Motor Proteins
- 1Department of Pharmacology and Therapeutics and the Myology Institute, University of Florida, College of Medicine, Gainesville, Florida 32610-0267
- 2Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
- Correspondence: lsweeney{at}ufl.edu; holzbaur{at}mail.med.upenn.edu
SUMMARY
Myosin motors power movements on actin filaments, whereas dynein and kinesin motors power movements on microtubules. The mechanisms of these motor proteins differ, but, in all cases, ATP hydrolysis and subsequent release of the hydrolysis products drives a cycle of interactions with the track (either an actin filament or a microtubule), resulting in force generation and directed movement.
