findings indicate that reversible DPP1 inhibitors like brensocatib can treat inflammation without compromising immune function. 3. Artificial intelligence integration in the drug lifecycle and in regulatory science: policy implications, challenges and opportunities; by Wahiba Oualikene-Gonin et. al. | ANSM Agence nationale de sécurité du médicament et des produits de santé https://lnkd.in/dUGUf8BS AI tools are revolutionizing drug development, but regulatory agencies face challenges in ensuring safety and reliability. Key issues include adapting regulations and evaluating AI data and models. This article examines the evolution of regulations and how AI can enhance medical agencies' internal processes. 4. The critical role of glutamine and fatty acids in the metabolic reprogramming of anoikis-resistant melanoma cells; by Silvia Peppicelli et. al. https://lnkd.in/dPkMuXys  Peppicelli et al. identified key metabolic vulnerabilities in anoikis-resistant melanoma circulating tumor cells (#CTCs). These cells switch from glycolysis to oxidative metabolism, using glutamine and fatty acids in suspension. Targeting these pathways with specific metabolic inhibitors (rotenone, BPTES, SSO, etomoxir) significantly reduces cell viability and colony formation, potentially leading to new therapies for melanoma metastases. #Pharmacology #DrugDevelopment #MedicalResearch #CancerResearch #ArtificialIntelligence #HealthcareInnovation

📣 Submissions are OPEN for this exciting collection! 🔬 This Research Topic provides a comprehensive exploration into the practice and implications of the 4R principals in ethnopharmacology: Reduce, Refine, Replace and Responsibility. 🔎 Find out more about here: https://lnkd.in/dERfKiWK ✔ Submit your manuscript here: https://lnkd.in/d9HCTyA9

🌟 Exciting News from the Ethnopharmacology Section! 🌟 Our Specialty Chief Editor of the Ethnopharmacology section, Prof. Michael Heinrich, is attending the International Congress on Natural Products Research (ICNPR) in Krakow today! Prof. Heinrich's pioneering work and dedication to the field have been instrumental in advancing our understanding through many years of research in medicinal and food plants. 🗓 If you're interested in meeting the journal team, we invite you to join us at ICNPR in Krakow. Learn more here: https://www.icnpr2024.org/ Prof. Heinrich and the Frontiers in Pharmacology team will be available until Wednesday, July 17, 2024, to discuss the latest developments in ethnopharmacology and network with fellow researchers and enthusiasts. Don't miss this opportunity to connect with experts in the field and gain insights into cutting-edge research! #Ethnopharmacology #ICNPR2024 #NaturalProductsResearch

🚀 Exciting breakthroughs in pharmacology! 🚀 We are thrilled to share some groundbreaking original research published in Frontiers in Pharmacology in June, that could revolutionize treatment strategies across various medical fields: 1. The potential neuroprotective effects of cannabinoids against paclitaxel-induced peripheral neuropathy: in vitro study on neurite outgrowth; by Ioana Creanga-Murariu et al. https://lnkd.in/dChVvCXB Chemotherapy-induced peripheral neuropathy (CIPN) affects 68.1% of patients on Paclitaxel, causing severe pain and sensory loss. Current treatments are often ineffective, and no preventive medications are recommended. This exciting new research explores the use of cannabinoids, known for their neuroprotective properties in other neuropathies, as a potential solution for CIPN. 2. Influence of β-lactam pharmacodynamics on the systems microbiology of gram-positive and gram-negative polymicrobial communities; by Nicholas Smith et al. https://lnkd.in/dDNxkpgn In this article, Smith et al. evaluated the effectiveness of β-lactam antibiotics against mixed bacterial communities of harmful gram-positive and gram-negative pathogens. This study spotlights the protective role β-lactamase-producing E. coli play in bacterial communities, reducing the efficacy of common β-lactam antibiotics. Understanding these interactions is crucial for improving infection control strategies. 3. CaMKIIδ-dependent dysregulation of atrial Na+ homeostasis promotes pro-arrhythmic activity in an obstructive sleep apnea mouse model; by Philipp Hegner et al. https://lnkd.in/d3E9m4At New research reveals significant insights into how obstructive sleep apnea (OSA) contributes to arrhythmias like atrial fibrillation through increased reactive oxygen species (ROS) and sodium dysregulation. This study underscores the direct impact of OSA on heart cell electrochemistry and arrhythmia risk, suggesting new therapeutic avenues focusing on the CaMKIIδ pathway for OSA-related arrhythmias. 4. Toward high-resolution modeling of small molecule–ion channel interactions; by Brandon Harris et al. https://lnkd.in/dHUNJN3s Ion channels are crucial drug targets for conditions like epilepsy, pain, and cardiac arrhythmias. To create potent and selective drugs, scientists are turning to structure-guided design. This recent evaluation of two RosettaLigand docking methods (RosettaLigand and GALigandDock) showed they can frequently predict ligand-binding poses with good accuracy. Dive into these articles to explore how these innovative research efforts are pushing the boundaries of pharmacological science! 🧬 #Pharmacology #MedicalResearch #Neuroprotection #Antibiotics #Cardiology #DrugDevelopment #HealthcareInnovation

🌍 On this UN International Day Against Drug Abuse, we proudly spotlight our collections on "Substance Use Disorder: Above and Beyond Addiction." 📊 According to a new report from the World Health Organization (WHO), over 3 million annual deaths are due to alcohol and drug use (see report here: https://lnkd.in/dnkWeBP9). 📚 Our impactful research series explores the intricate world of Substance Use Disorders (SUD), delving into the mechanisms and effects of alcohol and drugs on the brain and behavior. Take a look at our achievements so far: 📄 32 Articles Published 👁️ 47,380 Total Views 🔗Download the PDF e-book of the collection here: https://lnkd.in/d6AwMMce 🚀 Our journey continues with Volume II, which is open for submissions. Already featuring 9 insightful articles, this series, led by Dr. Dasiel Oscar BORROTO-ESCUELA, Dr. Jaya Kumar, Dr. Mohd Fadzli Mohamad Isa, and Dr. Adj. Prof. Dr. Prem Kumar Shanmugam, aims to uncover further the complexities of Substance Use Disorder (SUD). Contributing to this vital field can help us understand and mitigate the global impact of SUD. 🔗Discover more and access our collection here👇 https://lnkd.in/dXpYkxSE #UNDayAgainstDrugAbuse #SubstanceUseDisorder #Research #MentalHealth #AddictionRecovery 

🔬 New Research Topic Alert! 🌍 We are thrilled to announce our latest research topic, "Alternatives to Conventional Antibiotics: Biologics, Chemical Modulators, and Microbiome Manipulation," is now open for submissions! Are you ready to shape the future of antimicrobial strategies and tackle the urgent challenge of antibiotic resistance? Join us! 📝 Submission Deadline: 26 November 2024 📚 Explore Our Research Topic: https://fro.ntiers.in/k2QZ ❓ Questions? Contact us at: [email protected] #Research #Biologics #Antibiotics #Microbiome #ChemicalModulators #Science #AcademicPublishing #OpenAccess #AntimicrobialResistance #AMR

📣 Submissions are still OPEN for this exciting article collection! ⚠ Antibiotic resistance is one of the biggest threats to global health, food security, and development today. 💊 This collection welcomes manuscripts from global researchers contributing to the collective effort in unearthing nature's potential to unveil the future of antibiotics and combat antibiotic resistance effectively. 👉 Read more about the collection here: https://lnkd.in/eC7ECC7M ✔ Submit your research before 1st October: https://lnkd.in/e73JRUPA #antibioticresistance #naturalproducts #worldhealthorganization #medicinalplants #researchtopic #openaccess